A5100353663- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Inflammasome and immune disorders
- Helicobacter pylori-related gastroenterology studies
- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Mesenchymal stem cell research
- Inflammatory Bowel Disease
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
- Liver physiology and pathology
- Pneumonia and Respiratory Infections
- Chronic Lymphocytic Leukemia Research
Guangdong Academy of Medical Sciences
2016-2025
Guangdong General Hospital
2013-2025
Wenzhou Medical University
2019-2025
University of Science and Technology of China
2023-2025
Southern Medical University
2011-2025
Guangdong Provincial People's Hospital
2020-2025
Nanjing University of Chinese Medicine
2021-2025
Shantou University
2022-2025
Shantou University Medical College
2022-2025
South China University of Technology
2016-2025
The incidence of ulcerative colitis (UC) is on the rise globally and development drugs targeting UC urgent. Finding target action natural products important for drug discovery, elucidation mechanism, disease mechanism. San-Ye-Qing (SYQ), an ancient herbal medicine, but whether powder its rhizome has pharmacological effects against mechanism are not clear.
We developed and evaluated seven interfaces for integrating semantic category information with Web search results. List were based on the familiar ranked-listing of results, sometimes augmented a name each result. Category also showed page titles and/or names, but re-organized results so that items in same grouped together visually. Our user studies show all more effective than even when lists names The best performance was obtained both individual presented. Either alone is better list...
Mitochondria need to be fragmented prior engulfment by phagophores, the precursors autophagosomes. However, how these 2 processes are finely regulated and integrated is poorly understood. We have shown that outer mitochondrial membrane protein FUNDC1 a novel mitochondrial-associated (MAM) protein, enriched at MAM interacting with ER resident CANX (calnexin) under hypoxia. As mitophagy proceeds, it dissociates from preferably recruits DNM1L/DRP1 drive fission in response hypoxic stress. In...
The periosteum, a thin tissue that covers almost the entire bone surface, accounts for more than 80% of human mass and is essential regeneration. Its osteogenic regenerative abilities are well studied, but much unknown about periosteum. In this study, we found macrophage-lineage cells recruit periosteum-derived (PDCs) cortical formation. Knockout colony stimulating factor-1 eliminated resulted in loss PDCs with impaired periosteal Moreover, TRAP+ induced transcriptional expression periostin...
Process intensification in biomanufacturing has attracted a great deal of interest recent years. Manufacturing platform improvements leading to higher cell density and bioreactor productivity have been pursued. Here we evaluated variety intensified mammalian culture processes for producing monoclonal antibodies. Cell operational modes including fed-batch (normal seeding or high with N-1 perfusion), perfusion, concentrated (CFB) were assessed using the same media set Chinese Hamster Ovary...
Abstract Conditioned medium from mesenchymal stem cells (MSC-CM) may represent a promising alternative to MSCs transplantation, however, the low concentrations of growth factors in non-activated MSC-CM hamper its clinical application. Recent data indicated that paracrine potential could be enhanced by inflammatory factors. Herein, we pre-activated bone-marrow-derived under radiation-induced condition (MSC IEC-6(IR) ) and investigated evidence mechanism for differential effects on intestinal...
Insulinomas and non-functional pancreatic neuroendocrine tumours (NF-PanNETs) have distinctive clinical presentations but share similar pathological features. Their genetic bases not been comprehensively compared. Herein, we used whole-genome/whole-exome sequencing (WGS/WES) to identify differences between insulinomas NF-PanNETs.The mutational profiles copy-number variation (CNV) patterns of 211 PanNETs, including 84 127 NF-PanNETs, were obtained from WGS/WES data provided by Peking Union...
Abstract Sepsis is a systemic inflammatory response syndrome caused by infection, resulting in organ dysfunction. Sepsis‐induced acute kidney injury (AKI) one of the most common potential complications. Increasing reports have shown that M1 and M2 macrophages both take part progress AKI influencing level factors cell death, including pyroptosis. However, whether regulate secreting exosome remains unknown. In present study, we isolated exosomes from used Western blot enzyme‐linked...
Abstract Recent advances in environmental genomics have provided unprecedented opportunities for the investigation of viruses natural settings. Yet, our knowledge viral biogeographic patterns and corresponding drivers is still limited. Here, we perform metagenomic deep sequencing on 90 acid mine drainage (AMD) sediments sampled across Southern China examine biogeography this extreme environment. The results demonstrate that prokaryotic communities dictate taxonomic functional diversity,...
Pancreatic cancer (PC) is a highly lethal malignancy that requires effective novel therapies. M2 macrophages are abundant in the PC microenvironment and promote progression. Exosomes emerging mediators of crosstalk between cells microenvironment. This study was conducted to explore role macrophage-derived exosomes PC.Exosomes derived from were extracted. miR-193b-3p TRIM62 overexpressed or silenced examine their function PC. Luminescence assays used investigate interaction TRIM62. Cell...
Observational studies have indicated associations between inflammatory bowel disease (IBD) and neurodegenerative diseases, including Parkinson's (PD).To evaluate the causal of IBD with PD other selected disorders using updated data.Bidirectional two-sample Mendelian randomization genome-wide association summary statistics PD.We found a lack evidence for on (odds ratio [OR], 1.014; 95% confidence interval [CI], 0.967-1.063; P = 0.573). Reverse analysis also no effect (OR, 0.978; CI,...
Abstract Background In the post-pandemic era, a wide range of COVID-19 sequelae is growing health concern. However, risks digestive diseases in long COVID have not been comprehensively understood. To investigate long-term risk among patients. Methods this large-scale retrospective cohort study with up to 2.6 years follow-up (median follow-up: 0.7 years), group ( n = 112,311), contemporary comparison 359,671) and historical 370,979) predated outbreak were built using UK Biobank database. Each...
As a major cellular defence mechanism, the Nrf2/Keap1 pathway regulates expression of genes involved in detoxification and stress response. Here we hypothesise that Nrf2 is oesophageal barrier function plays protective role against gastro-oesophageal reflux disease (GERD).Human biopsy samples, mouse surgical models Nrf2(-/-) mice were used to assess function. Trans-epithelial electrical resistance (TEER) was measured with mini-Ussing chambers. HE staining transmission electron microscopy...
Metastasis and recurrence are the challenges of cancer therapy. Recently, mounting evidence has suggested that stem cells (CSCs) epithelial-mesenchymal transition (EMT) critical factors in tumor metastasis recurrence. The oncogene, Bmi-1, promotes development hematologic malignancies many solid tumors. aim present study was to elucidate mechanisms through which Bmi-1 invasion migration colon CSCs (CCSCs) using HCT116 cell line. Sphere formation medium magnetic‑activated sorting were used...
Despite the unprecedented advancement of cancer treatment, prognosis for patients with metastatic stage remains poor. The challenge that underlines this clinical dilemma is complexity metastasis. conventional experiment-driven discovery approaches (the “wet lab”) yield overly simplified one-to-one mechanistic relationships are inept elucidating Metastasis research also suffers from knowledge and skill deficiency individual investigators. importance present study demonstration “dry-lab-driven...