A5082493583- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Neurotransmitter Receptor Influence on Behavior
- Genetics and Neurodevelopmental Disorders
- Adenosine and Purinergic Signaling
- Sleep and Wakefulness Research
- Genomics, phytochemicals, and oxidative stress
- Bipolar Disorder and Treatment
- Peroxisome Proliferator-Activated Receptors
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Nicotinic Acetylcholine Receptors Study
- Olfactory and Sensory Function Studies
- Adipose Tissue and Metabolism
- Pain Mechanisms and Treatments
- Resilience and Mental Health
- Molecular Communication and Nanonetworks
- Seaweed-derived Bioactive Compounds
- Vagus Nerve Stimulation Research
- Cancer-related gene regulation
- Neuroinflammation and Neurodegeneration Mechanisms
Jinan University
2020-2024
Southern Medical University
2013-2023
Nanfang Hospital
2023
Guangzhou Medical University
2023
Luoyang Orthopedic-Traumatological Hospital of Henan Province
2018
Abstract The transcription factor erythroid 2-related 2 (Nrf2) and brain-derived neurotrophic (BDNF) play a key role in depression. However, the molecular mechanisms underlying crosstalk between Nrf2 BDNF depression remain unclear. We examined whether regulates of Bdnf by binding to its exon I promoter. Furthermore, brain regions from mice with depression-like phenotypes was examined. regulated Activation sulforaphane (SFN) showed fast-acting antidepressant-like effects activating as well...
Mounting evidence suggests the key role of brain-derived neurotrophic factor (BDNF) in dopaminergic neurotoxicity Parkinson's disease (PD). Activation NF-E2-related factor-2 (Nrf2) and inhibition methyl CpG-binding protein 2 (MeCP2) can regulate BDNF upregulation. However, regulation by Nrf2 MeCP2 PD pathogenesis has not been reported. Here, we revealed that Nrf2/MeCP2 coordinately regulated transcription, reversing decreased levels expression 1-methyl-4-phenylpyridinium (MPP+)-treated...
<title>Abstract</title> In addition to its well-established role in vision, environmental light also plays a crucial non-image-forming visual functions, including the regulation of instinctive behaviors such as feeding. Clinical evidence suggests that bright therapy can alleviate symptoms individuals with obesity. However, neural mechanisms underlying influence on feeding remain poorly understood. this study, we demonstrate treatment effectively reduces food intake and mitigates weight gain...
Social isolation during the vulnerable period of adolescence produces emotional dysregulation that often manifests as abnormal behavior in adulthood. The enduring consequence might be caused by a weakened ability to forget unpleasant memories. However, it remains unclear whether affects To address this, we used model associative learning induce fear memories and evaluated influence mice on subsequent retention its underlying cellular mechanisms. Following adolescent social isolation, found...
Previous studies have shown that Lycium barbarum polysaccharide, the main active component of barbarum, exhibits anti-inflammatory and antioxidant effects in treating neurological diseases. However, therapeutic action polysaccharide on depression has not been studied. In this investigation, we established mouse models using aversive stimuli including exposure to fox urine, air puff foot shock physical restraint. Concurrently, administered 5 mg/kg per day polysaccharide-glycoprotein each...
Light in the environment greatly impacts a variety of brain functions, including sleep. Clinical evidence suggests that bright light treatment has beneficial effect on stress–related diseases. Although stress can alter sleep patterns, stress–induced alterations and underlying mechanism are poorly understood. Here, we show reduces increase nonrapid eye movement (NREM) induced by chronic through di–synaptic visual circuit consisting thalamic ventral lateral geniculate nucleus intergeniculate...
Abstract Research highlights the significance of increased bursting in lateral habenula (LHb) neurons depression and as a focal point for bright light treatment (BLT). However, precise spike patterns LHb projecting to different brain regions during depression, their roles development, BLT's therapeutic action remain elusive. Here, are found dorsal raphe nucleus (DRN), ventral tegmental area (VTA), median (MnR) exhibit following aversive stimuli exposure, correlating with distinct depressive...
Many psychiatric diseases such as post-traumatic stress disorder (PTSD) are characterized by abnormal processing of emotional stimuli particularly fear. The medial prefrontal cortex (mPFC) is critically involved in fear expression. However, the molecular mechanisms underlying this process largely unknown. Neuregulin-1 (NRG1) reportedly regulates pyramidal neuronal activity via ErbB4 receptors, which abundant parvalbumin (PV)-expressing interneurons PFC. In study, we aimed to determine how...
Growing evidence for the importance of gut-brain axis in Parkinson's disease (PD) has attracted researchers' interest possible application microbiota-based treatment approaches. Using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model, we looked into prospect treating PD with fucosylated chondroitin sulfate obtained from sea cucumbers Isostichopus badionotus (fCS-Ib). We showed that giving fCS-Ib polysaccharide orally greatly reduced motor deficits, dopamine depletion,...
Depression is a prevalent psychiatric disorder with accumulating evidence implicating dysregulation of extracellular adenosine triphosphate (ATP) levels in the medial prefrontal cortex (mPFC). It remains unclear whether facilitating endogenous ATP production and subsequently increasing level mPFC can exert prophylactic effect against chronic social defeat stress (CSDS)-induced depressive-like behaviors enhance resilience. Here, we found that nicotinamide mononucleotide (NMN) treatment...
In addition to its role in vision, light also serves non-image-forming visual functions. Despite clinical evidence suggesting the antipruritic effects of bright treatment, circuit mechanisms underlying on itch-related behaviors remain poorly understood. this study, we demonstrate that treatment reduces mice through a related lateral parabrachial nucleus (LPBN). Specifically, subset retinal ganglion cells (RGCs) innervates GABAergic neurons ventral geniculate and intergeniculate leaflet...