A5080419561- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Fungal Infections and Studies
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Nail Diseases and Treatments
- Cancer Immunotherapy and Biomarkers
- Toxin Mechanisms and Immunotoxins
- Tumors and Oncological Cases
- Histiocytic Disorders and Treatments
- Acute Lymphoblastic Leukemia research
- Viral-associated cancers and disorders
- NF-κB Signaling Pathways
LEO Foundation
2019-2020
University of Copenhagen
2016-2020
Zhengzhou University
2013-2014
First Affiliated Hospital of Zhengzhou University
2014
// Lise M. Lindahl 1 , Simon Fredholm 2 Claudine Joseph Boye Schnack Nielsen 3 Lars Jønson 4 Andreas Willerslev-Olsen Maria Gluud Edda Blümel David L. Petersen Nina Sibbesen Tengpeng Hu Claudia Nastasi Thorbjørn Krejsgaard Ditte Jæhger Jenny Persson 5 Nigel Mongan 6 Mariusz A. Wasik 7 Ivan V. Litvinov 8 Denis Sasseville 9 Sergei B. Koralov 10 Charlotte Bonefeld Carsten Geisler Anders Woetmann Elisabeth Ralfkiaer 11 Iversen Niels Odum Department of Dermatology, Aarhus...
Extranodal natural killer/T-cell lymphoma (ENKL) is marked by a profound cellular immune deficiency that may influence the capacity of T cells to extract an efficient antitumor response. It has been confirmed B7-CD28 pathway promote tumor evasion providing negative regulatory signal. The current study analyzed expression programmed death 1 (PD-1)/programmed ligand (PD-L) in ENKL cell lines and tissues. functional studies were performed analyze activity PD-L1 interacting with effective ENKL....
Staphylococcus aureus is implicated in disease progression cutaneous T-cell lymphoma (CTCL). Here, we demonstrate that malignant T cell lines derived from CTCL patients as well primary CD4+ cells Sézary syndrome are considerably more resistant to alpha-toxin-induced death than their non-malignant counterparts. Thus, a subset of the ratio between and increases significantly following exposure alpha-toxin. Whereas toxin-induced ADAM10 dependent healthy cells, resistance alpha-toxin involves...
Staphylococcus aureus and its toxins have been linked to disease progression mortality in advanced stages of cutaneous T-cell lymphoma (CTCL). CD8+ T cells play a crucial role anti-cancer responses high cell numbers tumor lesions are associated with favorable prognosis CTCL. Here, we show that from both healthy donors Sézary syndrome patients highly susceptible death induced by Staphylococcal alpha-toxin, whereas malignant not. Importantly, alpha-toxin almost completely blocks cytotoxic...
Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm arising most commonly from follicular cells in the lymph nodes. It exceedingly extranodal sites, particularly pharyngeal region. The present study reports 3 cases occurring Case 1 had tonsil and cervical node involvement, while case also involvement. Cases relapsed locally at 17 months after surgery, respectively. 2 was diagnosed with tumor parapharyngeal space patient succumbed to disease 5 treatment combined surgery chemotherapy....
The thioredoxin-interacting protein (TXNIP) is involved in cellular metabolism and cell proliferation, recently, deficient expression of TXNIP has been associated with progression poor outcome for cancer patients.To assess function malignant T cells from cutaneous T-cell lymphoma (CTCL).CTCL-derived (MyLa2059, PB2B) non-malignant (MyLa1850) lines were analysed by Western blotting qPCR expression. Subsequently, the CTCL treated GSK126 - an inhibitor enhancer zeste homolog 2 (EZH2)...
A prognostic 3-miRNA classifier for early-stage mycosis fungoides has been developed recently, with miR-106b providing the strongest power. The aim of this study was to investigate molecular function in disease progression. cellular localization skin biopsies determined by situ hybridization. regulatory role assessed transient inhibitor/mimic transfection 2 derived cell lines, followed quantitative real-time PCR (RT-qPCR), western blotting and a proliferation assay. MiR-106b found be...
The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed by a subset of chronically activated memory T cells and plays an important role in their activation proliferation. Here, we show that primary malignant isolated from patients with Sézary syndrome (SS) express are sensitive to potent inhibitors ShK Vm24, but not less inhibitor [N17A/F32T]-AnTx. blockade inhibits CD3/CD28-induced proliferation IL-9 expression SS concentration-dependent manner. In parallel, CD3/CD28-mediated CD25...
<b><i>Background:</i></b> The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed by effector memory T cells (T<sub>EM</sub>) and plays an important role in their activation proliferation. Mycosis fungoides (MF), the most common subtype of cutaneous T-cell lymphoma (CTCL), was recently proposed to be a malignancy skin-resident T<sub>EM</sub>. However, expression CTCL has not been investigated....