A5100338729- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Luminescence and Fluorescent Materials
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Coastal and Marine Dynamics
- Gold and Silver Nanoparticles Synthesis and Applications
- Geology and Paleoclimatology Research
- Methane Hydrates and Related Phenomena
- MicroRNA in disease regulation
- Aeolian processes and effects
- Geological formations and processes
- Coastal wetland ecosystem dynamics
- Cancer Research and Treatments
- Skin Protection and Aging
- Respiratory Support and Mechanisms
- Ultrasound and Cavitation Phenomena
- Adaptive optics and wavefront sensing
- Genital Health and Disease
Third Affiliated Hospital of Southern Medical University
2020-2024
Xuzhou Medical College
2024
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
Ruijin Hospital
2024
Chinese PLA General Hospital
2024
Chinese People's Liberation Army
2024
Peking University Third Hospital
2019-2023
Peking University
2019-2023
University of Minnesota
2019-2023
Abstract: The fabrication and initial applications of nanobubbles (NBs) have shown promising results in recent years. A small particle size is a basic requirement for ultrasound contrast-enhanced agents that penetrate tumor blood vessel pores to allow targeted imaging therapy. However, the nanoscale particles used has disadvantage weakening ability clinical diagnostic ultrasound. In this work, we fabricated lipid NBs agent evaluated its passive targeting vivo. showed were (436.8 ± 5.7 nm),...
Hypoxia in a solid tumor microenvironment (TME) can lead to the overexpression of hypoxia-inducible factor-1α (HIF-1α), which correlates metastasis. Reactive oxygen species (ROS) induced cell apoptosis is becoming promising method treatment. Currently, ROS generating systems, e.g., photodynamic treatment and sonodynamic treatment, highly depend on (O2) (TME). However, level O2 TME too low produce enough ROS. Herein, we developed an ultrasmall DSPE-PEG2000 coated barium titanate nanoparticle...
Tumor immunotherapy based on immune checkpoint blockade (ICB) still suffers from low host response rate and non-specific distribution of inhibitors, greatly compromising the therapeutic efficiency. Herein, cellular membrane stably expressing matrix metallopeptidase 2 (MMP2)-activated PD-L1 blockades is engineered to coat ultrasmall barium titanate (BTO) nanoparticle for overcoming immunosuppressive microenvironment tumors. The resulting M@BTO NPs can significantly promote BTO's tumor...
Because of its high tissue penetrative depth, remote spatiotemporal selectivity, and noninvasive therapeutic features, sonodynamic therapy (SDT) has received much attention in recent years. In the SDT, a tumor-localizing sonosensitizing agent is activated by ultrasound produces greatly reactive oxygen species (ROS) to kill tumor cells. Sonosensitizers, including some organic/inorganic compounds micro/nanoscale sonosensitizers, are an important element SDT. Herein, we will introduce...
This work reports a new strategy in surface fabrication of nano-drug delivery systems to achieve site-specific synergetic chemo-photothermal therapy.
Abstract The antioxidant defense system in malignant cells, which involves enzymes and molecules, is an innate barrier to photodynamic therapy (PDT). Because of the complexity endogenous mechanisms these simply inhibiting individual pathways has a limited effect on improving lethality ROS. To enhance efficacy PDT for tumor treatment, versatile nanoparticle (NP)‐based drug developed, authors call PZB NP, containing glutathione inhibitor l ‐buthionine sulfoximine (BSO) heme oxygenase 1 (HO‐1)...
Abstract Synthesized melanin nanoparticles (SMNPs) are used as advanced photothermal materials. However, their internal structures complex and disordered, tuning the performance of is still a hot spot concern. This article presents thionin (Th)‐doped SMNPs, namely Th‐SMNPs, which first SMNPs formed using one‐pot polymerization Th with Levodopa. can undergo Michael addition Schiff base reaction between indole dihydroxy/indolequinone oligomers to form donor–acceptor pairs in structure modulate...
Thermosensitive liposomes have demonstrated great potential for tumor-specific chemotherapy. Near infrared (NIR) dyes loaded also shown improved photothermal effect in cancer theranostics. However, the instability of often causes premature release drugs or dyes, impeding their antitumor efficacy. Herein, we fabricated a highly stable thermo-responsive bubble-generating liposomal nanohybrid cerasome with silicate framework, combined NIR dye to achieve light stimulated, tumor-specific,...
Laser interstitial thermal therapy (LITT), which ablates diseased brain tissues via hyperthermia, has offered novel treatment approach for epilepsy; however, the current LITT protocols still lack ablation selectivity and disease‐modifying efficacy. A second near‐infrared (NIR‐II) activatable nitric oxide (NO) releasing nanoactuator is reported here photothermal combinational modulation of epileptogenic focus. The prepared by conjugating NO donor S‐nitrosoglutathione (GSNO) onto...
Background: Tumor metastasis is responsible for most cancer death worldwide, which lacks curative treatment. Purpose: The objective of this study was to eliminate tumor and control the development metastasis. Methods: Herein, we demonstrated a smart nano-enabled platform, in 2-[2-[2-chloro-3-[(1,3-dihydro-3,3-dimethyl-1-propyl-2h-indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-3,3-dimethyl-1-propylindolium iodide (IR780) tirapazamine (TPZ) were co-loaded...