A5033903495- Neurotransmitter Receptor Influence on Behavior
- Language Development and Disorders
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Reading and Literacy Development
- Neuroendocrine regulation and behavior
- Neurobiology of Language and Bilingualism
- Schizophrenia research and treatment
- Nicotinic Acetylcholine Receptors Study
- Regulation of Appetite and Obesity
- Memory and Neural Mechanisms
- Syntax, Semantics, Linguistic Variation
- Phonetics and Phonology Research
- Pharmacology and Obesity Treatment
- Stress Responses and Cortisol
- Attention Deficit Hyperactivity Disorder
- Parkinson's Disease Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Biochemical Analysis and Sensing Techniques
- Child and Animal Learning Development
- Diet and metabolism studies
- Psychedelics and Drug Studies
- Neurological disorders and treatments
- Natural Language Processing Techniques
- Eating Disorders and Behaviors
University of Toronto
2016-2025
Centre for Addiction and Mental Health
2016-2025
University of Kansas Medical Center
2021-2025
University College Cork
2009-2023
University of Cambridge
2009-2021
Cambridge University Hospitals NHS Foundation Trust
2021
Smiths Detection (Canada)
2020
Fulbourn Hospital
2020
Wellcome/MRC Institute of Metabolic Science
2019-2020
Wellcome Trust
2020
A pronounced speech and language disorder affecting half of the 30 members four-generational KE family has been attributed by some researchers to a specific defect in generation morphosyntactic rules. The reported selectivity impairment led view that affected suffer from grammar-specific disorder. Our investigations same indicate inherited broad phenotype which transcends impaired syntactical rules includes striking articulatory as well defects intellectual, linguistic, orofacial praxic...
This study examined the role of phonological awareness and visual-orthographic skills in Chinese reading acquisition. The subjects were 154 1st, 2nd, 3rd, 5th graders Beijing who had learned an alphabetic script known as Hanyu Pinyin to help read characters. Children's performance on tests various cognitive skills, ability, pinyin knowledge examined. Results hierarchical regression analyses showed that (a) visual predicted success at lower grades; (b) ability discriminate homophonic...
BACKGROUND AND PURPOSE To evaluate the hypothesis that activation of somatodendritic 5‐HT 1A autoreceptors in dorsal raphe nucleus (DRN) produces anti‐emetic/anti‐nausea effects cannabidiol (CBD), a primary non‐psychoactive cannabinoid found cannabis. EXPERIMENTAL APPROACH The potential systemic and intra‐DRN administration receptor antagonists, WAY100135 or WAY100635, to prevent anti‐emetic effect CBD shrews ( Suncus murinus) anti‐nausea‐like (conditioned gaping) rats were evaluated. Also,...
Importance Preclinical, observational, and pharmacoepidemiology evidence indicates that glucagon-like peptide 1 receptor agonists (GLP-1RAs) may reduce alcohol intake. Randomized trials are needed to determine the clinical significance of these findings. Objective To evaluate effects once-weekly subcutaneous semaglutide on consumption craving in adults with use disorder (AUD). Design, Setting, Participants This was a phase 2, double-blind, randomized, parallel-arm trial involving 9 weeks...
Purpose Recent research suggests that nonword repetition (NWR) and sentence (SR) tasks can be used to discriminate between children with SLI their typically developing age-matched (TDAM) younger (TDY) peers. Method Fourteen Cantonese-speaking 30 of TDAM TDY peers were compared on NWR SR tasks. IN nonwords (CV combinations attested in the language) OUT unattested compared. performance was using 4 different scoring methods. Results The group did not score significantly lower than test (overall...
ABSTRACT Understanding how words are created is potentially a key component to being able learn and understand new vocabulary words. However, research on morphological awareness relatively rare. In this study, over 660 preschool-aged children from three language groups (Cantonese, Mandarin, Korean speakers) in which compounding morphology highly prevalent were tested their abilities manipulate familiar morphemes create novel compound as well variety of early reasoning measures twice the span...
The present series of studies were designed to investigate the 5-HT(2C) receptor agonist Ro 60-0175 on cocaine- and food-maintained behavior in rat. (0.1-3 mg/kg, s.c.) reduced cocaine (15 i.p.)-induced hyperactivity. This inhibitory effect (1 was completely blocked by pretreatment with selective antagonist SB 242,084 (0.5 i.p.). In further studies, (1-3 responding for both food (45-mg Noyes pellet) (0.25 mg/infusion) maintained under identical schedules reinforcement (fixed ratio (5), time...
The distribution and function of neurons coexpressing the dopamine D1 D2 receptors in basal ganglia mesolimbic system are unknown. We found a subset medium spiny varying densities throughout ganglia, with highest incidence nucleus accumbens globus pallidus lowest caudate putamen. These formed D1-D2 receptor heteromers that were localized to cell bodies presynaptic terminals. In rats, selective activation increased grooming behavior attenuated AMPA GluR1 phosphorylation by calcium/calmodulin...
Abstract Background Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded by two genes that generate related proteins: GSK-3α GSK-3β. Mice lacking functional gene were engineered in our laboratory; they are viable display insulin sensitivity. In this study, we have characterized brain functions of KO mice using well-established battery behavioral tests together with neurochemical neuroanatomical analysis. Results Similar to the...
Although there has been much debate over the content of children's first words, few large sample studies address this question for children at very earliest stages word learning. The authors report data from comparable samples 265 English-, 336 Putonghua- (Mandarin), and 369 Cantonese-speaking 8- to 16-month-old infants whose caregivers completed MacArthur-Bates Communicative Development Inventories reported them produce between 1 10 words. Analyses individual words indicated striking...
Stimulation of the prefrontal cortex by acetylcholine is critical for attention; however, cellular mechanisms underlying its influence on attention pathways within brain are not well understood. Pyramidal neurons in layer VI believed to play an important role this process because they excited and provide a major source feedback projections thalamus. Here, we show using whole-cell electrophysiology that relatively rare α5 subunit nicotinic receptor powerfully enhances currents pyramidal...