A5007804149- Multiple Sclerosis Research Studies
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Long-Term Effects of COVID-19
- Medical Imaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Adipose Tissue and Metabolism
- Functional Brain Connectivity Studies
- Mitochondrial Function and Pathology
- Cannabis and Cannabinoid Research
- Advanced Neuroimaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Peptidase Inhibition and Analysis
- Frailty in Older Adults
- Protease and Inhibitor Mechanisms
- Retinal Imaging and Analysis
- Cell Adhesion Molecules Research
- Bone and Joint Diseases
- Radiomics and Machine Learning in Medical Imaging
- Adipokines, Inflammation, and Metabolic Diseases
- Thermal Regulation in Medicine
- Neuroscience and Neuropharmacology Research
- Down syndrome and intellectual disability research
- Liver Disease Diagnosis and Treatment
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2017-2025
Universidade de São Paulo
2015-2024
Hospital Universitário da Universidade de São Paulo
2024
Sociedade Brasileira de Neurociências e Comportamento
2018-2021
Fundação Faculdade de Medicina
2018-2020
Nuclear Engineering Institute
2018
Medicina
2018
University Medical Center Groningen
2013-2017
University of Groningen
2013-2017
Universidade Positivo
2011
Magnetic hyperthermia (MHT) has been shown as a promising alternative therapy for glioblastoma (GBM) treatment. This study consists of three parts: The first part evaluates the heating potential aminosilane-coated superparamagnetic iron oxide nanoparticles (SPIONa). second and third parts comprise evaluation MHT multiple applications in GBM model, either vitro or vivo. obtained curves SPIONa (100 nm, +20 mV) their specific absorption rates (SAR) stablished best therapeutic conditions...
Evidence suggests that exercise can modulate neuroinflammation and neuronal damage. We evaluated if such effects of be detected with positron emission tomography (PET) in a rat model Parkinson’s disease (PD). Rats were unilaterally injected the striatum 6-hydroxydopamine (PD rats) or saline (controls) either remained sedentary (SED) forced to three times per week for 40 min (EX). Motor cognitive functions by open field, novel object recognition, cylinder tests. At baseline, day 10 30, glial...
We tested the hypothesis that exercise training would attenuate metabolic impairment in a model of severe cancer cachexia.
Local minimally-invasive EV delivery on a thermo-actuated PF-127 gel enhanced residence time in colo-cutaneous fistulas promoting therapeutic effect.
An early and persistent sign of Alzheimer's disease (AD) is glucose hypometabolism, which can be evaluated by positron emission tomography (PET) with 18F-2-fluoro-2-deoxy-D-glucose ([18F]FDG). Cannabidiol has demonstrated neuroprotective anti-inflammatory properties but not been PET imaging in an AD model. Intracerebroventricular (icv) injection streptozotocin (STZ) a validated model for hypometabolism observed AD. This proof-of-concept study the effect cannabidiol treatment brain metabolism...
Background/Objectives: Dithiocarbazates (DTCs) and their metal complexes have been studied regarding property as anticancer activities. In this work, using S-benzyl-5-hydroxy-3-methyl-5-phenyl-4,5-dihydro-1H-pirazol-1-carbodithionate (H2bdtc), we prepared [ReO(bdtc)(Hbdtc)] [[99mTc]TcO(bdtc)(Hbdtc)] for tumor uptake animal biodistribution studies. Methods: Re complex was by a reaction of H2bdtc (NBu4)[ReOCl4], the final product characterized IR, 1H NMR, CHN, MS-ESI. 99mTc [[99mTc]TcO4−...
Abstract Background Visual atrophy scales from the medial temporal region are auxiliary biomarkers of neurodegeneration in Alzheimer's disease (AD). Therefore, they may correlate with progression cognitively unimpaired (CU) status to mild cognitive impairment (MCI) and AD, become a valuable tool for diagnostic accuracy. Objective To compare lobe (MTA) entorhinal cortex (ERICA) scores measured through magnetic resonance image (MRI) scans as useful method probable AD diagnosis regarding...
Background: Injection of lysolecithin in the central nervous system results demyelination accompanied by local activation microglia and recruitment monocytes. Positron-emission tomography (PET) imaging, using specific tracers, may be an adequate technique to monitor these events vivo therefore become a tool for monitoring disease progression multiple sclerosis (MS) patients. Objectives: The objective this paper is evaluate potential PET imaging lesions, [ 11 C]MeDAS, C]PK11195 18 F]FDG as...
To compare results of positron emission tomography (PET) with carbon-11-labeled Pittsburgh compound B (11C-PIB) obtained cerebellar or global brain uptake for voxel intensity normalization, describe the cortical sites highest tracer in subjects mild Alzheimer's disease (AD), and explore possible group differences 11C-PIB binding to white matter.11C-PIB PET scans were acquired from AD (n=17) healthy elderly controls (n=19). Voxel-based analysis was performed statistical parametric mapping...
The experimental autoimmune encephalomyelitis model is a of multiple sclerosis that closely mimics the disease characteristics in humans. main hallmarks are neuroinflammation (microglia activation, monocyte invasion, and T-cell infiltration) demyelination. PET imaging may be useful noninvasive technique for monitoring progression drug treatment efficacy vivo.Experimental was induced by myelin-oligodendrocyte glycoprotein immunization female Dark Agouti rats. Experimental rats were imaged at...
Circulating dipeptidyl peptidase IV (DPPIV) activity correlates with cardiac dysfunction in humans and experimental heart failure (HF) models. Similarly, inflammatory markers are associated poorer outcomes HF patients. However, the contributions of DPPIV to inflammation remain elusive. Therefore, this study aimed investigate whether cardioprotective effects inhibition after myocardial injury accompanied by reduced inflammation, circulating levels systemic patients, leukocytes and/or...
Abstract Background We aimed to determine whether a short‐term high‐intensity interval training (HIIT) protocol could counteract tumor progression in an experimental model of lung cancer. Methods Mice were injected subcutaneously with Lewis Lung Carcinoma (LLC) cells and then randomly assigned into two groups: sedentary mice (LLC group) or submitted HIIT + group). Results LLC group had lower mass than (‐52% after 18 days), no differences glycolytic activity as measured by PET/CT imaging....
Pretargeted imaging is shown to be an attractive strategy overcome disadvantages associated with traditional radioimmunoconjugates.