A5100390991- Autophagy in Disease and Therapy
- Ion Channels and Receptors
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Polysaccharides and Plant Cell Walls
- Vestibular and auditory disorders
- RNA modifications and cancer
- interferon and immune responses
- Cancer survivorship and care
- Neuropeptides and Animal Physiology
- Cancer, Stress, Anesthesia, and Immune Response
- Ion channel regulation and function
- Lipid metabolism and biosynthesis
- Acupuncture Treatment Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Ear Surgery and Otitis Media
- Calcium signaling and nucleotide metabolism
- Thyroid Disorders and Treatments
- Sirtuins and Resveratrol in Medicine
- Healthcare and Venom Research
- Thyroid Cancer Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Renal Diseases and Glomerulopathies
Lanzhou Veterinary Research Institute
2023-2025
Chinese Academy of Agricultural Sciences
2023-2025
Lanzhou University
2021-2025
Beijing University of Chinese Medicine
2011-2024
Henan Provincial People's Hospital
2021-2024
Zhengzhou University
2024
Chinese PLA General Hospital
2017-2024
National Clinical Research Center for Digestive Diseases
2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2024
Nanchang University
2023
Mitophagy is a form of autophagy that plays key role in maintaining the homeostasis functional mitochondria cell. Viruses have evolved various strategies to manipulate mitophagy escape host immune responses and promote virus replication. In this study, nucleoprotein (NP) H1N1 (PR8 strain) was identified as regulator mitophagy. We revealed NP-mediated leads degradation mitochondria-anchored protein MAVS, thereby blocking MAVS-mediated antiviral signaling promoting The dependent on interaction...
This study aims to assess the association between body mass index (BMI) and health-related quality of life (HRQOL), further explore gender differences in BMI-HRQOL among adults.
Background and Purpose Eugenol, a vanilloid molecule found in some dietary plants, relaxes vasculature part via an endothelium‐dependent process; however, the mechanisms involved are unclear. Here, we investigated endothelial cell‐mediated mechanism by which eugenol modulates rat mesenteric artery contractility systemic BP. Experimental Approach The isometric tension of arteries (size 200–300 μ m) was measured using wire myography; non‐selective cation currents ( I Cat ) were recorded cells...
Anoctamin-1 [ANO1, also known as transmembrane protein 16A (TMEM16A)] is a Ca(2+)-activated Cl(-) channel expressed in arterial myocytes that regulates membrane potential and contractility. Signaling mechanisms control ANO1 activity are poorly understood. In cerebral artery myocytes, channels activated by local Ca(2+) signals generated plasma nonselective cation channels, but the molecular identity of these proteins unclear. Arterial express several different including multiple members...
We previously reported that Tangshen formula (TSF), a Chinese herbal medicine for diabetic kidney disease (DKD) therapy, imparts renal protective effects. However, the underlying mechanisms of these effects remain unclear. Pyroptosis is form programmed cell death can be triggered by NLRP3 inflammasome. Recently, association between pyroptosis resident cells and DKD was established, but with limited evidence. This study aimed to investigate whether TSF are related its anti-pyroptotic effect....
N 6-methyladnosine (m 6 A) modification is present in both positive- and negative-strand RNA of influenza A virus (IAV) affects the replication pathogenicity IAV. However, little known about regulatory mechanism m IAV RNA. In study, we identified methylation viral different subtypes confirmed that promotes polymerase activity By mutating motifs on multiple RNAs (vRNAs) IAV, revealed deficiency vRNA suppresses expression genes vitro. addition, reduced a mouse model. Mechanistically, assembly...
Tangshen formula (TSF), a of Chinese herbal medicine, improves lipid metabolism in humans and animals with diabetic kidney disease. However, the effect mechanism TSF on nonalcoholic fatty liver disease (NAFLD) remain unclear. The activation autophagy appears to be potential for improving NAFLD. In present study, we examined therapeutic hepatic steatosis sought explore whether its is related activating autophagy. Here, showed that treatment significantly attenuated both high-fat diet (HFD)...
Store-operated Ca(2+) entry (SOCE) is an important influx pathway in non-excitable cells. STIM1, ER sensor, and Orai1, a plasma membrane selective channel, are the two essential components of release activated channel (CRAC) responsible for SOCE activity. Here we explored role STIM1 Orai1 neural differentiation mouse embryonic stem (ES) We found that were expressed functionally active ES cells, expressions dynamically regulated during knockdown inhibited cells into progenitors, neurons,...
Transient potential receptor melastatin-2 (TRPM2) is a non-selective Ca2+-permeable cation channel of the TRPM subfamily and mainly activated by intracellular adenosine diphosphate ribose (ADPR). Here we synthesized 1-(2-nitrophenyl)ethyl caged ADPR (NPE-ADPR) found that uncaging NPE-ADPR efficiently stimulated Ca2+, Mg2+, Zn2+ influx in concentration-dependent manner intact human Jurkat T-lymphocytes. The was inhibited inhibitors or knockdown TRPM2. Likewise, markedly induced entry HEK 293...
Ribosomal DNA (rDNA) transcription drives cell growth and proliferation via the product ribosomal RNA (rRNA), essential component of ribosome. Given fundamental role rRNA in ribosome biogenesis, rDNA has emerged as one effective targets for a number human diseases including various types cancers. In this study, we identify curcumin, an ancient drug, novel natural inhibitor transcription. Curcumin treatment impairs assembly polymerase I preinitiation complex at promoters represses promoter...
Tangshen Formula (TSF) is a Chinese Medicine formula that has been reported to alleviate proteinuria and protect renal function in humans animals with diabetic kidney disease (DKD). However, little known about its mechanism improving proteinuria. The dysregulation of podocyte cell-matrix adhesion demonstrated play an important role the pathogenesis progression proteinuric diseases including DKD. In present study, underlying protective TSF on podocytes was investigated using murine model type...