A5034121428- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmaceutical and Antibiotic Environmental Impacts
- Cholinesterase and Neurodegenerative Diseases
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Computational Drug Discovery Methods
- Water Treatment and Disinfection
- Antibiotic Resistance in Bacteria
- Clostridium difficile and Clostridium perfringens research
- HIV Research and Treatment
- Effects of Radiation Exposure
- Coal and Its By-products
- Plant tissue culture and regeneration
- Plant-derived Lignans Synthesis and Bioactivity
- Herpesvirus Infections and Treatments
- Identification and Quantification in Food
- Microbial infections and disease research
- Genomics, phytochemicals, and oxidative stress
- Biosensors and Analytical Detection
- Animal Virus Infections Studies
- Histone Deacetylase Inhibitors Research
- Viral Infections and Immunology Research
- Prion Diseases and Protein Misfolding
Beijing Academy of Science and Technology
2023-2025
Beijing Chest Hospital
2023
Capital Medical University
2023
Beijing Jiaotong University
2014-2021
Feinstein Institute for Medical Research
2020
Beijing Fengtai Hospital
2016
Abstract Background We have proved fecal microbiota transplantation (FMT) is an efficacious remedy to mitigate acute radiation syndrome (ARS); however, the mechanisms remain incompletely characterized. Here, we aimed tease apart gut microbiota-produced metabolites, underpin therapeutic effects of FMT injuries, and elucidate underlying molecular mechanisms. Results elevated level microbial-derived indole 3-propionic acid (IPA) in pellets from irradiated mice. IPA replenishment via oral route...
Treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has brought significant benefits to non-small cell lung cancer (NSCLC) patients EGFR mutations.However, most eventually develop acquired resistance after treatment.This study investigated the epigenetic effects of mucin 17 (MUC17) in drug-resistant cells EGFR-TKIs.We found that GR/OR (gefitinib/osimertinib-resistance) enhance genome-wide DNA hypermethylation, mainly 5-UTR associated multiple oncogenic...
Abstract Cancer is a highly heterogeneous disease that poses serious threat to human health worldwide. Despite significant advances in the diagnosis and treatment of cancer, prognosis survival rate cancer remain poor due late diagnosis, drug resistance, adverse reactions. Therefore, it very necessary study development mechanism formulate effective therapeutic interventions. As widely available bioactive substances, natural products have shown obvious anticancer potential, especially by...
Active immunotherapy targeting β-amyloid (Aβ) is the most promising strategy to prevent or treat Alzheimer's disease (AD). Based on pre-clinical studies and clinical trials, a safe effective AD vaccine requires delicate balance between providing therapeutically adequate anti-Aβ antibodies eliminating suppressing unwanted adverse T cell-mediated inflammatory reactions. We describe here immunological characterization protective efficacy of co-immunization with 6Aβ15-T DNA protein mixture...
The United Nations proposed the Sustainable Development Goals with aim to make human settlements in cities resilient and sustainable. excessive discharge of urban waste including sludge garden can pollute groundwater lead emission greenhouse gases (e.g., CH4). proper recycling is essential for responsible consumption production, reducing environmental pollution addressing climate change issues. This study aimed prepare biochar high adsorption amounts iodine using peach wood from waste. was...
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder that impairs memory and cognition. Targeting amyloid-β (Aβ) may be currently the most promising immunotherapeutic strategy for AD. In this study, recombinant chimeric 6Aβ15-THc-C immunogen was formulated with alum adjuvant as novel Aβ B-cell epitope candidate vaccine (rCV02) We examined its efficacy in preventing cognitive deficit synaptic impairment 3 × Tg-AD mice. Using toxin-derived carrier protein, rCV02 elicited robust...
Background: Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder characterized by senile plaques and neurofibrillary tangles (NFTs). The amyloid-oligomer hypothesis indicates that buildup of toxic oligomers in vivo likely to impair memory synaptic function. Methods: In our study, a kind novel recombinant chimeric 12×(Aβ1-15-Th) antigen was developed as 12-mer Aβ1-42-like assembly vaccine. We designed this 12×(Aβ1-15- Th) mimic states Aβ1-42 using twelvefold...