A5108050380- Plant Molecular Biology Research
- Plant Gene Expression Analysis
- Plant Stress Responses and Tolerance
- Plant Micronutrient Interactions and Effects
- Plant biochemistry and biosynthesis
- Advanced biosensing and bioanalysis techniques
- Photosynthetic Processes and Mechanisms
- Plant-Derived Bioactive Compounds
- Natural product bioactivities and synthesis
- Alzheimer's disease research and treatments
- Vibrio bacteria research studies
- Essential Oils and Antimicrobial Activity
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Advances in Cucurbitaceae Research
- Neurobiology and Insect Physiology Research
- Escherichia coli research studies
- Lipid metabolism and biosynthesis
- Medicinal Plants and Neuroprotection
- Electrochemical Analysis and Applications
- FOXO transcription factor regulation
- Extracellular vesicles in disease
- Phytochemicals and Antioxidant Activities
- Medicinal Plant Research
- Plant Reproductive Biology
Fudan University
2023-2025
Taizhou University
2023-2025
Pudong Medical Center
2025
China Agricultural University
2025
Jilin University
2020-2024
Dalian Ocean University
2023-2024
University of Jinan
2021-2024
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Sun Yat-sen University
2016-2024
Ningbo First Hospital
2024
Surface plasmon resonance imaging (SPRi) is one of the powerful tools for immunoassays with advantages label-free, real-time, and high-throughput; however, it often suffers from limited sensitivity. Herein we report a dual signal amplification strategy utilizing polydopamine (PDA) functionalization reduced graphene oxide (PDA-rGO) nanosheets sensitive SPRi immunoassay in serum. The PDA-rGO nanosheet synthesized by oxidative polymerization dopamine gentle alkaline solution presence (GO)...
VSIG4 controls inflammation through MS4A6D-mediated transcriptional inhibition of Nlrp3 and Il-1 β in macrophages.
Abstract Background The basic/helix-loop-helix (bHLH) transcription factor family exists in all three eukaryotic kingdoms as important participants biological growth and development. To date, the comprehensive genomic functional analyses of bHLH genes has not been reported cucumber ( Cucumis sativus L.). Results Here, a total 142 were identified classified into 32 subfamilies according to conserved motifs, phylogenetic analysis gene structures cucumber. sequences CsbHLH proteins highly based...
Plant male gametogenesis is a coordinated effort involving both reproductive tissues and sporophytic tissues, in which lipid metabolism plays an essential role. Although GDSL esterases/lipases have been well known as key enzymes for many plant developmental processes stress responses, their functions development remain unclear. Here, we report the identification of rice sterile2 (rms2) mutant (Oryza sativa), completely sterile due to defects tapetum degradation, cuticle formation impaired...
Background: Acute lung injury (ALI) is characterized by dysfunction of the alveolar epithelial membrane caused acute inflammation and tissue injury. Qingwenzhike (QWZK) prescription has been demonstrated to be effective against respiratory viral infections in clinical practices, including coronavirus disease 2019 (COVID-19) infection. So far, chemical compositions, protective effects on ALI, possible anti-inflammatory mechanisms remain unknown. Methods: In this study, compositions QWZK were...
Summary Light is known to regulate anthocyanin pigment biosynthesis in plants on several levels, but the significance of protein phosphorylation light‐induced accumulation needs further investigation. In this study, we investigated dynamics apple fruit phosphoproteome response light, using high‐performance liquid chromatography–tandem mass spectrometry analysis. Among differentially phosphorylated proteins, bZIP (basic leucine zipper) transcription factor, HY5, which has been identified as...
Exploration of quantum dots (QDs) as energy acceptors revolutionizes the current chemiluminescence resonance transfer (CRET), since QDs possess large Stokes shifts and high luminescence efficiency. However, strong concentration oxidant (typically H2O2) needed for luminol (CL) reaction could cause oxidative quenching to QDs, thereby decreasing CRET performance. Here we proposed use bienzyme-QDs bioconjugate acceptor improved sensing. Two enzymes, one H2O2 generation (oxidase) another...
Spine colour is an important fruit quality trait that influences the commercial value of cucumber (Cucumis sativus). However, little known about metabolites and regulatory mechanisms their biosynthesis in black spine varieties. In this study, we determined pigments spines are flavonoids, including flavonols proanthocyanidins (PAs). We identified CsMYB60 as best candidate for previously B (Black spine) locus. Expression levels key genes involved flavonoid were higher black-spine inbred lines...
Flavonols and proanthocyanidins (PAs) are the main pigments in black spines of cucumber (Cucumis sativus) fruit, CsMYB60 is a key regulator biosynthesis flavonols PAs. However, cucumber, tissue distribution pattern PAs mechanism their regulated by remain unclear. In this study, we clarified tissue-specific flavonoids unique transcriptional regulation flavonoid cucumber. activated CsFLS CsLAR binding to promoters directly or indirectly promoted expression CsbHLH42, CsMYC1, CsWD40, CsTATA-box...
We previously reported that Tangshen formula (TSF), a Chinese herbal medicine for diabetic kidney disease (DKD) therapy, imparts renal protective effects. However, the underlying mechanisms of these effects remain unclear. Pyroptosis is form programmed cell death can be triggered by NLRP3 inflammasome. Recently, association between pyroptosis resident cells and DKD was established, but with limited evidence. This study aimed to investigate whether TSF are related its anti-pyroptotic effect....
Acute myocardial infarction (AMI) is a common disease leading threat to human health around the world. Here we aimed explore new biomarkers and potential therapeutic targets in AMI through adopting integrated bioinformatics tools.The gene expression Omnibus (GEO) database was used obtain genes data of no-AMI whole blood. Furthermore, differentially expressed (DEGs) were screened using "Limma" package R 3.6.1 software. Functional pathway enrichment analyses DEGs performed via "Bioconductor"...
The change in the characteristics of gut microbiota is linked to gestational diabetes mellitus (GDM). However, whether and how microbiota-derived metabolites GDM uncertain. Here, we aimed determine associations between GDM.
Cold stress is one of the main abiotic stresses limiting cucumber (Cucumis sativus L.) growth and production. C-repeat binding factor/Dehydration responsive element-binding 1 protein (CBF/DREB1), containing conserved APETALA2 (AP2) DNA domains two characteristic sequences, are key signaling genes that can be rapidly induced play vital roles in plant response to low temperature. However, CBF family has not been systematically elucidated cucumber, expression pattern this under cold remains...
Cyclic di-GMP (c-di-GMP) is a second messenger that transduces extracellular stimuli into cellular responses and regulates various biological processes in bacteria. H-NS global regulatory protein represses expression of many genes, but how activity modulated by environmental signals remains largely unclear. Here, we show high intracellular c-di-GMP levels, induced cues, relieve H-NS-mediated transcriptional silencing Salmonella enterica serovar Typhimurium. We find binds to the inhibit its...
25-Hydroxycholesterol (25HC) is a hydroxylated cholesterol with multiple antiviral activities, however, little known about the mechanisms by which 25HC correlates ability lipid droplet (LD) dynamic balance to ensure homeostasis. In present study, was applied porcine deltacoronavirus (PDCoV)-infected LLC-PK1 (Lilly Laboratories Culture-Porcine Kidney 1) cells and piglets explore its capacity underlying mechanism. The results revealed that decreased free (FC) levels but increased triglyceride...
Abstract One of the key limitations microelectrode techniques for recording neuronal circuit activity is their lack inherent selectivity specific cell types. This issue expected to be addressed by utilizing synapse organizers that induce synapse-like junctions onto microelectrodes in a type-specific manner. In this study, we developed an orthogonal set engineered with peptide ligands, each designed activated exclusively through interaction its corresponding nanobody. These molecular tools...
Metabolic malnutrition and inflammation-key mechanism links to redox imbalance-are fundamental pathologies that accelerate aging disease progression, ultimately leading death. The recently proposed metabolic vulnerability index (MVX) integrates multiple circulatory biomarkers closely linked both inflammatory factors. This study aims assess MVX's potential predict mortality in community-based population. In this large prospective study, we included UK Biobank participants who underwent plasma...
Abstract Background Leaf color is an important ornamental trait of colored-leaf plants. The change leaf closely related to the synthesis and accumulation anthocyanins in leaves. Acer pseudosieboldianum a tree native Northeastern China, however, there was less knowledge about biosynthesis many steps pathway remain unknown date. Results Anthocyanins metabolite transcript profiling were conducted using HPLC ESI-MS/MS system high-throughput RNA sequencing respectively. results demonstrated that...
Abstract Drug repurposing of non-cancer drugs represents an attractive approach to develop new cancer therapy. Using the TRAMP transgenic mouse model, glipizide, a widely used drug for type 2 diabetes mellitus, has been identified suppress prostate (PC) growth and metastasis. Angiogenesis is intimately associated with various human developments. Intriguingly, glipizide significantly reduces microvessel density in PC tumor tissues, while not inhibiting cell proliferation from MTT assay flow...