A5010381383- Cutaneous lymphoproliferative disorders research
- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- Biotin and Related Studies
- Fungal Infections and Studies
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- NF-κB Signaling Pathways
University of Copenhagen
2019-2020
LEO Foundation
2019-2020
The thioredoxin-interacting protein (TXNIP) is involved in cellular metabolism and cell proliferation, recently, deficient expression of TXNIP has been associated with progression poor outcome for cancer patients.To assess function malignant T cells from cutaneous T-cell lymphoma (CTCL).CTCL-derived (MyLa2059, PB2B) non-malignant (MyLa1850) lines were analysed by Western blotting qPCR expression. Subsequently, the CTCL treated GSK126 - an inhibitor enhancer zeste homolog 2 (EZH2)...
A prognostic 3-miRNA classifier for early-stage mycosis fungoides has been developed recently, with miR-106b providing the strongest power. The aim of this study was to investigate molecular function in disease progression. cellular localization skin biopsies determined by situ hybridization. regulatory role assessed transient inhibitor/mimic transfection 2 derived cell lines, followed quantitative real-time PCR (RT-qPCR), western blotting and a proliferation assay. MiR-106b found be...
The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed by a subset of chronically activated memory T cells and plays an important role in their activation proliferation. Here, we show that primary malignant isolated from patients with Sézary syndrome (SS) express are sensitive to potent inhibitors ShK Vm24, but not less inhibitor [N17A/F32T]-AnTx. blockade inhibits CD3/CD28-induced proliferation IL-9 expression SS concentration-dependent manner. In parallel, CD3/CD28-mediated CD25...