Aerobic exercise training leads to a physiological, nonpathological left ventricular hypertrophy; however, the underlying biochemical and molecular mechanisms of physiological hypertrophy are unknown. The role microRNAs regulating classic novel cardiac renin-angiotensin (Ang) system was studied in trained rats assigned 3 groups: (1) sedentary; (2) swimming with protocol 1 (T1, moderate-volume training); (3) 2 (T2, high-volume training). Cardiac Ang I levels, Ang-converting enzyme (ACE)...

Aerobic exercise training (ET) lowers hypertension and improves patient outcomes in cardiovascular disease. The mechanisms of these effects are largely unknown. We hypothesized that ET modulates microRNAs (miRNAs) involved vascularization. miRNA-16 regulates the expression vascular endothelial growth factor antiapoptotic protein Bcl-2. miRNA-21 targets miRNA-126 functions by repressing regulators pathway. investigated whether miRNA-16, -21 -126 modulated ET. Twelve-week-old male...

O tecido muscular esquelético possui a maior massa do corpo humano, com 45% peso total. As lesões musculares podem ser causadas por contusões, estiramentos ou lacerações. A atual classificação separa as entre leve, moderada e grave. Os sinais sintomas das grau I são edema desconforto; II, perda de função, gap equimose eventual; III, rotura completa, dor intensa hematoma extenso. diagnóstico pode confirmado por: ultrassom - dinâmico, barato, porém examinador-dependente; tomografia ressonância...

Objective Obesity and renin angiotensin system (RAS) hyperactivity are profoundly involved in cardiovascular diseases, however aerobic exercise training (EXT) can prevent obesity cardiac RAS activation. The study hypothesis was to investigate whether its association with EXT alter the systemic components an obese Zucker rat strain. Methods rats were divided into following groups: Lean (LZR); lean plus (LZR+EXT); (OZR) (OZR+EXT). consisted of 10 weeks 60-min swimming sessions, 5 days/week. At...

Background: Cartilage restoration is a desperately needed bridge for patients with symptomatic cartilage lesions. Chondral lesion pathology high prevalence, reaching as much 63% of general population and 36% among athletes. Despite autologous chondrocyte implantation versatility, it still fails to fully reproduce hyaline articular characteristics. Mesenchymal stem cells (MSCs) may be isolated from various known tissues, including discarded fragments at arthroscopy such synovial membrane....

IntroductionCartilage lesions and osteoarthritis are very prevalent imply a significant clinical economic burden.MethodsWe performed broad PUBMED database review with sensitive systematized strategy without restriction to article date or type.ResultsThis brings us the aspects of chondral osteochondral throughout different age groups patients. Focusing mainly on surgical treatment, we present here most widely used techniques. To facilitate discussion, patients have been divided into three...

O estudo detalha o monitoramento do volume (m3) de troncos submersos presentes no rio Madeira próximos à Usinas Hidrelétricas (UHE). deposito desse material foi observado ao longo um período na região da bacia adução UHE Jirau. Para a coleta dados utilizado sistema SeeSub®/Venturo acoplado uma embarcação. A atividade detalhou (temporal e espacial) lenhoso depositado das casas força (CF). obtenção ocorreu entre maio 2017 novembro 2022. Quanto total acumulado, analisado por CF, foram...

A presente pesquisa apresenta uma prova de conceito (POC) acionamento remoto e automação das tecnologias sonar. O objetivo foi demostrar a viabilidade dessa tecnologia em termos execução, segurança custo. justificativa é contínua necessidade mitigar possíveis impactos ambientais ecossistemas aquáticos, próximos áreas operação Usinas Hidrelétricas (UHE). utilização do sonar torna possível o mapeamento grandes tempo relativamente curto permite obtenção informações importantes, precisas...

Introduction: Vitamins are essential micronutrients for the body to function. Cobalamins (Cbls) watersoluble compounds, acting as cofactors in enzymatic reactions. However, use of Cbls clinical environment is still controversial. Objective: It was discuss topic and help guide different professionals, experts were brought together criteria concerning diagnosis, indications, cobalamin. Methods: The study carried out using Delphi method. Topics initially created direct discussion initial...

O estudo detalha o monitoramento do volume (m3) de troncos submersos presentes no rio Madeira próximos à Usinas Hidrelétricas (UHE). deposito desse material foi observado ao longo um período na região da UHE Jirau. Para a coleta dados utilizado sistema SeeSub®/Venturo acoplado uma embarcação. é inspeção subaquática que usa tecnologia hidroacústica. Isso possibilitou visualização em única imagem totalidade área inspecionada, tornando verificação integridade estruturas processo seguro e...

Skeletal muscle tissue has the largest mass in human body, accounting for 45% of total weight. Muscle injuries can be caused by bruising, stretching or laceration. The current classification divides such into mild, moderate and severe. signs symptoms grade I lesions are edema discomfort; II, loss function, gaps possible ecchymosis; III, complete rupture, severe pain extensive hematoma. diagnosis confirmed by: ultrasound, which is dynamic cheap, but examiner dependent; tomography magnetic...

Background Although obesity has been associated with metabolic and cardiac disturbances, the carrier mechanisms for these responses are poorly understood. This study analyzed whether angiotensin II blockade attenuates cardiovascular disorders in rats diet-induced obesity. Material Methods Wistar-Kyoto (n = 40) were subjected to control (C; 3.2 kcal/g) hypercaloric diets (OB; 4.6 30 weeks. Subsequently, distributed four groups: C, CL, OB, OBL. L groups received Losartan (30 mg/kg/day) five...

To evaluate the incidence of sports injuries in college athletes from same institution 1993 to 2013.Athletes 13 modalities were interviewed about presence and type injury, treatment time withdrawal, based on questionnaire "Injury Surveillance System" (ISS). Data analyzed with graphs tables injury prevalence by gender, age, site modality. We also average withdrawal athletes, returning practice new lesions.It was observed that 49.91% showed some similar between genders; most frequent anterior...

Chondral lesion is a pathology with high prevalence, reaching as much 63% of general population and 36% among athletes. The ability human Dental Pulp Stem Cells (DPSCs) to differentiate into chondroblasts in vitro suggests that this stem cell type may be useful for tissue bioengineering. However, we have yet identify study large animal models which DPSCs were used repair articular cartilage. Therefore, aimed describe novel treatment cartilage on model.Mesenchymal cells (MSC) obtained from...

What is the central question of this study? are effects exercise training on hepatic renin-angiotensin system and their contribution to damage resulting from fructose overload in rats? main finding its importance? Exercise attenuated deleterious actions angiotensin-converting enzyme/angiotensin II/angiotensin II type 1 receptor axis increased expression counter-regulatory (angiotensin-converting enzyme 2/angiotensin (1-7)/Mas receptor) liver. Therefore, our study provides evidence that...

Skeletal muscle tissue has the largest mass in human body, accounting for 45% of total weight. Muscle injuries can be caused by bruising, stretching or laceration. The current classification divides these into mild, moderate and severe. signs symptoms grade I lesions are edema discomfort; II, loss function, gaps possible ecchymosis; III, complete rupture, severe pain extensive hematoma. diagnosis confirmed ultrasound, which is dynamic cheap, but examiner dependent; magnetic resonance imaging...

ABSTRACT Purpose The beneficial effects of exercise training on the cardiovascular system are well known. Because our knowledge exercise-induced vascular function is still limited, we aimed to uncover molecular mechanisms conditioning improved relaxation in muscular arteries. Methods Male Wistar–Kyoto rats with same ability run a treadmill after maximal tests were allocated following two groups: trained (Tr) (treadmill, 50%–60% capacity, 5 d·wk −1 ) and untrained (UnTr). After 13 wk, femoral...