A5063517900- Microbial Metabolic Engineering and Bioproduction
- Microbial metabolism and enzyme function
- Biofuel production and bioconversion
- Scientific Computing and Data Management
- Research Data Management Practices
- Biochemical Acid Research Studies
- Biomedical Text Mining and Ontologies
- Genomics and Phylogenetic Studies
- Semantic Web and Ontologies
- School Health and Nursing Education
- Mitochondrial Function and Pathology
- Probiotics and Fermented Foods
- Machine Learning in Bioinformatics
- Mesoporous Materials and Catalysis
- Viral Infectious Diseases and Gene Expression in Insects
- Bacterial Genetics and Biotechnology
- Evolution and Paleontology Studies
- Medical Research and Treatments
- Dental Health and Care Utilization
- Food Quality and Safety Studies
- Species Distribution and Climate Change
- Environmental Monitoring and Data Management
- RNA and protein synthesis mechanisms
- Pharmacological Effects of Natural Compounds
- Sex and Gender in Healthcare
Forschungszentrum Jülich
2016-2024
Institut des Géosciences de l'Environnement
2023
Universitätsklinikum Tübingen
2022
Johannes Gutenberg University Mainz
2014
In modern reproducible, hypothesis-driven plant research, scientists are increasingly relying on research data management (RDM) services and infrastructures to streamline the processes of collecting, processing, sharing, archiving data. FAIR (i.e., findable, accessible, interoperable, reusable) play a pivotal role in enabling integration interdisciplinary knowledge facilitating comparison synthesis wide range analytical findings. The PLANTdataHUB offers solution that realizes RDM scientific...
Abstract Agriculture is confronted with several challenges such as climate change, the loss of biodiversity and stagnating productivity. The massive increasing amount data new digital technologies promise to overcome them, but they necessitate careful integration management make them usable. FAIRagro consortium part National Research Data Infrastructure (NFDI) in Germany will develop FAIR compliant infrastructure services for agrosystems science community, which be integrated existing...
Abstract Background 5-Ketofructose (5-KF) has recently been identified as a promising non-nutritive natural sweetener. Gluconobacter oxydans strains have developed that allow efficient production of 5-KF from fructose by plasmid-based expression the dehydrogenase genes fdhSCL japonicus . As plasmid-free are preferred for industrial food additives, we aimed at construction with chromosomally integrated. Results For production, selected four sites in genome G. IK003.1 and inserted under...
γ-Aminobutyric acid (GABA) is a non-proteinogenic amino mainly formed by decarboxylation of L-glutamate and widespread in nature from microorganisms to plants animals. In this study, we analyzed the regulation GABA utilization Gram-positive soil bacterium Corynebacterium glutamicum, which serves as model system Actinobacteria. We show that usage subject both specific global regulatory mechanisms. Transcriptomics revealed gabTDP genes encoding transaminase, succinate semialdehyde...
The acetic acid bacterium Gluconobacter oxydans 621H is characterized by its exceptional ability to incompletely oxidize a great variety of carbohydrates in the periplasm. metabolism this α-proteobacterium has been some extent, yet little known about transcriptomes and related data. In study, we applied two different RNAseq approaches. Primary enriched for 5′-ends transcripts were sequenced detect transcription start sites, which allow subsequent analysis promoter motifs, ribosome binding...
Gene expression in the obligately aerobic acetic acid bacterium Gluconobacter oxydans responds to oxygen limitation, but regulators involved are unknown. In this study, we analyzed a transcriptional regulator named GoxR (GOX0974), which is only member of fumarate-nitrate reduction (FNR) family species. Evidence that contains an iron-sulfur cluster was obtained, suggesting functions as sensor similar FNR. The direct target genes were determined by combining several approaches, including...
Corynebacterium glutamicum is the major host for industrial production of amino acids and has become one best studied model organisms in microbial biotechnology. Rational strain construction led to an improvement producer strains a variety novel with broad substrate product spectrum. A key factor success these approaches detailed knowledge transcriptional regulation C. glutamicum. Here, we present large compendium 927 manually curated microarray-based profiles wild-type engineered detecting...
The importance of improving the FAIRness (findability, accessibility, interoperability, reusability) research data is undeniable, especially in face large, complex datasets currently being produced by omics technologies. Facilitating integration a dataset with other types increases likelihood reuse, and potential answering novel questions. Ontologies are useful tool for semantically tagging as adding relevant metadata understanding how was its interoperability. provide concepts particular...
Gluconobacter oxydans is a strictly aerobic Gram-negative acetic acid bacterium used industrially for oxidative biotransformations due to its exceptional type of catabolism. It incompletely oxidizes wide variety carbohydrates regio- and stereoselectively in the periplasm using membrane-bound dehydrogenases with accumulation products medium. As consequence, only small fraction carbon energy source enters cell, resulting low biomass yield. Additionally, central metabolism characterized by...
Abstract Research Data Management (RDM) is a system for the effective handling of research data that enables scientists to structure their questions and ensure best practices throughout lifecycle, from acquisition, computation annotation publication re-use. management plans (DMPs) are documents formally set out RDM project required by many funding bodies. DMPs help organize strategies, thus promoting findability, accessibility, interoperability reusability (FAIR). Although incorporate...
The importance of improving the FAIRness (findability, accessibility, interoperability, reusability) research data is undeniable, especially in face large, complex datasets currently being produced by omics technologies. Facilitating integration a dataset with other types increases likelihood reuse, and potential answering novel questions. Ontologies are useful tool for semantically tagging as adding relevant metadata understanding how was its interoperability. provide concepts particular...
Research data management (RDM) combines a set of practices for the organization, storage and preservation from research projects. The RDM strategy project is usually formalized as plan (DMP)—a document that sets out procedures to ensure findability, accessibility, interoperability reusability (FAIR-ness). Many aspects are standardized across disciplines so metadata reusable, but components DMPs in plant sciences often disconnected. inability reuse plant-specific DMP content projects funding...