A5101577351- Advanced Sensor and Energy Harvesting Materials
- Conducting polymers and applications
- Dielectric materials and actuators
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- Analytical Chemistry and Sensors
- Electronic and Structural Properties of Oxides
- Adipose Tissue and Metabolism
- Metal-Organic Frameworks: Synthesis and Applications
- Concrete and Cement Materials Research
- Liver Disease Diagnosis and Treatment
- Advanced Photocatalysis Techniques
- Nuclear materials and radiation effects
- Distributed systems and fault tolerance
- Ferroptosis and cancer prognosis
- Electromagnetic wave absorption materials
- TiO2 Photocatalysis and Solar Cells
- Adipokines, Inflammation, and Metabolic Diseases
- X-ray Diffraction in Crystallography
- MicroRNA in disease regulation
- biodegradable polymer synthesis and properties
- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- Diet, Metabolism, and Disease
- Lanthanide and Transition Metal Complexes
Dalian Medical University
2019-2025
First Affiliated Hospital of Dalian Medical University
2019-2025
Wuhan Polytechnic University
2025
Tianjin University of Science and Technology
2024
Peking University Cancer Hospital
2019-2024
Jiujiang University
2018-2024
Yulin University
2015-2024
Peking University
2019-2024
Shanghai University
2023-2024
Nanchang University
2021-2024
Targeting PLK1 has recently been proven as a viable therapeutic strategy against oesophageal squamous cell carcinom (ESCC). Therefore, this study aimed to explore whether the inhibitor BI2536 is able sensitize ESCC cells cisplatin (DDP) and determine underlying mechanisms.Viability, clonogenicity, cycle distribution apoptosis were assessed in treated with or DDP alone combination. Checkpoint activation was examined by immunoblotting immunohistochemistry. Xenograft model used assess efficacy...
Enhancing the output performance of triboelectric nanogenerators through surface modification, mechanical design and power management.
Abstract Cyclin-dependent kinase 7 (CDK7) serves as a pivotal regulator in orchestrating cellular cycle dynamics and gene transcriptional activity. Elevated expression levels of CDK7 have been ubiquitously documented across spectrum malignancies concomitantly correlated with adverse clinical outcomes. This review delineates the biological roles explicates molecular pathways through which exacerbates oncogenic progression breast cancer. Furthermore, we synthesize extant literature to provide...
The photophysical properties of two newly synthesized photoactive compounds with asymmetrical D-pi-A structure and symmetrical D-pi-A-pi-D are investigated in different aprotic solvents by steady-state femtosecond fluorescence depletion measurements. It is found that the DA compound has larger dipole moment change than DAD upon excitation, where moments have been estimated using Lippert-Mataga equation. Furthermore, spectral results show increasing solvent polarity small solvatochromic shift...
8017 Background: Despite high response rates to EGFR tyrosine kinase inhibitors (TKIs), most patients (pts) with EGFR-mut NSCLC ultimately relapse. Dysregulation of the MET pathway is implicated as a therapeutically tractable resistance mechanism, occurring in 15–20% cases. INC280 highly selective, oral inhibitor preclinical activity EGFR-mut/MET-activated when combined TKIs. Methods: This Ph Ib/II, open-label, dose-escalation study plus gef was performed pts (age ≥18 yrs, ECOG PS ≤2) who...
Thyroxine metabolism is an important topic of pathogenesis research and treatment schedule subclinical hypothyroidism (SCH). L-thyroxine replacement therapy (LRT) usually recommended for severe SCH patients only. Our previous studies reported that disordered serum lipid mild people could also benefit from LRT. However, the benefits were different among individuals, as shown by variations drug dosage required to maintain TSH stability. Alternative pathways, such sulfation glucuronidation...
Herein, SrSnO3 perovskite and Nd2Sn2O7 pyrochlore with definite structures have been synthesized using a hydrothermal method, the differences in their reactive sites for oxidative coupling of methane (OCM) are investigated. The primary products C2 hydrocarbons COx, respectively. selectivity is primarily affected by basic chemisorbed oxygen species O22-. For pyrochlore, key factors affecting conversion COx acidic (chemisorbed weakly bonded lattice oxygen). directly generated through intrinsic...
To enhance the toughness and electrical insulation properties of cured epoxy, carboxyl-terminated polybutadiene (CTPB) liquid rubber was used to modify epoxy in this study, thermal conductivity, mechanical dielectric modified were investigated. The results indicate that CTPB-epoxy exhibits higher impact strength lower constant loss compared with pure epoxy. Further, hexagonal boron nitride (hBN) reinforce 20 phr CTPB. It is found hBN/epoxy under same filler loading, heat conductive...
Low-grade thermal energy can be converted to electricity by integrating multi-effect distillation and reverse electrodialysis technologies. The conversion efficiency of such a system is strongly influenced the working solution. Here, six binary solutions (LiCl/LiBr/LiI in H2O LiCl/LiBr/LiI methanol) three ternary methanol mixture) are assessed as candidate solutions. Electrical conductivities these were measured over wide concentration range (up 12.4 mol·kg–1), results examined with...
Insulating interlayer between nanoparticles and polymer matrix is crucial for suppressing the dielectric loss of composites. In this study, titanium carbide (TiC) particles were surface modified by polydopamine (PDA), obtained PDA@TiC powders used to reinforce thermoplastic polyurethane (TPU). The results indicate that homogenously dispersed in compared with pristine TiC, PDA@TiC/TPU composites show improved mechanical properties, i.e., much lower dissipation factors obviously enhanced...
Abstract MicroRNAs (miRNAs), the potential regulator of adipogenesis, markedly characterized by lipid droplet (LD) formation, play an important role in progenitor‐cell differentiation into adipocytes. In recent years, it has excited interests regulation miRNAs adipogenesis. However, no study is available, to our knowledge, regarding expression on LD formation. Our provides first insight profiling miRNA targeting messenger RNAs (mRNAs) involving with formation during adipogenesis from human...
Diabetic cardiomyopathy is mediated by multiple molecular mechanisms including endoplasmic reticulum (ER) stress. Curcumin, a phenolic compound, has cytoprotective properties, but its potential protective action against diabetic and the related are not fully elucidated. In this study, we evaluated effects of curcumin on cell viability apoptosis in palmitic acid (PA)-treated H9C2 cardiomyocytes investigated signaling pathways involved. Treatment with PA reduced viability, induced apoptosis,...
We prove that "FIFO" worksharing protocols provide asymptotically optimal solutions to a problem related sharing bag of identically complex tasks in heterogeneous network workstations (HNOW) n. In the HNOW-Exploitation Problem, one seeks accomplish as much work possible on n during prespecified fixed period L time units. The we study are crafted within an architectural model characterizes via parameters measure workstations' computational and communicational powers. self-scheduling, they...
Surface modification of core‐shell structured Al (Al@Al 2 O 3 ) nanoparticles was performed using γ ‐(Aminopropyl)‐triethoxysilane (APS) and dopamine (DA), respectively, the microstructures, dielectric properties thermal conductivities Al/poly(vinylidene fluoride) (PVDF) nanocomposites were investigated. Both DA APS enhance interfacial bonding strength between fillers matrix, leading to homogeneous dispersion in PVDF matrix. Compared with raw nanoparticles, surface‐treated Al/PVDF exhibit...