A5036953420- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Pain Management and Opioid Use
- Neuroscience of respiration and sleep
- Ginkgo biloba and Cashew Applications
- Health, Environment, Cognitive Aging
- Anesthesia and Pain Management
- Nitric Oxide and Endothelin Effects
- Anesthesia and Neurotoxicity Research
- COVID-19 Clinical Research Studies
- Breastfeeding Practices and Influences
- Stress Responses and Cortisol
- Retinoids in leukemia and cellular processes
- Sleep and Wakefulness Research
- Pancreatic function and diabetes
- Forensic Toxicology and Drug Analysis
- Pharmacological Effects and Toxicity Studies
- Neuroendocrine regulation and behavior
- Gastroesophageal reflux and treatments
- Prenatal Substance Exposure Effects
- Mercury impact and mitigation studies
- Sulfur Compounds in Biology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Universidade Federal de Alfenas
2016-2025
The University of Texas Health Science Center at Houston
2024
Universidade de São Paulo
2011-2023
Oxidative stress has been associated with normal aging and Alzheimer's disease (AD). However, little is known about oxidative in mild cognitive impairment (MCI) patients who present a high risk for developing AD. The aim of this study was to i
Exposure to environmental tobacco smoke (ETS) in the early postnatal period has been associated with several diseases; however, little is known about brain effects of ETS exposure during this critical developmental or long-term consequences exposure. This study investigated on both reference and working memory, synaptic proteins BDNF from late infancy adulthood (P3-P73). BALB/c mice were exposed generated 3R4F research cigarettes (0.73 mg nicotine/cigarette) P3 P14. Spatial memory evaluated...
Smoking crack cocaine involves the inhalation of and its pyrolysis product, anhydroecgonine methyl ester (AEME). Although there is evidence that neurotoxic, neurotoxicity AEME has never been evaluated. seems to have cholinergic agonist properties in cardiovascular system; however, are no reports on effects central nervous system. The aim this study was investigate possible rat primary hippocampal cell cultures were exposed different concentrations AEME, cocaine, a cocaine–AEME combination....
Abstract Environmental tobacco smoke (ETS) leads to the death of 600,000 nonsmokers annually and is associated with disturbances in antioxidant enzyme capacity adult rodent brain. However, little known regarding influence ETS on brain development. The aim this study was determine levels malonaldehyde (MDA) 3-nitrotyrosine (3-NT), as well enzymatic activities glutathione peroxidase (GPx), reductase (GR), S-transferase (GST), superoxide dismutase (SOD), distinct structures. BALB/c mice were...
Anacardic acids from cashew nut shell liquid, a Brazilian natural substance, have antimicrobial and antioxidant activities modulate immune responses angiogenesis. As inflammatory lung diseases been correlated to environmental pollutants exposure no reports addressing the effects of dietary supplementation with anacardic on inflammation in vivo evidenced, we investigated model diesel exhaust particle- (DEP-) induced inflammation. BALB/c mice received an intranasal instillation 50 μ g DEP for...
Estudos epidemiológicos mostram uma relação entre o uso em longo prazo de inibidores bomba prótons e metabolismo ósseo, porém essa ainda não está estabelecida. O objetivo deste estudo foi analisar as propriedade mecânicas a densidade mineral óssea (DMO) ratos submetidos ao omeprazol prazo. Cinquenta Wistar, 200 240 g, foram divididos igualmente cinco grupos: OMP300 (ingestão na dose 300 μmoL/Kg/dia), OMP200 (200 OMP40 (40 OMP10 (10 μmoL/Kg/dia) Cont (grupo controle; ingestão do veículo...
Epidemiological studies have shown a relationship between long-term use of proton pump inhibitors and bone metabolism. However, this has not yet become established. The aim the present study was to analyze mechanical properties mineral density (BMD) rats that were subjected omeprazole use.Fifty Wistar weighing 200 240 g divided equally into five groups: OMP300 (omeprazole intake at dose 300 μmoL/kg/day); OMP200 (200 OMP40 (40 OMP10 (10 Cont (control group; dilution vehicle). solutions...
The smoke of crack cocaine contains and its pyrolysis product, anhydroecgonine methyl ester (AEME). AEME possesses greater neurotoxic potential than an additive effect when they are combined. Since atropine prevented AEME-induced neurotoxicity, it has been suggested that toxic effects may involve the muscarinic cholinergic receptors (mAChRs). Our aim is to understand interaction between mAChRs how can lead neuronal death. Using a rat primary hippocampal cell culture, was shown cause...
ABSTRACT In the present study, we investigated whether curcumin administration would interfere with main renal features of l ‐NAME‐induced hypertension model. For this purpose, conducted both in vitro and vivo experiments to evaluate indicators inflammation, oxidative stress, metalloproteinases (MMPs) expression/activity. Hypertension was induced by ‐NAME (70 mg/kg/day), Wistar rats from control hypertensive groups were treated (50 or 100 mg/kg/day; gavage) vehicle for 14 days. Blood kidneys...
Environmental tobacco smoke (ETS) exposure during brain development has been associated with several disorders, such as depression, anxiety, sudden infant death syndrome, and the predisposition to addiction. The endocannabinoid system plays an essential role in neuronal development. We investigated effects of early postnatal ETS on different regions. C57BL/6 J mice were exposed that was generated from 3R4F cigarettes day 3 (P3) P14. Receptors enzymes assessed infancy, adolescence, adulthood...
Exposure to environmental tobacco smoke (ETS) is associated with high morbidity and mortality, mainly in childhood. Our aim was evaluate the effects of postnatal ETS exposure brain 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG) uptake mice by positron emission tomography (PET) neuroimaging a longitudinal study. C57BL/6J were exposed that generated from 3R4F cigarettes day 3 (P3) P14. PET analyses performed male female during infancy (P15), adolescence (P35), adulthood (P65). We observed...
Although environmental tobacco smoke (ETS) is mainly associated to cardiorespiratory disease, clinical and preclinical studies have showed that ETS induces behavioral disorders deleterious effects in the brain. Our aim was investigate of during early postnatal period on locomotor activity anxiety presynaptic proteins brain-derived neurotrophic factor (BDNF) distinct brain regions. BALB/c mice were exposed generated from 3R4F reference research cigarettes third fourteenth days life....
Crack cocaine smokers inhale, alongside with cocaine, its pyrolysis product, anhydroecgonine methyl ester (AEME). We have previously described AEME neurotoxic effect and additive when co-incubated cocaine. Our aim was to evaluate, the of AEME, AEME-cocaine combination on glutathione peroxidase (GPx), reductase (GR) S-transferase (GST) activities after 3 6 h exposure, periods previous neuronal death. Lipid peroxidation evaluated through malonaldehyde (MDA) levels at 3, 6, 24 48 exposure. All...
AbstractThe association between death from Covid-19 and case management, especially in small medium-sized municipalities, is still uncertain. To analyze sociodemographic, clinical, pharmacological factors associated with patients Coronavirus Disease 2019 (COVID-19), a Brazilian referral public hospital. This cross-sectional study, data the hospital records of (≥ 18 years old) diagnosed COVID-19, March 2020 to 2021. The sample was classified according clinical outcome into two groups (death...