A5086543671- Gut microbiota and health
- Biofuel production and bioconversion
- Meat and Animal Product Quality
- Metabolomics and Mass Spectrometry Studies
- Genomics and Phylogenetic Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Ruminant Nutrition and Digestive Physiology
- Microbial Metabolic Engineering and Bioproduction
- Lymphoma Diagnosis and Treatment
- Diet and metabolism studies
- Analytical Chemistry and Chromatography
- Gastrointestinal motility and disorders
- Plant Virus Research Studies
- Plant-Microbe Interactions and Immunity
- Genetic and phenotypic traits in livestock
- Analytical chemistry methods development
- Bacteriophages and microbial interactions
- Clostridium difficile and Clostridium perfringens research
- Autoimmune and Inflammatory Disorders Research
- Kruppel-like factors research
- Fungal and yeast genetics research
- Catalysis for Biomass Conversion
- Acute Ischemic Stroke Management
- Insect Pest Control Strategies
Qinghai University
2020-2025
First Affiliated Hospital of Zhengzhou University
2013-2025
Kangmei Pharmaceutical (China)
2022-2025
Zhuhai Institute of Advanced Technology
2025
Shandong University
2013-2024
BGI Group (China)
2011-2023
State Key Laboratory of Microbial Technology
2015-2023
BGI Genomics
2023
Wuhan No.1 Hospital
2021-2023
Institut de Biologie Moléculaire des Plantes
2023
The mouse-sized naked mole rat (Heterocephalus glaber) is a very unusual mammal. It social animal, living in groups burrows beneath arid African deserts. can live for 30 or more years atmospheres with low oxygen and high carbon dioxide, remarkably resistant to cancer. So the genome sequence, published this issue, might be expected contain some intriguing characteristics. Analysis of its transcriptome reveals genomic features molecular adaptations including strategies improved stability,...
Locusts are one of the world's most destructive agricultural pests and represent a useful model system in entomology. Here we present draft 6.5 Gb genome sequence Locusta migratoria, which is largest animal sequenced so far. Our findings indicate that large size L. migratoria likely to be because transposable element proliferation combined with slow rates loss for these elements. Methylome transcriptome analyses reveal complex regulatory mechanisms involved microtubule dynamic-mediated...
Spiders are ecologically important predators with complex venom and extraordinarily tough silk that enables capture of large prey. Here we present the assembled genome social velvet spider a draft assembly tarantula represent two major taxonomic groups spiders. The genomes short exons long introns, reminiscent mammalian genomes. Phylogenetic analyses place spiders ticks as sister supporting polyphyly Acari. Complex sets genes/proteins identified. We find genes evolved by sequential...
The asexual fungus Fusarium oxysporum f. sp. cubense (Foc) causing vascular wilt disease is one of the most devastating pathogens banana (Musa spp.). To understand molecular underpinning pathogenicity in Foc, genomes and transcriptomes two Foc isolates were sequenced.
An excess of fecal bile acids (BAs) is thought to be one the mechanisms for diarrhea-predominant irritable bowel syndrome (IBS-D). However, factors causing excessive BA excretion remain incompletely studied. Given importance gut microbiota in metabolism, we hypothesized that dysbiosis might contribute IBS-D. By performing BA-related metabolic and metagenomic analyses 290 IBS-D patients 89 healthy volunteers, found 24.5% exhibited total BAs alteration BA-transforming bacteria feces. Notably,...
Background:The pig is an economically important food source, amounting to approximately 40% of all meat consumed worldwide. Pigs also serve as model organism because their similarity humans at the anatomical, physiological and genetic level, making them very useful for studying a variety human diseases. A strain particular interest miniature pig, specifically Wuzhishan (WZSP), it has been extensively inbred. Its high level homozygosity offers increased ease selective breeding specific traits...
Abstract Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, IBS-specific microbiota, metabolites, their interactions remain poorly understood. To address this issue, we performed metabolomic metagenomic profiling stool serum samples based on discovery (n = 330) validation 101)...
This study aims to determine the impact of dietary energy levels on rumen microbial composition and its relationship quality Black Tibetan sheep meat by applying metabolomics Pearson's correlation analyses. For this purpose, UHPLC-QTOF-MS was used identify metabolome, whereas 16S rDNA sequencing detect microbiota. Eventually, we observed that high diet group (HS) improved carcass fat deposition in longissimus lumborum (LL) compared medium (MS). However, HS considerably increased texture,...
Introduction Black Tibetan sheep is one of the primitive breeds in China that famous for its great eating quality and nutrient value but with little attention to relationship between feeding regimes rumen metabolome along impact on muscle metabolism meat quality. Methods This study applies metabolomics-based analyses muscles 16S rDNA-based sequencing fluid examine how influence composition microbiota, ultimately from sheep. Twenty-seven rams were randomly assigned either indoor conditions...
Abstract The gut microbiota influences host immunity and metabolism, changes in its composition function have been implicated several non‐communicable diseases. Here, comparing germ‐free (GF) specific pathogen‐free (SPF) mice using spatial transcriptomics, single‐cell RNA sequencing, targeted bile acid metabolomics across multiple organs, we systematically assessed how the microbiota's absence affected organ morphology, immune homeostasis, acid, lipid metabolism. Through integrated analysis,...
Somatic calreticulin (CALR), Janus kinase 2 (JAK2), and thrombopoietin receptor (MPL) mutations essentially show mutual exclusion in myeloproliferative neoplasms (MPN), suggesting that they activate common oncogenic pathways. Recent data have shown MPL function is essential for CALR mutant-driven MPN. However, the exact role mechanisms of action mutants not been fully elucidated. The murine myeloid cell line 32D human HL60 cells overexpressing most frequent type 1 frameshift were generated...
Treatment with sodium tanshinone IIA sulfonate (STS) may ameliorate blood-brain barrier (BBB) damage in acute ischemic stroke patients receiving recombinant tissue plasminogen activator (rt-PA) thrombolysis and improve patients' outcome. This randomized, single-center, placebo-controlled clinical trial investigated the potential effects underlying mechanisms of STS. Forty-two intravenous rt-PA were randomized to administration either STS (60 mg/day) (n = 21) or equivalent volume saline as a...
Abstract Genome-wide analysis of genomic signatures might reveal novel mechanisms for gastric cancer (GC) tumorigenesis. Here, we structural variations (SVs) and mutational via whole-genome sequencing 168 GCs. Our data demonstrates diverse models complex SVs operative in GC, which lead to high-level amplification oncogenes. We find varying proportion tandem-duplications (TDs) among individuals identify 24 TD hotspots involving well-established genes such as CCND1, ERBB2 MYC . Specifically,...
Rhubarb enema could effectively alleviate the progression of chronic kidney disease (CKD), however, specific mechanism remains unclear. We previously reported a reduction uremic toxins, oxidative stress and inflammation after rhubarb intervention which may related to gut microbiota modification. However, whether protects intestinal barrier by regulating in CKD Here we further investigated effects on microbiota, renal function 5/6 nephrectomy animal model. Our results indicated that regulated...
Rationale: An elevated level of plasma LDL (low-density lipoprotein) is an established risk factor for cardiovascular disease. Recently, we reported that the (pro)renin receptor ([P]RR) regulates metabolism in vitro via LDLR (LDL receptor) and SORT1 (sortilin-1), independently renin–angiotensin system. Objectives: To investigate physiological role (P)RR lipid vivo. Methods Results: We used N-acetylgalactosamine modified antisense oligonucleotides to specifically inhibit hepatic expression...
Palm kernel meal (PKM) has been shown to be a high-quality protein source in ruminant feeds. This study focused on the effects of feed, supplemented with different amounts PKM (ZL-0 as blank group, and ZL-15, ZL-18, ZL-21 treatment group), quality flavor profile Tibetan sheep meat. Furthermore, deposition beneficial metabolites composition rumen microorganisms underlying regulatory mechanisms meat were studied based ultra-performance liquid chromatography coupled quadrupole time-of-flight...
Extranodal natural killer/T-cell lymphoma (ENKL) is marked by a profound cellular immune deficiency that may influence the capacity of T cells to extract an efficient antitumor response. It has been confirmed B7-CD28 pathway promote tumor evasion providing negative regulatory signal. The current study analyzed expression programmed death 1 (PD-1)/programmed ligand (PD-L) in ENKL cell lines and tissues. functional studies were performed analyze activity PD-L1 interacting with effective ENKL....
Natural killer/T cell lymphoma (NKTCL) is an aggressive with a poor prognosis. Chimeric antigen receptor-transduced T (CAR-T) therapy has become promising immunotherapeutic strategy against haematologic malignancies.In this study, four CAR-T lines (CD38-CAR, LMP1-CAR, CD38-LMP1 tandem CAR 1 and 2) were generated. The effect of cells NKTCL was evaluated both in vitro vivo. Expression activation markers cytokines produced by detected flow cytometry.The could effectively eliminate malignant...
The significant anatomical changes in large intestine of germ-free (GF) mice provide excellent material for understanding microbe-host crosstalk. We observed differences GF and physiological involving enlarged cecum, thinned mucosal layer enriched water cecal content. Furthermore, integration analysis multi-omics data revealed the associations between structure intestinal mesenchymal cells thinning layer. Increased