A5068085404- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Metabolism, Diabetes, and Cancer
- Pharmacological Effects of Natural Compounds
- Genetics and Neurodevelopmental Disorders
- Autophagy in Disease and Therapy
- Wnt/β-catenin signaling in development and cancer
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- Diabetes Treatment and Management
- Drug Transport and Resistance Mechanisms
- Pancreatitis Pathology and Treatment
- Herpesvirus Infections and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroendocrine Tumor Research Advances
- Alzheimer's disease research and treatments
- SARS-CoV-2 and COVID-19 Research
- Lymphoma Diagnosis and Treatment
- Healthcare and Venom Research
Ankang University
2025
Zhejiang Chinese Medical University
2016-2025
Jiaxing University
2025
Sichuan University
2023-2025
First Affiliated Hospital of Wannan Medical College
2006-2025
Nanjing Medical University
2013-2025
Soochow University
2021-2025
Guilin Medical University
2025
State Key Laboratory of Oncology in South China
2024
Sun Yat-sen University
2024
Cytoplasmic STAT3, after activation by growth factors, translocates to different subcellular compartments, including nuclei and mitochondria, where it carries out biological functions. However, the precise mechanism which STAT3 undergoes mitochondrial translocation subsequently regulates tricarboxylic acid (TCA) cycle-electron transport chain (ETC) remains poorly understood. Here, we clarify this process visualizing acetylation in starved cells serum reintroduction or insulin stimulation....
Background Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer with dismal prognosis and few effective therapeutic approaches. This study aimed to investigate the efficacy, safety, predictive biomarkers of hepatic arterial infusion chemotherapy (FOLFOX-HAIC) in combination lenvatinib PD-1 inhibitor for patients advanced iCCA. Methods Locally or metastatic iCCA receiving triple therapy lenvatinib, inhibitor, FOLFOX-HAIC were included this retrospective study. Primary endpoint...
ABSTRACT The anterior segment of the vertebrate eye is constructed by proper spatial development cells derived from surface ectoderm, which become corneal epithelium and lens, neuroectoderm (posterior iris ciliary body) cranial neural crest (corneal stroma, endothelium iris). Although coordinated interactions between these different cell types are presumed to be essential for positioning differentiation, requisite intercellular signals remain undefined. We have generated transgenic mice that...
Background: To investigate the relationship between CXCR4-related circular RNAs (circRNAs) in exosomes and lymph node metastasis of lung adenocarcinoma. Methods: Totally 41 adenocarcinoma tissues (21 with 20 without) were collected. Expression CXCR4 protein was detected by western blotting analysis. A stable PC9/CXCR4-shRNA PC14/CXCR4-shRNA knockdown cell lines established subjected to functional assays (cell proliferation, colony formation, migration invasion) for phenotype changes....
Non-small cell lung cancer (NSCLC) patients carrying an epidermal growth factor receptor (EGFR) mutation are initially sensitive to EGFR-tyrosine kinase inhibitors (TKIs) treatment, but soon develop acquired resistance. The treatment effect of EGFR-TKIs-resistant NSCLC still faces challenges. Cucurbitacin B (CuB), a triterpene hydrocarbon compound isolated from plants various families and genera, elicits anticancer effects in variety types. However, whether CuB is viable option for...
Background: Cerebral ischemia-reperfusion injury is caused by a blood reperfusion in the ischemic brain and usually occurs treatment stage of disease, which can aggravate tissue injury. Objective: Curcumin was reported to exert good therapeutic effect on neural cells against ischemia- injury, However, mechanism not clear. Methods: In this study, Oxygen-Glucose Deprivation (OGD) model fetal rat cerebral cortical neurons Middle Artery Occlusion (MCAO) rats were employed mimic vitro vivo,...
Exploring the mechanism through which berberine (Ber) reverses multidrug resistance (MDR) of breast cancer is great importance. Herein, we used methyl thiazolyl tetrazolium assay to determine drug and cytotoxicity Ber doxorubicin (DOX) alone or in combination on cell line MCF-7/DOXFluc. The results showed that could synergistically enhance inhibitory effect DOX tumor proliferation vitro, optimal ratio was Ber/DOX = 2:1. Using a luciferase reporter system combined with bioluminescence imaging...
Abnormal iron metabolism, mitochondrial dysfunction and the derived oxidative damage are main pathogeneses of Friedrich's ataxia (FRDA), a single-gene inherited recessive neurodegenerative disease characterized by progressive cerebellar sensory ataxia. This is caused frataxin (FXN) mutation, which reduces FXN expression impairs sulfur cluster biogenesis. To date, there no effective therapy to treat this condition. Curcumin proposed harboring excellent ability resist stress through Nrf2...
Cytokine-activated receptors undergo extracellular domain dimerization, which is necessary to activate intracellular signaling pathways. Here, we report that in prolactin (PRL)-treated cells, PRL receptor (PRLR) undergoes cytoplasmic loop dimerization acetylation-dependent. PRLR-recruited CREB-binding protein (CBP) acetylates multiple lysine sites randomly distributed along the of PRLR. Two PRLR monomers appear interact with each other at parts from membrane-proximal region membrane-distal...
Heme oxygenase-1 (HO-1) potently influences tumor growth and metastasis. To date, no study has been performed on HO-1 expression pattern its clinicopathological significance in human gastric cancer (GC) cases. In this study, the of GC tissues ( n = 74) matched non-tumoral adjacent parenchyma 46) was investigated by immunohistochemistry. The correlation with characteristics analyzed. Results showed that expressed 62 from 74 cases (83.8%), which is significantly higher than (20/46, 43.8%, P...