A5076904989- Mass Spectrometry Techniques and Applications
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Essential Oils and Antimicrobial Activity
- Bioinformatics and Genomic Networks
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Nutritional Studies and Diet
- Ferroptosis and cancer prognosis
- Natural product bioactivities and synthesis
- Diet and metabolism studies
- Analytical Chemistry and Chromatography
- Plant biochemistry and biosynthesis
- Medicinal Plants and Neuroprotection
- Microbial Natural Products and Biosynthesis
- Diet, Metabolism, and Disease
- Phytochemicals and Antioxidant Activities
- Ovarian function and disorders
- Gut microbiota and health
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
Chinese Center For Disease Control and Prevention
2022-2025
Sichuan University
2022-2025
West China Hospital of Sichuan University
2022-2025
Northwest A&F University
2020-2025
Xinyang Normal University
2023-2024
Peking University
2024
Beijing Academy of Artificial Intelligence
2024
Nanjing University of Aeronautics and Astronautics
2024
Ministry of Industry and Information Technology
2024
Qiqihar Medical University
2021-2023
Background and AimsObesity insulin resistance are associated with left ventricular diastolic dysfunction (LVDD) increased risk of heart failure.Cardiometabolic index (CMI) triglyceride glucose (TyG) new indexes to assess visceral obesity resistance, respectively.The study aimed investigate the clinical usefulness these for identifying LVDD individuals. Methods ResultsOverall, 1898 asymptomatic individuals were included in this cross-sectional study.Participants underwent anthropometrics,...
DNA methylation is a key epigenetic mark that critical for gene regulation in multicellular eukaryotes. Although various human cell types may have the same genome, these cells different methylomes. The systematic identification and characterization of marks across are crucial to understand complex regulatory network fate determination. In this study, we proposed an entropy-based framework termed SMART integrate whole genome bisulfite sequencing methylomes 42 tissues/cells identified 757 887...
Abstract This study investigates the Dynamic Coupling between Land Use Economic Efficiency (LUEE) and Urban Ecological Resilience (UER) in Yellow River Basin (YRB). exploration is pivotal for elucidating interaction mechanisms economic growth ecological governance. Furthermore, understanding this relationship essential fostering high-quality, sustainable urban development YRB. Utilizing panel data from 56 cities spanning 2003 to 2020, employed coupling coordination degree (CCD) model,...
Torreya grandis Fort. ex Lindl. is a plant belonging to the Taxaceae family and cv. Merrillii only grafted thoroughbred species this species. In study, we extracted five different seed oils, including T. oil (TGSO), "Xiangyafei" (XYSO), "Zhimafei" (ZMSO), "Majus"seed (TGMSO), "cunguangfei" (CGSO) using physical pressure. The resulting extracts were analyzed determine their fatty acid composition, antioxidant activity, inhibitory activity towards tyrosinase. results of assays revealed that...
Danhong injection (DHI), which is one of the most well-known Traditional Chinese Medicine (TCM) injections, widely used to treat unstable angina (UA). However, its underlying pharmacological mechanisms need be further clarified.In present study, network pharmacology was adopted. Firstly, relative compounds were obtained by a wide-scaled literatures-mining and potential targets these target fishing collected. Then, we built UA database DisGeNET, DigSee, TTD, OMIM. Based on data,...
Yinzhihuang granules (YZHG) is a patented Chinese medicine for the treatment of hepatitis B. This study aimed to investigate intrinsic mechanisms YZHG in B and provide new evidence insights its clinical application. The chemical compounds were searched CNKI PUBMED databases, their putative targets then predicted through search SuperPred Swiss Target Prediction databases. In addition, obtained from TTD, PharmGKB DisGeNET. abovementioned data visualized using Cytoscape 3.7.1, network...
Acute myocardial infarction (AMI) is a common disease leading threat to human health around the world. Here we aimed explore new biomarkers and potential therapeutic targets in AMI through adopting integrated bioinformatics tools.The gene expression Omnibus (GEO) database was used obtain genes data of no-AMI whole blood. Furthermore, differentially expressed (DEGs) were screened using "Limma" package R 3.6.1 software. Functional pathway enrichment analyses DEGs performed via "Bioconductor"...
This study aimed to assess the association of dietary fiber intake with serum uric acid (SUA) levels and risk hyperuricemia (HUA) among Chinese adults using latest nationally representative data. A total 66,427 aged 18 years over from China Adult Chronic Disease Nutrition Surveillance in 2015 were included this study. Dietary intakes measured a 3-day 24 h recall household condiment weighing method. Mixed-effect linear logistic regression models used evaluate associations SUA HUA,...
Objective This study aimed to evaluate the relationship between weight-adjusted waist circumference index (WWI) and frailty in American adults aged over 60 years. Methods We utilized data from National Health Nutrition Examination Surveys (NHANES) spanning 2007 2018. WWI was calculated using square root of (cm) divided by body weight (kg). The ≥ 0.25 employed assess frailty. Weighted multivariate logistic regression conducted explore association Generalized Additive Modeling (GAM) used...
Background: Sarcopenia associated with aging severely affects the quality of life elderly; diets have been shown to elicit an inflammatory response in body, and that promote inflammation may lead damage muscles. The Dietary Inflammatory Index (DII) has developed quantify potential individual diets. Therefore, this study aimed investigate association between DII, sarcopenia its components elderly Chinese people. Methods: In study, data were obtained from China Nutrition Improvement Strategies...
Vast rural populations squeezed into cities, leaving small townships hollowed out. Even so, some townships’ lands are still expanding. The dilemma of land expansion with a shrinking population raises various challenges including farmland reduction. Much the current research on impervious has focused urban areas, while were often neglected. Based high-resolution satellite data and statistic in 1993–2018, this study explored long-term township dynamics real-world relationship their for 17...
Background Sarcopenia is prevalent in older adults and not only severely affects their health, but also brings a greater economic burden on the patient’s family as well society. High-quality diet one of influencing factors sarcopenia, particularly important for muscle mass function. This study aims to examine dietary patterns community-dwelling typical region China explore relationship between these sarcopenia. Methods We used data Nutrition Health Follow-up Study Chinese Population 2021....
To investigate the possible association between pan-immune-inflammation value (PIV) and dyslipidemia. This cross-sectional study used data obtained from National Health Nutrition Examination Survey (NHANES). The independent variable logarithmic form of PIV-log2 (PIV). definition dyslipidemia was based on Cholesterol Education Program standards. Weighted multivariate logistic regression analyses, restricted cubic spline (RCS) threshold effect analysis were explore PIV Stratified analyses to...
Heterostyly is a polymorphic floral adaptation controlled by supergenes and maintained in populations disassortative mating. The molecular basis of distyly has been investigated several unrelated families. Previous studies have limited to diploid species not included Rubiaceae, which the highest number heterostylous species. Here, we investigate genetic architecture tetraploid Schizomussaenda henryi (Rubiaceae) identify candidate style-length genes, evidence for hemizygosity potential role...
Abstract Arterial stiffness is a critical factor in cardiovascular and cerebrovascular events, yet clinical practice lacks specific therapeutic targets biomarkers for its assessment. Hyperlipidemia closely correlates with arterial stiffness, we observed elevated CCAAT/enhancer-binding protein β (C/EBPβ) expression atherosclerotic mouse walls. As the medial layer predominantly consists of vascular smooth muscle cells (VSMCs), C/EBPβ‘s role VSMCs under hyperlipidemia remains unclear. Our...
The construction of ecological networks and the optimization spatial layouts are essential for maintaining regional security promoting sustainable development, especially in high-population-density urban agglomerations. This study employs Central Plains Urban Agglomeration (CPUA) as a case to establish an network through quantitative assessments land use/cover change (LUCC) ecosystem service value (ESV), utilizing morphological pattern analysis (MSPA) methods tools such Linkage Mapper...
Reduning injection (RDNI) is a patented Traditional Chinese medicine that contains three herbal medicines, respectively are the dry aboveground part of Artemisia annua L., flower Lonicera japonica Thunb., and fruit Gardenia jasminoides J.Ellis. RDNI has been recommended for treating Coronavirus Disease 2019 (COVID-19) in "New Pneumonia Diagnosis Treatment Plan".To elucidate verify underlying mechanisms treatment COVID-19.This study firstly performed anti-SARS-CoV-2 experiments Vero E6 cells....
Abstract Compound Kushen injection (CKI), a medicine in widespread clinical use China, has proven therapeutic effects on cancer. However, few molecular mechanism analyses have been carried out. To address this problem, bioinformatics approaches combining weighted gene co-expression network analysis with pharmacology methods were undertaken to elucidate the underlying mechanisms of CKI treatment esophageal cancer (ESCA). First, key modules related traits ESCA analysed by WCGNA. Based results,...
To investigate the association between duration of disability in activity daily living (ADL) and overall survival older individuals. A prospective cohort study. Community-based data from Chinese Longitudinal Healthy Longevity Survey. In total, 13,560 participants without ADL 2772 with at baseline were included. was assessed using Katz index scale, which included six essential ADLs: dressing, bathing, transferring, toileting, continence, eating. Dependence each item scored on a scale 1,...
Understanding the computational mechanisms that underlie encoding and decoding of environmental stimuli is a crucial investigation in neuroscience. Central to this pursuit exploration how brain represents visual information across its hierarchical architecture. A prominent challenge resides discerning neural underpinnings processing dynamic natural scenes. Although considerable research efforts have been made characterize individual components pathway, systematic understanding distinctive...