A5011901374- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hormonal Regulation and Hypertension
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Renin-Angiotensin System Studies
- Cardiac Ischemia and Reperfusion
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Ion Transport and Channel Regulation
- Receptor Mechanisms and Signaling
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Cardiac electrophysiology and arrhythmias
- Hormonal and reproductive studies
- Antioxidant Activity and Oxidative Stress
- Neuropeptides and Animal Physiology
- Cardiovascular Effects of Exercise
- Diabetes Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Muscle metabolism and nutrition
- Mercury impact and mitigation studies
Universidade de São Paulo
2015-2025
Institute of Biomedical Science
2010-2023
GTx (United States)
2009-2023
Institute of Biophysics and Biomedical Engineering
2023
Universidade Federal do Espírito Santo
1997-2016
Universidade Estadual de Campinas (UNICAMP)
2016
Universidad Rey Juan Carlos
2016
Tufts Medical Center
2016
French Clinical Research Infrastructure Network
2015
Université de Lorraine
2015
Hypertensive cardiac remodeling is accompanied by molecular inflammation and fibrosis, 2 mechanisms that finally affect function. At level, aldosterone promotes although the precise are still unclear. Galectin-3 (Gal-3), a β-galactoside–binding lectin, associated with fibrosis in cardiovascular system. We herein investigated whether Gal-3 inhibition could block aldosterone-induced its potential role damage hypertension. Aldosterone-salt–treated rats presented hypertension, inflammation, were...
We investigated the effects of high-fat diet-induced obesity on vascular proinflammatory factors and oxidative stress endothelium-dependent relaxation aorta.Female Swiss mice were submitted to a diet for 16 weeks. At end experimental period, we evaluated blood pressure, in response acetylcholine aortic rings absence presence superoxide anion scavenger, dismutase (SOD, 150 U/ml), nuclear factor (NF)-κB inhibitor, sodium salicylate (5 mmol/l). Aortic protein expression endothelial nitric oxide...
The present study aimed to assess the effect of specific dipeptidyl peptidase IV (DPPIV) inhibitor sitagliptin on blood pressure and renal function in young prehypertensive (5-week-old) adult spontaneously hypertensive rats (SHRs; 14-week-old).Sitagliptin (40 mg/kg twice daily) was given by oral gavage (Y-SHR + IDPPIV) (A-SHR SHRs for 8 days. Kidney assessed daily compared with age-matched vehicle-treated SHR A-SHR) normotensive Wistar-Kyoto (Y-WKY A-WKY). Arterial measured these animals at...
Clinical evidence has identified the pulmonary circulation as an important target of air pollution. It was previously demonstrated that in vitro exposure to fine particulate matter (aerodynamic diameter ≤2.5 μm, PM2.5) induces endothelial dysfunction isolated arteries. We aimed investigate effects vivo urban concentrated PM2.5 on rat artery reactivity and mechanisms involved. For this, adult Wistar rats were exposed 2 weeks São Paulo city at accumulated daily dose approximately 600 μg/m3....
We evaluated the effects of swimming and anabolic steroids (AS) on ventricular function, collagen synthesis, local renin-angiotensin system in rats. Male Wistar rats were randomized into control (C), steroid (S; nandrolone decanoate; 5 mg/kg sc, 2x/wk), + losartan (SL; 20 mg.kg(-1).day(-1)), trained (T), (T+S), (T+SL; n = 14/group) groups. Swimming was performed times/wk for 10 wk. Serum testosterone increased S T+S. Resting heart rate lower T Percent change left (LV) weight-to-body weight...
Abstract Background Obesity has been associated with a variety of disease such as type II diabetes mellitus, arterial hypertension and atherosclerosis. Evidences have shown that exercise training promotes beneficial effects on these disorders, but the underlying mechanisms are not fully understood. The aim this study was to investigate whether physical preconditioning prevents deleterious effect high caloric diet in vascular reactivity rat aortic mesenteric rings. Methods Male Wistar rats...
Previous studies have demonstrated that muscle mechanoreflex and metaboreflex controls are altered in heart failure (HF), which seems to be due changes cyclooxygenase (COX) pathway receptors on afferent neurons, including transient receptor potential vanilloid type-1 (TRPV1) cannabinoid (CB1). The purpose of the present study was test hypotheses: 1) exercise training (ET) alters control sympathetic nerve activity (MSNA) HF patients. 2) alteration is accompanied by increased expression TRPV1...
Background Accumulated evidence shows that the ACE-AngII-AT1 axis of renin-angiotensin system (RAS) is markedly activated in chronic heart failure (CHF). Recent studies provide information Angiotensin (Ang)-(1–7), a metabolite AngII, counteracts effects AngII. However, this balance between AngII and Ang-(1–7) still little understood CHF. We investigated exercise training on circulating skeletal muscle RAS ischemic model Methods/Main Results Male Wistar rats underwent left coronary artery...
Divergent phenotypes between the perivascular adipose tissue (PVAT) surrounding abdominal and thoracic aorta might be implicated in regional aortic differences, such as susceptibility to atherosclerosis. Although PVAT of exhibits anti-contractile function, role regulation vascular tone is not well defined. In present study, we compared nitric oxide (NO) availability, reactive oxygen species (ROS) formation vessel walls aorta. Abdominal from male Wistar rats were used perform functional...
In the microvillar microdomain of kidney brush border, sodium hydrogen exchanger type 3 (NHE3) exists in physical complexes with serine protease dipeptidyl peptidase IV (DPPIV). The purpose this study was to explore functional relationship between NHE3 and DPPIV intact proximal tubule vivo. To end, male Wistar rats were treated an injection reversible inhibitor Lys [Z(NO2)]-pyrrolidide (I40; 60 mg.kg(-1).day(-1) ip) for 7 days. Rats injected equal amounts noninhibitory compound...
We have previously described that chronic administration of ouabain induces hypertension and functional alterations in mesenteric resistance arteries. The aim this study was to analyze whether treatment also alters the structural mechanical properties Wistar rats were treated for 5 wk with (8.0 microg/day sc). vascular structure mechanics third-order branches artery assessed pressure myography confocal microscopy. Total collagen content determined by picrosirius red staining, I/III analyzed...
Cardiovascular disease is less frequent in premenopausal women than age-matched men or postmenopausal women. Moreover, the marked age-related decline serum dehydroepiandrosterone (DHEA) level has been associated to cardiovascular disease. The aim of this study was evaluate effects DHEA treatment on vascular function ovariectomized rats. At 8 weeks age, female Wistar rats were (OVX) sham (SHAM) operated and after surgery both groups treated with vehicle (10mg kg⁻¹ week⁻¹) for 3 weeks. Aortic...
The present study was designed to assess whether cyclooxygenase-2 (COX-2) activation is involved in the effects of chronic aldosterone treatment on endothelial function mesenteric resistance arteries (MRA) from Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR).Relaxation acetylcholine measured MRA both untreated aldosterone-treated strains. Vasomotor responses prostacyclin U46619 were also analysed. Release 6-oxo-prostaglandin (PG)F1alpha thromboxane B2 (TxB2) determined by enzyme...
Background The majority of studies have investigated the effect exercise training (TR) on vascular responses in diabetic animals (DB), but none evaluated nitric oxide (NO) and advanced glycation end products (AGEs) formation associated with oxidant antioxidant activities femoral coronary arteries from trained rats. Our hypothesis was that 8-week TR would alter AGEs levels type 1 rats ameliorating responsiveness. Methodology/Principal Findings Male Wistar were divided into control sedentary...
Statins can have beneficial cholesterol-independent effects on vascular contractility, which may involve increases in the bioavailability of NO (nitric oxide) as a result phosphorylation eNOS (endothelial synthase). Although this has been attributed to Akt (also known protein kinase B), studies cultured cells shown that statins phosphorylate AMPK (AMP-activated kinase); it is unknown whether functional intact arteries. Thus we investigated acute simvastatin resistance arterial contractile...
Background and Purpose Eugenol, a vanilloid molecule found in some dietary plants, relaxes vasculature part via an endothelium‐dependent process; however, the mechanisms involved are unclear. Here, we investigated endothelial cell‐mediated mechanism by which eugenol modulates rat mesenteric artery contractility systemic BP. Experimental Approach The isometric tension of arteries (size 200–300 μ m) was measured using wire myography; non‐selective cation currents ( I Cat ) were recorded cells...
Ouabain (OUA) is a newly recognized hormone that synthesized in the adrenal cortex and hypothalamus. Low doses of OUA can activate signaling pathway by interaction with Na,K-ATPase, which protective against number insults. has central peripheral anti-inflammatory effects. Lipopolysaccharide (LPS), via toll-like receptor 4 activation, widely used model to induce systemic inflammation. This study low dose evaluate its effects on inflammation induced LPS injection rats. Adult male Wistar rats...
Sustained β-adrenergic stimulation is a hallmark of sympathetic hyperactivity in cardiovascular diseases. It associated with oxidative stress and altered vasoconstrictor tone. This study investigated the β-adrenoceptor subtype signaling pathways implicated vascular effects overactivation.Mice lacking β1- or β2-adrenoceptor (β1KO, β2KO) wild-type (WT) were treated isoproterenol (ISO, 15 μg.g(-1) x day(-1), 7 days). ISO significantly enhanced maximal response (Emax) aorta to phenylephrine WT...