A5030654265- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Porphyrin and Phthalocyanine Chemistry
- Immunotherapy and Immune Responses
- Advanced biosensing and bioanalysis techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Circular RNAs in diseases
- Advanced Nanomaterials in Catalysis
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Wheat and Barley Genetics and Pathology
- Gold and Silver Nanoparticles Synthesis and Applications
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
Peking University
2016-2025
Peking University Third Hospital
2016-2025
Dalian University
2024-2025
Dalian University of Technology
2024-2025
Chinese Academy of Sciences
2015-2024
Huazhong Agricultural University
2020-2024
China Agricultural University
2024
Air Force Engineering University
2022-2024
Guangzhou Medical University
2024
First Affiliated Hospital of Soochow University
2024
Abstract A novel multifunctional drug‐delivery platform is developed based on cholesteryl succinyl silane (CSS) nanomicelles loaded with doxorubicin, Fe 3 O 4 magnetic nanoparticles, and gold nanoshells (CDF‐Au‐shell nanomicelles) to combine resonance (MR) imaging, magnetic‐targeted drug delivery, light‐triggered release, photothermal therapy. The show improved drug‐encapsulation efficiency loading level, a good response fields, even after the formation of nanoshell. An enhancement for T 2...
Polypyrrole nanoparticles conjugating gadolinium chelates were successfully fabricated for dual‐modal magnetic resonance imaging (MRI) and photoacoustic guided photothermal therapy of cancer, from a mixture pyrrole pyrrole‐1‐propanoic acid through facile one‐step aqueous dispersion polymerization, followed by covalent attachment chelate, using polyethylene glycol as linker. The obtained PEGylated polypyrrole (Gd‐PEG‐PPy NPs), sized around 70 nm, exhibited high T 1 relaxivity coefficient...
Photodynamic therapy (PDT) shows great promise for the treatment of colon cancer. However, practically, it is a challenge to use nanocarrier codelivery both photosensitizer and oxygen improve PDT against PDT-induced hypoxia, which closely related tumor metastasis. Hence, an effective strategy was proposed develop self-supplemented based on ultrasonic dispersion perfluorooctyl bromide (PFOB) liquid into preformed porphyrin grafted lipid (PGL) nanoparticles (NPs) with high loading content...
Hepatocellular carcinoma (HCC) is a common and highly malignant tumor that prone to recurrence metastasis has no effective treatment. Unsurprisingly, its prognosis quite poor; early detection methods low-toxicity treatments are urgently needed. To achieve these goals, we designed multifunctional, U.S. Food Drug Administration-approved Prussian blue (PB) nanoparticle (NP) with porous metal organic frame loaded sorafenib (SF), conjugated HCC-specific targeting peptide SP94 the near-infrared...
Hypoxia in a solid tumor microenvironment (TME) can lead to the overexpression of hypoxia-inducible factor-1α (HIF-1α), which correlates metastasis. Reactive oxygen species (ROS) induced cell apoptosis is becoming promising method treatment. Currently, ROS generating systems, e.g., photodynamic treatment and sonodynamic treatment, highly depend on (O2) (TME). However, level O2 TME too low produce enough ROS. Herein, we developed an ultrasmall DSPE-PEG2000 coated barium titanate nanoparticle...
Nanomaterials that combine multimodality imaging and therapeutic functions within a single nanoplatform have drawn extensive attention for molecular medicines biological applications. Herein, we report theranostic based on relatively smaller (<20 nm) iron oxide loaded porphyrin-grafted lipid nanoparticles (Fe3O4@PGL NPs). The amphiphilic PGL easily self-assembled the hydrophobic exterior surface of ultrasmall Fe3O4 NPs, resulting in final Fe3O4@PGL NPs with diameter ∼10 nm. excellent...
Abstract Micro-nano biorobots based on bacteria have demonstrated great potential for tumor diagnosis and treatment. The bacterial gene expression drug release should be spatiotemporally controlled to avoid in healthy tissues undesired toxicity. Herein, we describe an alternating magnetic field-manipulated tumor-homing developed by genetically modifying engineered Escherichia coli with Fe 3 O 4 @lipid nanocomposites. After accumulating orthotopic colon tumors female mice, the paramagnetic...
Nitric oxide (NO) is drawing widespread attention in treating pancreatic ductal adenocarcinoma (PDAC) as a safe and therapeutically efficient technique through modulating the dense fibrotic stroma tumor microenvironment to enhance drug penetration. Considerable NO nanogenerators releasing molecules have been developed shield systemic toxicity caused by free diffusion of gas. However, on-demand controlled release chemotherapy drugs at sites remains problem limited complex dynamic...
Tumor immunotherapy based on immune checkpoint blockade (ICB) still suffers from low host response rate and non-specific distribution of inhibitors, greatly compromising the therapeutic efficiency. Herein, cellular membrane stably expressing matrix metallopeptidase 2 (MMP2)-activated PD-L1 blockades is engineered to coat ultrasmall barium titanate (BTO) nanoparticle for overcoming immunosuppressive microenvironment tumors. The resulting M@BTO NPs can significantly promote BTO's tumor...
Immune checkpoint blockade (ICB) therapy still suffers from insufficient immune response and adverse effect of ICB antibodies. Chemodynamic (CDT) has been demonstrated to be an effective way synergize with therapy. However, a low generation rate reactive oxygen species poor tumor penetration CDT platforms decline the effects. Herein, charge-reversal nanohybrid Met@BF containing both Fe3O4 BaTiO3 nanoparticles in core Metformin (Met) on surface was fabricated for microenvironment (TME)-...
Rationale:Treatment for Parkinson's disease (PD) is challenged by the presence of blood-brain barrier (BBB) that significantly limits effective drug concentration in a patient's brain therapeutic response throughout various stages PD.Curcumin holds potential α-synuclein clearance to treat PD; however, its applications are still limited due low bioavailability and poor permeability through BBB free form.Methods: Herein, this paper fabricated curcumin-loaded polysorbate 80-modified cerasome...
Shining light on cancer cells: A cerasomal photosensitizer of high stability and loading efficiency was developed by conjugation a porphyrin molecule to an organoalkoxysilylated lipid followed sol–gel self-assembly processes (see picture). This nanoformulation showed intrinsic fluorescence significant damage tumor cells under photoirradiation.
The combination of camptothecin (CPT) and fluoropyrimidine derivatives acts synergistically at a 1:1 molar ratio. Practically, the greatest challenge is development single liposomal formulation that can both encapsulate maintain this drug an exact ratio to achieve coordinated pharmacokinetics. Consequently, new type liposome-like nanocapsule (NC) developed from highly symmetric Janus camptothecin-floxuridine conjugate (JCFC) amphiphile, which synthesized by coupling two hydrophobic CPT...
Multidrug resistance remains one of the main obstacles to efficient chemotherapy colorectal cancer. Herein, an combination therapeutic strategy is proposed based on porphyrin/camptothecin-floxuridine triad microbubbles (PCF-MBs) with high drug loading contents, which own highly stable co-delivery combinations and no premature release. The PCF-MBs can act not only as a contrast agent for ultrasound (US)/fluorescence bimodal imaging but also multimodal synergistic chemo-photodynamic therapy....
The high intensity focused ultrasound (HIFU) and thermosensitive cerasomes (HTSCs) were successfully assembled by employing cerasome-forming lipid (CFL) in combination with the component lipids of conventional low temperature sensitive liposomes (LTSLs) including 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG-2000) 1-stearoyl-2-hydroxy-sn-glycero-3-phosphocholine (MSPC). HTSCs showed...
This paper reported a core–shell nanotheranostic agent by growing Prussian blue (PB) nanoshells of 3–6 nm around superparamagnetic Fe3O4 nanocores for targeted photothermal therapy cancer under magnetic resonance imaging (MRI) guidance. Both in vitro and vivo experiments proved that the Fe3O4@PB nanoparticles showed significant contrast enhancement T2-weighted MRI with relaxivity value 58.9 mM–1·s–1. Simultaneously, composite exhibited high effect irradiation near-infrared laser due to...
Breast cancer is characterized by high aggression, poor prognosis, and recurrence rate. Early detection specific targeted treatment with less toxicity are the ultimate goals for breast therapy. To improve antitumor therapeutic effects, we developed a novel polypyrrole nanoparticle using near infrared dye IRDye800CW camptothecin (CPT)-conjugated hyaluronic acid (HA) shell (PPy@CPT-HA-IRDye800CW) performed photothermal therapy (PTT), along chemotherapy, guided fluorescence photoacoustic...
Prussian blue nanoparticles were explored for the first time as an excellent contrast agent enhancing photoacoustic tomography in vitro and vivo due to their superior absorption efficiency of near-infrared laser pulses at a wavelength 765 nm.
Insulinomas and non-functional pancreatic neuroendocrine tumours (NF-PanNETs) have distinctive clinical presentations but share similar pathological features. Their genetic bases not been comprehensively compared. Herein, we used whole-genome/whole-exome sequencing (WGS/WES) to identify differences between insulinomas NF-PanNETs.The mutational profiles copy-number variation (CNV) patterns of 211 PanNETs, including 84 127 NF-PanNETs, were obtained from WGS/WES data provided by Peking Union...