A5029483496- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Garlic and Onion Studies
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Glycosylation and Glycoproteins Research
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Gut microbiota and health
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Esophageal Cancer Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Histone Deacetylase Inhibitors Research
- Nephrotoxicity and Medicinal Plants
- Chemokine receptors and signaling
- Vascular Anomalies and Treatments
- RNA regulation and disease
- Thyroid and Parathyroid Surgery
- Liver physiology and pathology
- Genomics, phytochemicals, and oxidative stress
- Cancer Cells and Metastasis
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
Capital Medical University
2020-2025
Beijing Chest Hospital
2020-2024
Peking University
2018-2020
Peking University Cancer Hospital
2018-2020
Beijing Jiaotong University
2016-2018
National Cancer Institute
2016-2018
Center for Cancer Research
2016-2018
Frederick National Laboratory for Cancer Research
2016
Abstract Genome-wide analysis of genomic signatures might reveal novel mechanisms for gastric cancer (GC) tumorigenesis. Here, we structural variations (SVs) and mutational via whole-genome sequencing 168 GCs. Our data demonstrates diverse models complex SVs operative in GC, which lead to high-level amplification oncogenes. We find varying proportion tandem-duplications (TDs) among individuals identify 24 TD hotspots involving well-established genes such as CCND1, ERBB2 MYC . Specifically,...
Abstract The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency Fam3D associated with impaired integrity colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production sensitivity chemically induced...
Metallothionein 2A (MT2A) and nuclear factor-kappaB (NF-κB) are both involved in carcinogenesis cancer chemosensitivity. We previously showed decreased expression of MT2A IκB-α human gastric (GC) associated with poor prognosis GC patients. The present study investigated the effect diallyl trisulfide (DATS), a garlic-derived compound, docetaxel (DOC) on regulation relation to NF-κB cells.DATS attenuated signaling cells, resulting G2/M cell cycle arrest apoptosis, culminating inhibition...
Treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has brought significant benefits to non-small cell lung cancer (NSCLC) patients EGFR mutations.However, most eventually develop acquired resistance after treatment.This study investigated the epigenetic effects of mucin 17 (MUC17) in drug-resistant cells EGFR-TKIs.We found that GR/OR (gefitinib/osimertinib-resistance) enhance genome-wide DNA hypermethylation, mainly 5-UTR associated multiple oncogenic...
Abstract Purpose: Metallothionein 2A (MT2A) suppresses the progression of human gastric cancer potentially through an “MT2A–NF-κB pathway” with unclear mechanisms. This study explored role a transcription factor, myeloid zinc-finger 1 (MZF1), in MT2A-NF-κB pathway and its clinical significance cancer. Experimental Design: MZF1 expression function were investigated vitro vivo. The relationship between MT2A was determined by gain-of-function loss-of-function assays cells immortalized cell line...
Abstract Cancer is a highly heterogeneous disease that poses serious threat to human health worldwide. Despite significant advances in the diagnosis and treatment of cancer, prognosis survival rate cancer remain poor due late diagnosis, drug resistance, adverse reactions. Therefore, it very necessary study development mechanism formulate effective therapeutic interventions. As widely available bioactive substances, natural products have shown obvious anticancer potential, especially by...
Introduction Colorectal cancer (CRC) is the third most common cancer. Precise prediction of CRC patients’ overall survival (OS) probability could offer advice on its treatment. Neural network (NN) first-class algorithm, but a consensus which NN models are better has not been established yet. A predictive model using Asian data also lacking. Material and methods We conducted 8 (n = 416) with different theories compared them data. Results DeepSurv performed best C-index value 0.8300 in...
As confusion mounts over RNA isoforms involved in phenotypic plasticity, aberrant CpG methylation-mediated disruption of alternative splicing is increasingly recognized as a driver intratumor heterogeneity (ITH). Protease serine 3 (PRSS3), possessing four splice variants (PRSS3-SVs; PRSS3-V1-V4), an indispensable trypsin that shows paradoxical effects on cancer development. Here, we found PRSS3 transcripts and their were divergently expressed lung cancer, exhibiting opposing functions...
The ATPase H+/K+ Transporting Beta Subunit (ATP4B) encodes the β subunit of gastric H+, K+-ATPase, which controls acid secretion and is therefore a target for reduction. Downregulation ATP4B was recently observed in human cancer (GC) without known mechanisms. In present study, we demonstrated that expression decreased GC tissues cell lines associated with DNA hypermethylation histone hypoacetylation H3 lysine 9 at its intragenic region close to transcriptional start site. restored by...
Disruption in mucins (MUCs) is involved cancer development and metastasis thus used as a biomarker. Non‑small cell lung carcinoma (NSCLC) characterized by heterogeneous genetic epigenetic alterations. Lung adenocarcinoma (LUAD) squamous (LUSC) are the two primary subtypes of NSCLC that require different therapeutic interventions. Here, we report distinct expression alterations mucin 22 (<em>MUC22</em>), new MUC family member, LUSC vs. LUAD. In lines tissues, <em>MUC22</em> was downregulated...
Background: Brain metastasis (BM) represents one of the most common advanced disease states in breast cancer (BC), especially human epidermal growth factor receptor 2 (HER2)-positive BC, and is associated with poor survival outcomes. Methods: In this study, in-depth analysis microarray data from GSE43837 dataset 19 BM samples HER2-positive BC patients nonmetastatic primary was conducted. The differentially expressed genes (DEGs) between were identified function enrichment DEGs conducted to...
Background Hepatocellular carcinoma (HCC) is one of the most lethal human tumors with extensive intratumor heterogeneity (ITH). Serine protease 3 (PRSS3) an indispensable member trypsin family and has been implicated in pathogenesis several malignancies, including HCC. However, paradoxical effects PRSS3 on carcinogenesis due to unclear molecular basis impede utilization its biomarker potential. We hereby explored contribution transcripts tumor functional by systematically dissecting...
Surgery is the main treatment option for destroyed-lung (DL) patients with life-threatening massive hemoptysis. However, short-term and long-term surgical safety efficacy are unclear, prompting this study. Data from 124 DL undergoing surgery between November 2001 January 2022 at Beijing Chest Hospital were retrospectively analyzed. of group (82 cases) + hemoptysis (42 compared regard to clinical characteristics, postoperative residual lung reinfection. As rates, The had greater incidence...
IntroductionIn clinical practice, some patients undergoing surgery for thymoma require post-surgical ventilator support, although, factors associated with administration of support are unclear. This study aimed to explore incidence severe respiratory failure requiring after resection.MethodsClinical data who underwent re-section in our thoracic department between January 2001 and February 2020 was retrospectively analyzed. Multiple logistic regression analysis used identify patient need...