A5079475177- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Wound Healing and Treatments
- Venous Thromboembolism Diagnosis and Management
- Genomics and Phylogenetic Studies
- Cancer Genomics and Diagnostics
- Genetic diversity and population structure
- Bipolar Disorder and Treatment
- Forest Insect Ecology and Management
- Acute Ischemic Stroke Management
- Adenosine and Purinergic Signaling
- Tryptophan and brain disorders
- Genomics and Chromatin Dynamics
- Fibroblast Growth Factor Research
- Dermatologic Treatments and Research
- Coronary Interventions and Diagnostics
- Cancer-related gene regulation
Harbin Medical University
2015-2024
Jinan University
2024
BGI Group (China)
2023
BGI Genomics
2023
DNA methylation is a key epigenetic mark that critical for gene regulation in multicellular eukaryotes. Although various human cell types may have the same genome, these cells different methylomes. The systematic identification and characterization of marks across are crucial to understand complex regulatory network fate determination. In this study, we proposed an entropy-based framework termed SMART integrate whole genome bisulfite sequencing methylomes 42 tissues/cells identified 757 887...
Tumour heterogeneity describes the coexistence of divergent tumour cell clones within tumours, which is often caused by underlying epigenetic changes. DNA methylation commonly regarded as a significant regulator that differs across cells and tissues. In this study, we comprehensively reviewed research progress on estimating heterogeneity. Bioinformatics-based analysis has revealed evolutionary relationships between breast cancer lines Further profiles in 33 cancer-related identified...
Depression is a prevalent psychiatric disorder with accumulating evidence implicating dysregulation of extracellular adenosine triphosphate (ATP) levels in the medial prefrontal cortex (mPFC). It remains unclear whether facilitating endogenous ATP production and subsequently increasing level mPFC can exert prophylactic effect against chronic social defeat stress (CSDS)-induced depressive-like behaviors enhance resilience. Here, we found that nicotinamide mononucleotide (NMN) treatment...
Superficial erosion accounts for approximately one-third of all cases acute coronary syndrome (ACS). Previously, we found that a nearby bifurcation is independently associated with superficial erosion; however, the effect long-term oscillatory flow on remains unexplored. Endothelial-to-mesenchymal transition (EndMT) dynamic process in which endothelial cells acquire mesenchymal properties and, turn, give rise to smooth muscle cell (SMC)-like and extracellular matrix (ECM) accumulation,...
Abstract Sympatric speciation (SS) refers to the origin of new species within a freely breeding population. The ‘Evolution Canyon’ (EC) in Israel is natural microsite model for SS across phylogenies from viruses and bacteria mammals, adapting to, speciating in, interslope microclimates. cosmopolitan Drosophila melanogaster at EC I, Mount Carmel, undergoing incipient response sharply divergent microclimate stresses, including solar radiation, temperature, humidity pathogenicity. We...