A5089170023- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Medical Imaging Techniques and Applications
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Heart Rate Variability and Autonomic Control
- Bone health and treatments
- Inflammatory Biomarkers in Disease Prognosis
- Immune cells in cancer
- Dietary Effects on Health
- Cardiovascular and exercise physiology
- Medical Imaging and Pathology Studies
- Cancer survivorship and care
- Mitochondrial Function and Pathology
- Sports Performance and Training
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Parkinson's Disease Mechanisms and Treatments
Universidade de São Paulo
2016-2023
We tested the hypothesis that exercise training would attenuate metabolic impairment in a model of severe cancer cachexia.
Abstract Exercise training reduces the incidence of several cancers, but mechanisms underlying these effects are not fully understood. can affect spleen function, which controls hematopoiesis and immune response. Analyzing different cancer models, we identified that 4T1, LLC, CT26 tumor-bearing mice displayed enlarged (splenomegaly), exercise reduced mass toward control levels in two models (LLC CT26). also slowed tumor growth melanoma B16F10, colon 26 (CT26), Lewis lung carcinoma (LLC)...
Abstract Background We aimed to determine whether a short‐term high‐intensity interval training (HIIT) protocol could counteract tumor progression in an experimental model of lung cancer. Methods Mice were injected subcutaneously with Lewis Lung Carcinoma (LLC) cells and then randomly assigned into two groups: sedentary mice (LLC group) or submitted HIIT + group). Results LLC group had lower mass than (‐52% after 18 days), no differences glycolytic activity as measured by PET/CT imaging....
We tested the hypothesis that cancer cachexia progression would induce oxidative post-translational modifications (Ox-PTMs) associated with skeletal muscle wasting, different responses in muscles prevalence of glycolytic and fibers. used cysteine-specific isotopic coded affinity tags (OxICAT) gel-free mass spectrometry analysis to investigate cysteine Ox-PTMs profile proteome both plantaris (glycolytic) soleus (oxidative) tumor-bearing control rats. Histological revealed atrophy type II...
Cancer cachexia is a multifactorial and devastating syndrome characterized by severe skeletal muscle mass loss dysfunction. As still has neither cure nor an effective treatment, better understanding of plasticity in the context cancer great importance. Although aerobic exercise training (AET) been shown as important complementary therapy for chronic diseases associated comorbidities, impact AET on maintenance during progression not well documented yet. Here, we show that previous induced...
Aim: Cardiovascular physiology learned by exercise science students is often quickly forgotten. We tested whether a state rotation model would help to recall key principles of Physiology (CV). Methods: Seventy-one undergraduate enrolled in the Exercise Course at School Physical Education and Sport, University São Paulo, participated study. The were randomly assigned into one 4 stations, dedicated recalling concepts heart as pump (e.g. preload, post-load, contractility; station 1)...