A5050969656- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Cancer survivorship and care
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- GDF15 and Related Biomarkers
- Thermal properties of materials
- Free Radicals and Antioxidants
- Receptor Mechanisms and Signaling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Physical Activity and Health
- High Altitude and Hypoxia
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Science and Education Research
- Spaceflight effects on biology
- Protein Kinase Regulation and GTPase Signaling
- Nanoplatforms for cancer theranostics
- Biochemical effects in animals
- Inflammatory Biomarkers in Disease Prognosis
- Frailty in Older Adults
Children's Cancer and Blood Foundation
2020-2024
Cornell University
2020-2024
Universidade de São Paulo
2011-2024
Weill Cornell Medicine
2020-2024
Abstract As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, extracellular vesicles/particles (EVPs) from the SpaceX Inspiration4 crew, we generated “spaceflight secretome profiles,” which showed significant differences in coagulation, oxidative stress, brain-enriched proteins. While >93% differentially abundant proteins (DAPs) vesicles metabolites...
We examined the isolated and combined effects of beta-alanine (BA) sodium bicarbonate (SB) on high-intensity intermittent upper-body performance in judo jiu-jitsu competitors. 37 athletes were assigned to one four groups: (1) placebo (PL)+PL; (2) BA+PL; (3) PL+SB or (4) BA+SB. BA dextrose (placebo) (6.4 g day−1) was ingested for 4 weeks 500 mg kg−1 BM SB calcium carbonate 7 days during 4th week. Before after supplementation, completed 30-s Wingate tests, separated by 3 min. Blood lactate...
Over the past decade, extracellular vesicles and particles (EVPs) have emerged as critical mediators of intercellular communication, participating in numerous physiological pathological processes. In context cancer, EVPs exert local effects, such increased invasiveness, motility, reprogramming tumor stroma, well systemic including pre-metastatic niche formation, determining organotropism, promoting metastasis altering homeostasis various organs systems, liver, muscle, circulatory system....
We tested the hypothesis that exercise training would attenuate metabolic impairment in a model of severe cancer cachexia.
Abstract Exercise training reduces the incidence of several cancers, but mechanisms underlying these effects are not fully understood. can affect spleen function, which controls hematopoiesis and immune response. Analyzing different cancer models, we identified that 4T1, LLC, CT26 tumor-bearing mice displayed enlarged (splenomegaly), exercise reduced mass toward control levels in two models (LLC CT26). also slowed tumor growth melanoma B16F10, colon 26 (CT26), Lewis lung carcinoma (LLC)...
We developed a modified protocol, based on differential ultracentrifugation (dUC), to isolate extracellular vesicles and particles (specifically exomeres) (EVPs) from various human murine sources, including cell lines, surgically resected tumors adjacent tissues, bodily fluids, such as blood, lymphatic fluid, bile. The diversity of these samples requires robust highly reproducible protocols refined isolation technology, asymmetric-flow field-flow fractionation (AF4). Our protocol allows for...
The purpose of this study was to determine the physiological, anthropometric, performance, and nutritional characteristics Brazil Canoe Polo National Team. Ten male canoe polo athletes (age 26.7 ± 4.1 years) performed a battery tests including assessments anthropometric parameters, upper-body anaerobic power (Wingate), muscular strength, aerobic power, profile. In addition, we characterized heart rate plasma lactate responses temporal pattern effort/recovery during simulated match. main...
Abstract Background We aimed to determine whether a short‐term high‐intensity interval training (HIIT) protocol could counteract tumor progression in an experimental model of lung cancer. Methods Mice were injected subcutaneously with Lewis Lung Carcinoma (LLC) cells and then randomly assigned into two groups: sedentary mice (LLC group) or submitted HIIT + group). Results LLC group had lower mass than (‐52% after 18 days), no differences glycolytic activity as measured by PET/CT imaging....
Aerobic exercise training (AET) has emerged as a strategy to reduce cancer mortality, however, the mechanisms explaining AET on tumor development remain unclear. Tumors escape immune detection by generating immunosuppressive microenvironments and impaired T cell function, which is associated with mitochondrial loss. improves content thus we tested whether would modulate metabolism in tumor-infiltrating lymphocytes (TIL). Balb/c mice were subjected treadmill protocol prior CT26 colon...
We investigated the effects of AET on myomiRs expression in skeletal muscle and serum colon cachectic (CT26) breast non-cachectic (MMTV-PyMT) cancer mice models. Colon decreased microRNA-486 expression, increasing PTEN tibialis anterior (TA), decreasing PI3K/mTOR protein pathway, body wasting, fibers’ cross-sectional area dysfunction, that were not preserved by AET. In contrast, those functions, but circulation, downregulation -206 cancer, upregulation microRNA-206 might be good biomarkers....
Cancer cachexia is a multifactorial and devastating syndrome characterized by severe skeletal muscle mass loss dysfunction. As still has neither cure nor an effective treatment, better understanding of plasticity in the context cancer great importance. Although aerobic exercise training (AET) been shown as important complementary therapy for chronic diseases associated comorbidities, impact AET on maintenance during progression not well documented yet. Here, we show that previous induced...
PURPOSE: There are several comorbidities associated with cancer as muscle cachexia. MicroRNAs (miR) in skeletal (myomiRs) has been highly investigated for being related to physiological and pathological factors. Aerobic physical exercise plays an important role the regulation of expression microRNAs. METHODS: We analyzed myomiRs using two mice models MMTV-PyMT (breast cancer, non-cachectic) CT26 (colon cachectic). Animals were running trained divided into 4 groups: SH-sedentary Health;...