A5075437630- Protease and Inhibitor Mechanisms
- Hormonal Regulation and Hypertension
- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Blood Pressure and Hypertension Studies
- Eicosanoids and Hypertension Pharmacology
- Renal and Vascular Pathologies
- Atherosclerosis and Cardiovascular Diseases
- Pregnancy and preeclampsia studies
- Aortic aneurysm repair treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Renal function and acid-base balance
- Cardiac Fibrosis and Remodeling
- Cardiovascular Health and Disease Prevention
- Sodium Intake and Health
- Birth, Development, and Health
- Phytochemicals and Antioxidant Activities
- Alcohol Consumption and Health Effects
- Biochemical Analysis and Sensing Techniques
- Venous Thromboembolism Diagnosis and Management
- Stress Responses and Cortisol
- Acute Kidney Injury Research
- Pulmonary Hypertension Research and Treatments
- Peptidase Inhibition and Analysis
- Cardiac electrophysiology and arrhythmias
Universidade Federal de Ouro Preto
2020-2025
Universidade Federal de Alfenas
2015-2022
Universidade de São Paulo
2009-2018
Universidade de Ribeirão Preto
2012-2018
University of California, San Francisco
2015-2017
San Francisco VA Medical Center
2017
Clinics Hospital of Ribeirão Preto
2011-2013
Universidade Federal de Santa Maria
2009
Mounting evidence indicates that structural and functional vascular changes associated with two-kidney, one-clip (2K-1C) hypertension result, at least in part, from altered activity of matrix metalloproteinases (MMPs). Because MMPs are upregulated by increased formation reactive oxygen species (ROS), we hypothesized antioxidant approaches could attenuate the increases MMP-2 expression/activity dysfunction remodeling 2K-1C hypertension. Sham-operated or hypertensive rats were treated tempol...
Increased oxidative stress and up-regulation of matrix metalloproteinases (MMPs) may cause structural functional vascular changes in renovascular hypertension. We examined whether treatment with spironolactone (SPRL), hydrochlorothiazide (HCTZ) or both drugs together modified hypertension-induced arterial blood pressure, aortic remodelling, reactivity, MMP levels activity, a model hypertension.We used the two-kidney,one-clip (2K1C) hypertension Wistar rats. Sham-operated hypertensive rats...
Vascular dysfunction associated with two-kidney, one-clip (2K-1C) hypertension may result from both altered matrix metalloproteinase (MMP) activity and higher concentrations of reactive oxygen species (ROS). Doxycycline is considering the most potent MMP inhibitor tetracyclines attenuates 2K-1C hypertension-induced high blood pressure chronic vascular remodeling. might also act as a ROS scavenger this contribute to amelioration some cardiovascular diseases increased ROS. We hypothesized that...
Nebivolol and metoprolol are β1-adrenergic receptor blockers with different properties. We hypothesized that nebivolol, but not metoprolol, could attenuate prooxidant profibrotic mechanisms of hypertension therefore protect against the vascular remodeling associated hypertension. Hypertension was induced in male Wistar rats by clipping left renal artery. Six weeks after surgery, hypertensive sham were treated nebivolol (10 mg kg−1 day−1) or (20 for 4 weeks. Systolic blood pressure monitored...
Hypertension induces vascular alterations that are associated with up-regulation of matrix metalloproteinases (MMPs). While these may be blunted by doxycycline, a non-selective MMPs inhibitor, no previous study has examined the effects different doses doxycycline on alterations. This is important because been used at sub-antimicrobial doses, and use lower prevent emergence antibiotic-resistant microorganisms. We studied 3, 10 30 mg/kg per day found in rat two kidney-one clip (2K1C)...
Inconsistent matrix metalloproteinases (MMPs) levels have been reported in hypertension, with higher, similar and lower MMPs hypertensives compared normotensives. Differences between studies may reflect lack of control drug effects, accompanying diseases pre-analytical issues. We MMP-2, MMP-8 MMP-9 38 untreated hypertensive patients (with no other diseases) those found 33 normotensive controls. also studied endogenous inhibitors (TIMP-1, TIMP-2 alpha-2-macroglobulin-A2M). Additionally, we...
Investigate the role of NADPH oxidase on ethanol-induced hypertension and vascular oxidative stress.Male Wistar rats were treated with ethanol (20% v/v).Apocynin (10 mg/kg/day, i.p.) prevented hypertension. The increased contractility endothelium-intact endothelium-denuded aortic rings from ethanol-treated to phenylephrine was by apocynin. Ethanol consumption superoxide anion (O2 (-)) generation lipid peroxidation apocynin these responses. decrease plasma nitrate/nitrite (NOx) levels induced...
Background and Objectives: The Antimicrobial Stewardship Program has shown satisfactory results in fighting antimicrobial resistance. Despite this, the program does not seem to be consolidated Brazilian hospitals, which requires an understanding of factors interfering its consolidation according pharmacists' perspective. No validated tool was found literature meet this objective. objective study develop test a for assessing obstacles implementation hospitals from perspective pharmacists....
Mounting evidence implicates matrix metalloproteinase (MMP) in the vascular dysfunction and remodelling associated with hypertension. We tested hypothesis that treatment pyrrolidine dithiocarbamate (PDTC), which interferes NF-κB-induced MMPs gene transcription, could exert antihypertensive effects, prevent MMP-2 MMP-9 up-regulation, protect against functional alterations of two-kidney, one clip (2K1C) hypertension.Sham-operated or hypertensive rats were treated vehicle PDTC (100 mg·Kg(-1)...
Nitric oxide (NO)-derived metabolites including the anion nitrite can recycle back to NO and thus complement formation independent of synthases. While is as a major vascular storage pool source NO, little known about drugs that increase tissue concentrations. This study examined effects atorvastatin or sildenafil, combination, on concentrations endothelial dysfunction in 2 kidney-1 clip (2K1C) hypertension model. Sham-operated 2K1C hypertensive rats were treated with vehicle, (50 mg/Kg),...
Hypertension induces left-ventricular hypertrophy (LVH) by mechanisms involving oxidative stress and unbalanced cardiac matrix metalloproteinase (MMP) activity. We hypothesized that β1-adrenergic receptor blockers with antioxidant properties (nebivolol) could reverse hypertension-induced LVH more effectively than conventional β1-blockers (metoprolol) when used at doses exert similar antihypertensive effects. Two-kidney one-clip (2K1C) hypertension was induced in male Wistar rats. Six weeks...
Imbalanced matrix metalloproteinase (MMP)-2 activity and transforming growth factor expression (TGF-β) are involved in vascular remodeling of hypertension. Atorvastatin sildenafil exert antioxidant pleiotropic effects that may result cardiovascular protection. We hypothesized atorvastatin alone or association antiproliferative by down-regulating MMP-2 TGF-β, thus reducing the hypertrophy induced two kidney, one clip (2K1C) Sham 2K1C rats were treated with oral 50 mg/kg, 45 both, daily for 8...