Siliang Li
A5101924822- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Evolution and Genetic Dynamics
- Genomics and Phylogenetic Studies
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Cancer-related molecular mechanisms research
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Genetics, Bioinformatics, and Biomedical Research
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- Genomics and Rare Diseases
- Pancreatic and Hepatic Oncology Research
- Fuel Cells and Related Materials
- Nanopore and Nanochannel Transport Studies
- Lung Cancer Treatments and Mutations
- DNA Repair Mechanisms
- Telomeres, Telomerase, and Senescence
- Cancer, Hypoxia, and Metabolism
- Genomic variations and chromosomal abnormalities
- Mitochondrial Function and Pathology
- Gene expression and cancer classification
- Vehicle emissions and performance
BGI Group (China)
2012-2023
China National GeneBank
2017-2022
Lunenfeld-Tanenbaum Research Institute
2021
Sinai Health System
2021
University of Copenhagen
2020
University of Chicago
2020
The University of Texas MD Anderson Cancer Center
2020
Institute of Cancer Research
2020
Changchun University of Technology
2018
Abstract Transcript alterations often result from somatic changes in cancer genomes 1 . Various forms of RNA have been described cancer, including overexpression 2 , altered splicing 3 and gene fusions 4 ; however, it is difficult to attribute these underlying genomic owing heterogeneity among patients tumour types, the relatively small cohorts for whom samples analysed by both transcriptome whole-genome sequencing. Here we present, our knowledge, most comprehensive catalogue...
Insulinomas and non-functional pancreatic neuroendocrine tumours (NF-PanNETs) have distinctive clinical presentations but share similar pathological features. Their genetic bases not been comprehensively compared. Herein, we used whole-genome/whole-exome sequencing (WGS/WES) to identify differences between insulinomas NF-PanNETs.The mutational profiles copy-number variation (CNV) patterns of 211 PanNETs, including 84 127 NF-PanNETs, were obtained from WGS/WES data provided by Peking Union...
A simple and efficient strategy to generate human trophoblast stem cells is reported aid investigations of early placentation.
Abstract The impact of somatic structural variants (SVs) on gene expression in cancer is largely unknown. Here, as part the ICGC/TCGA Pan-Cancer Analysis Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA from a common set 1220 cases, we report hundreds genes for presence within 100 kb an SV breakpoint associates with altered expression. For majority these genes, increases rather than decreases corresponding events. Up-regulated cancer-associated impacted...
Abstract We present the most comprehensive catalogue of cancer-associated gene alterations through characterization tumor transcriptomes from 1,188 donors Pan-Cancer Analysis Whole Genomes project. Using matched whole-genome sequencing data, we attributed RNA to germline and somatic DNA alterations, revealing likely genetic mechanisms. identified 444 associations expression with non-coding single-nucleotide variants. found 1,872 splicing associated mutation in intronic regions, including...
Abstract Introduction: We present a novel method to identify cancer driver genes that jointly examines any number of diverse transcriptomic alterations with the goal uncover highly recurrent and heterogeneous patterns in 1190 samples across 26 types as part PanCancer Analysis Whole Genomes (PCAWG) International Cancer Genome Consortium (ICGC). Motivation: Previous pan-cancer genomic studies have focused on analysis somatic mutations phenotypic changes. Here, we propose integrate wide variety...