A5054390840- Obstructive Sleep Apnea Research
- Obesity, Physical Activity, Diet
- Nutrition and Health in Aging
- Health and Lifestyle Studies
- Nutritional Studies and Diet
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Body Composition Measurement Techniques
- Healthcare Regulation
- Muscle metabolism and nutrition
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Exercise and Physiological Responses
- Consumer Attitudes and Food Labeling
- Respiratory Support and Mechanisms
- Frailty in Older Adults
- HIV-related health complications and treatments
- Business and Management Studies
- Agricultural and Food Sciences
- Public Health in Brazil
- Cardiovascular and exercise physiology
- Viral gastroenteritis research and epidemiology
- Cardiovascular Health and Disease Prevention
- Muscle Physiology and Disorders
Universidade Federal de Lavras
2020-2025
Harokopio University of Athens
2024
Universidade de São Paulo
2008-2024
Universidade Federal de São Paulo
2011-2021
Harvard University
2017-2018
Circadian (United States)
2017-2018
Brigham and Women's Hospital
2017-2018
Centro de Estudos em Psicologia da Saúde
2013-2015
Universidade São Judas Tadeu
2011
University Gama Filho
2011
Precision medicine for obstructive sleep apnea (OSA) requires noninvasive estimates of each patient's pathophysiological "traits." Here, we provide the first automated technique to quantify respiratory arousal threshold—defined as level ventilatory drive triggering from sleep—using diagnostic polysomnographic signals in patients with OSA. Ventilatory preceding clinically scored arousals was estimated studies by fitting a control model (Terrill et al.) pattern ventilation during spontaneous...
A possible precision-medicine approach to treating obstructive sleep apnoea (OSA) involves targeting ventilatory instability (elevated loop gain) using supplemental inspired oxygen in selected patients. Here we test whether elevated gain and three key endophenotypic traits (collapsibility, compensation arousability), quantified clinical polysomnography, can predict the effect of on OSA severity.36 patients (apnoea-hypopnoea index (AHI) >20 events·h-1) completed two overnight polysomnographic...
Obstructive sleep apnoea (OSA) is characterised by pharyngeal obstruction occurring at different sites. Endoscopic studies reveal that epiglottic collapse renders patients higher risk of failed oral appliance therapy or accentuated on continuous positive airway pressure. Diagnosing currently requires invasive (imaging and endoscopy). As an alternative, we propose can be detected from the distinct airflow patterns it produces during sleep. 23 OSA underwent natural endoscopy. 1232 breaths...
Sleep and exercise have an important role in the development of several inflammation-related diseases, including sarcopenia. Objective: To investigate effects 12 weeks resistance training on sleep inflammatory status sarcopenic patients. Methods: A randomized controlled trial comparing (RET) with a control (CTL) was conducted. Outcomes were obtained by physical tests, polysomnography, questionnaires, isokinetic/isometric dynamometry biochemical analysis. Results: Time to onset (sleep...
Sleep is important for maintenance of skeletal muscle health. debt can induce atrophy by increasing glucocorticoids and decreasing testosterone, growth hormone insulin-like factor-I. These hormonal alterations result in a highly proteolytic environment characterized decreased protein synthesis increased degradation. Given that sleep deprivation increasingly prevalent modern society, strategies to minimize or reverse its adverse effects need be investigated. Resistance exercise has been...
Objective. Describe multicompartmental changes in the fat and various muscle fiber types, as well hormonal profile metabolic rate induced by SD rats. Methods. Twenty adult male Wistar rats were equally distributed into two groups: experimental group (EG) control (CG). The EG was submitted to for 96 h. Blood levels of corticosterone (CORT), total testosterone (TESTO), insulin like growth factor-1 (IGF-1), thyroid hormones (T3 T4) used assess catabolic environment. Muscle trophism measured...
Rationale: The reduction in upper airway muscle activity from wakefulness to sleep plays a key role the development of obstructive apnea. Potassium (K+) channels have been recently identified as downstream mechanisms through which hypoglossal motoneuron membrane excitability is reduced both non-rapid eye movement (NREM) and REM sleep. In animal models, administration 4-aminopyridine (4-AP), voltage-gated K+ channel blocker, increased genioglossus during across all stages.Objectives: We...
Abstract Background We aimed to determine whether a short‐term high‐intensity interval training (HIIT) protocol could counteract tumor progression in an experimental model of lung cancer. Methods Mice were injected subcutaneously with Lewis Lung Carcinoma (LLC) cells and then randomly assigned into two groups: sedentary mice (LLC group) or submitted HIIT + group). Results LLC group had lower mass than (‐52% after 18 days), no differences glycolytic activity as measured by PET/CT imaging....
O presente estudo teve por objetivo avaliar os efeitos do exercício físico em um programa de emagrecimento. Durante 12 semanas, 22 mulheres obesas (IMC>30 kg/m²) foram submetidas a exercícios físicos. Ao início e ao final avaliados: IMC, circunferências da cintura (CC) quadril (CQ), relação cintura/quadril (RCQ); composição corporal DEXA; hemoglobina, eritrócitos, colesterol total, HDL, LDL, triacilgliceróis glicose; potência aeróbia. programa, valores aeróbia, hemácias eritrócitos...
Abstract Background In prostate cancer (PCa), well-established biomarkers such as MSI status, TMB high, and PDL1 expression serve reliable indicators for favorable responses to immunotherapy. Recent studies have suggested a potential association between CDK12 mutations immunotherapy response; however, the precise mechanisms through which mutation may influence immune response remain unclear. A plausible explanation evasion in this subset of -mutated PCa be reduced MHC expression. Results...
In principle, if metabolic rate were to fall during sleep in a patient with obstructive apnea (OSA), ventilatory requirements could be met without increased respiratory effort thereby favoring stable breathing. Indeed, most patients achieve periods of flow-limited breathing events for the night reasons that are unclear. Thus, we tested hypothesis OSA, occur when (VO2) declines. Twelve OSA (apnea–hypopnea index >15 events/h) completed overnight polysomnography including measurements VO2...
Objective: Aging is associated with low-grade systemic inflammation (LGSI), and nutrition has been recognized as a crucial modifiable factor concerning LGSI.The aims of this study are to (i) identify the dietary quality community-dwelling older adults using three approaches; two conventional priori indexes ratio between minimally processed ultra-processed foods (UPR; based on NOVA classification); (ii) explore some differences similarities among (iii) investigate association DII MDS...
RESUMO Objetivo: Fazer uma revisão da literatura sobre a relação entre sono, estado nutricional e padrão alimentar, bem como mecanismos associados, na população infantil. Fontes de dados: Foram realizadas buscas bibliográficas nas bases PubMed, LILACS Scopus, usando os seguintes descritores: “Child”; “Nutritional status”; “Sleep”; “Physical activity OR Physical activities Exercise”. Os artigos que atenderam ao objetivo pesquisa foram incluídos. Excluíram-se estudos revisão, cartas para...
The objective of the present study was to compare and discuss nutritional status older women according different categories BMI. Additionally, aimed at introducing bioelectrical impedance vector analysis (BIVA) as a tool assess status. Thirty-two (60 years or older, physically independent, with moderate level physical activity) were divided into three groups toBMI classification: G1 (BMI<23 Kg/m2); G2 (23<BMI<28 G3 (BMI>28 Kg/ m2). following variables analyzed indicators status:...