A5051330381- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Congenital gastrointestinal and neural anomalies
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Intestinal Malrotation and Obstruction Disorders
- Genomics, phytochemicals, and oxidative stress
- Gastrointestinal disorders and treatments
- Carcinogens and Genotoxicity Assessment
- Amoebic Infections and Treatments
- Gastrointestinal motility and disorders
- MicroRNA in disease regulation
- Digestive system and related health
- Inflammatory mediators and NSAID effects
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Glutathione Transferases and Polymorphisms
- Immune Cell Function and Interaction
- Pneumocystis jirovecii pneumonia detection and treatment
- Veterinary medicine and infectious diseases
- Metastasis and carcinoma case studies
- Galectins and Cancer Biology
- Parasites and Host Interactions
- Pelvic floor disorders treatments
- Diet and metabolism studies
Universidade Estadual Paulista (Unesp)
2015-2024
Vrije Universiteit Brussel
2022
International Isotopes (United States)
2022
Universidade Nova de Lisboa
2021
University of Montenegro
2016
Fundação de Apoio à Universidade Federal de São Paulo
2006-2012
Medecell (Brazil)
2012
Universidade de São Paulo
1992-2004
Universidade Federal de São Paulo
2004
Georgetown University
1988
We investigated the effects of high-fat diet-induced obesity on vascular proinflammatory factors and oxidative stress endothelium-dependent relaxation aorta.Female Swiss mice were submitted to a diet for 16 weeks. At end experimental period, we evaluated blood pressure, in response acetylcholine aortic rings absence presence superoxide anion scavenger, dismutase (SOD, 150 U/ml), nuclear factor (NF)-κB inhibitor, sodium salicylate (5 mmol/l). Aortic protein expression endothelial nitric oxide...
Abstract Coffee intake has been inversely related to the incidence of liver diseases, although there are controversies on whether these beneficial effects human health because caffeine or other specific components in this popular beverage. Thus, study evaluated protective coffee injury induced by repeated thioacetamide ( TAA ) administration male Wistar rats. Rats were randomized into five groups: one untreated group G 1) and four groups 2– 5) treated with hepatotoxicant (200 mg/kg b.w.,...
Yacon (Smallanthus sonchifolius), a tuberous root native to the Andean region of South America, contains high concentration fructans with potential for colon cancer prevention. This study investigated beneficial yacon intake on carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4 weeks DMH-initiation, groups were fed basal diet (G1 and G6) or containing dried extract at 0.5% (G2), 1.0% (G3 G5) synbiotic formulation (G4) (1.0% plus Lactobacillus casei 2.5 ×...
Aberrant crypt foci (ACF) in the colon of carcinogen-treated rodents are considered to be earliest hallmark carcinogenesis. In present study relationship between a short-term (4 weeks) and medium-term (30 assay was assessed model carcinogenesis induced by dimethylhydrazine (DMH) rat. Six-week-old male Wistar rats were given subcutaneous injections DMH (40 mg/kg) twice week for 2 weeks killed at end 4th or 30th week. ACF scored number, distribution pattern along multiplicity 0.1%...
Abstract Propolis is a honeybee product with several biological and therapeutical properties. Its effect on the process of colon carcinogenesis DNA damage were evaluated in male Wistar rats using aberrant crypt foci (ACF) assay comet assay, respectively. For both tests, animals treated carcinogen 1,2 dimethylhydrazine (DMH, 40 mg/kg, s.c.) for 2 weeks (two injections/week) order to induce ACF. The divided into groups that received propolis (ethanolic extract) at three different doses (10,...
A infecção pelo Helicobacter pylori (H. pylori) induz inflamação persistente na mucosa gástrica com diferentes lesões orgânicas em humanos, tais como gastrite crônica, úlcera péptica e câncer gástrico. Os fatores determinantes desses resultados incluem a intensidade distribuição da induzida H. gástrica. Evidências recentes demonstram que cepas do apresentam diversidade genotípica, cujos produtos acionam o processo inflamatório por meio de mediadores citocinas, podem levar graus resposta...
This study investigated the protective effect of oral treatment with lemongrass (Cymbopogon citratus STAPF) essential oil (LGEO) on leukocyte DNA damage induced by N-methyl-N-nitrosurea (MNU). Also, anticarcinogenic activity LGEO was in a multi-organ carcinogenesis bioassay 7,12-dimethylbenz(a)antracene, 1,2-dimethylhydrazine and N-butyl-N-(4-hydroxibuthyl)nitrosamine Balb/C female Balb/c mice (DDB-initiated mice). In short-term study, animals were allocated into three groups: vehicle group...
The aim of the study was to investigate histopathological lesions in upper gastrointestinal mucosa associated with Helicobacter pylori infection children nonulcer dyspepsia.A cross-sectional case-control performed on 185 Brazilian and adolescents (4-17 years, mean 9.5 ± 2.7 years), 63.2% girls, submitted endoscopy. esophageal gastric were analyzed biopsy samples.H identified 96 (51.8%). Moderate severe chronic active gastritis present antrum (70.5%) corpus (45.2%), higher grading than (P <...
PURPOSE: To analyze the epidemiological features of patients with esophageal cancer according to histopathological types: squamous cell carcinoma or adenocarcinoma. METHODS: A total 100 cancer, being 50 carcinomas and adenocarcinomas were analyzed for demographics, nutritional factors, lifestyle habits, benign pathological conditions associated, like Barrett's esophagus megaesophagus, tumor stage survival rates. The factors evaluated included body mass index, percent weight loss, hemoglobin...
Despite progress in treatment strategies, only ~24% of pancreatic ductal adenocarcinoma (PDAC) patients survive >1 year. Our goal was to elucidate deregulated pathways modulated by microRNAs (miRNAs) PDAC and Vater ampulla (AMP) cancers. Global miRNA expression identified 19 PDAC, 6 AMP 25 paired, histologically normal tissues using the GeneChip 4.0 arrays. Computational approaches were used for target prediction/identification miRNA-regulated pathways. Target gene validated 178 cancer 4...
Helicobacter pylori (H. pylori) is considered to predispose carriers gastric cancer but its role on carcinogenesis still unknown. The aim of this study was investigate DNA damage by the comet assay in epithelial cells from antrum and corpus H. pylori-infected patients with gastritis different degrees. status, histology, were studied 62 18 non-infected patients, all them non-smokers, non-alcoholics, non-drug users. significantly higher presenting than normal mucosa. A direct correlation...
Retinopathy, a common complication of diabetes, is characterized by an unbalanced production nitric oxide (NO), process regulated synthase (NOS). We hypothesized that retinopathy might stem from changes in the insulin receptor substrate (IRS)/PI3K/AKT pathway and/or expression NOS isoforms. Thus, we analysed morphology and apoptosis index retinas obese rats whom resistance had been induced high‐fat diet (HFD). Immunoblotting analysis revealed retinal tissue HFD lower levels AKT 1 , eNOS nNOS...