A5042002981- Protein Interaction Studies and Fluorescence Analysis
- Immune Response and Inflammation
- Antifungal resistance and susceptibility
- Meat and Animal Product Quality
- COVID-19 and Mental Health
- Cancer-related molecular mechanisms research
- Ruminant Nutrition and Digestive Physiology
- Viral gastroenteritis research and epidemiology
- Ubiquitin and proteasome pathways
- Antibiotic Use and Resistance
- Blood properties and coagulation
- COVID-19 Pandemic Impacts
- Dengue and Mosquito Control Research
- Parasite Biology and Host Interactions
- Fungal Infections and Studies
- Occupational and environmental lung diseases
- Malaria Research and Control
- interferon and immune responses
- COVID-19 epidemiological studies
- Toxin Mechanisms and Immunotoxins
- Inflammation biomarkers and pathways
- Parasites and Host Interactions
- Mosquito-borne diseases and control
- Circular RNAs in diseases
- Infection Control and Ventilation
Qassim University
2022-2024
James Graham Brown Foundation
2019
University of Louisville
2018-2019
Palm kernel meal (PKM) has been shown to be a high-quality protein source in ruminant feeds. This study focused on the effects of feed, supplemented with different amounts PKM (ZL-0 as blank group, and ZL-15, ZL-18, ZL-21 treatment group), quality flavor profile Tibetan sheep meat. Furthermore, deposition beneficial metabolites composition rumen microorganisms underlying regulatory mechanisms meat were studied based ultra-performance liquid chromatography coupled quadrupole time-of-flight...
MicroRNAs (miRNAs) are involved in the modulation of pathogenic genes by binding to their mRNA sequences’ 3′ untranslated regions (3′UTR). Interleukin-6 (IL-6) is known promote cancer progression and treatment resistance. In this study, we aimed explore therapeutic effects gold nanoparticles (GNP) against IL-6 overexpression miRNA-26a-5p breast (BC) cells. GNP were synthesized using trisodium citrate method characterized through UV-Vis spectroscopy, dynamic light scattering (DLS),...
Abstract Silicosis is a lung inflammatory disease caused by chronic exposure to crystalline silica (CS). Leukotriene B4 (LTB4) plays an important role in neutrophilic inflammation, which drives silicosis and promotes cancer. In this study, we examined the mechanisms involved CS-induced pathways. Phagocytosis of CS particles essential for production LTB4 IL-1β mouse macrophages, mast cells, neutrophils. Phagosomes enclosing trigger assembly lipidosome cytoplasm, likely primary source...
High aspect ratio zinc oxide nanowires (ZnONWs) have become one of the most important products in nanotechnology. The wide range applications ZnONWs heightened need for evaluating risks and biological consequences to these particles. In this study, we investigated inflammatory pathways activated by cultured cells as well systemic exposure mouse models. Confocal microscopy showed rapid phagocytic uptake FITC-ZnONWs macrophages. Exposure macrophages or lung epithelial induced production CCL2...
Abstract Xylanase, an exogenous enzyme that plays essential role in energy metabolism by hydrolysing xylan into xylose, has been shown to positively influence nutrient digestion and utilisation ruminants. The objective of this study was evaluate the effects xylanase supplementation on back‐fat thickness, fatty acid profiles, antioxidant capacity, differentially expressed genes (DEGs) subcutaneous fat Tibetan sheep. Sixty three‐month‐old rams with average weight 19.35 ± 2.18 kg were randomly...
Rotavirus, a dsRNA virus in the Reoviridae family, shows segmented genome. The VP1 gene encodes RNA-dependent RNA polymerase (RdRp). This study aims to develop multiepitope-based vaccine targeting RdRp using immunoinformatic approaches. In this study, 100 available nucleotide sequences of VP1-Rotavirus belonging different strains across world were retrieved from NCBI database. selected aligned, and global consensus sequence was developed by CLC work bench. involved approaches molecular...
Hereditary spherocytosis (HS) is the most common hereditary hemolytic disorder induced by red blood cell (RBC) membrane defect. This study was undertaken to determine mutations in genes associated with RBC defect patients HS such as α-spectrin gene (SPTA1), β-spectrin (SPTB), ankyrin (ANK1), band 3 anion transport (SLC4A1) and erythrocyte protein 4.1 (EPB41). Blood samples were collected from 23 unrelated HS. Patients diagnosed according guidelines British Society for Hematology. All...
The innate immune system is the main and first line of defense mechanism present in human body, which acts against a foreign antigen. To function it utilize several mechanisms, among those are primary one recognizing antigen accomplished via decidedly complicated group molecules termed as pattern recognition receptors (PRRs), perceive various diverse structures on pathogen known pathogen-associated molecular patterns (PAMPs). PRPs include classes receptors’, functions, nature these vary from...
BACKGROUND: The coronavirus disease 2019 (COVID-19) is a global public health disaster and knowledge of its associated risk factors provides protection/slowdown against transmission. AIM: This study was undertaken to investigate all major with transmission the COVID-19 infection. METHODS: data on for were collected from Texas Medical Association, Center Disease Prevention Control, World Health Organization, Safety Executive. combined, analyzed, presented as percentage mean ± SD. RESULTS:...
Objective: This study was undertaken to elaborate the precautionary methods taken by College of Medicine Qassim University for conduction students’ academic examinations (exams) in university campus during COVID-19 pandemic. Methods: conducted on undergraduate medical students (n=674) from September 2020 April 2021 at University. The switch into conducting exams within center managed exam committee. Multiple online workshops were staff and regarding measures procedures order prevent...