A5038643381- Gut microbiota and health
- Cancer-related Molecular Pathways
- Inflammatory Bowel Disease
- Magnetic and Electromagnetic Effects
- Natural Language Processing Techniques
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Plant biochemistry and biosynthesis
- Plant Parasitism and Resistance
- Plant Reproductive Biology
- Natural product bioactivities and synthesis
- Peptidase Inhibition and Analysis
- Diet and metabolism studies
- Plant Virus Research Studies
- Fungal Biology and Applications
- Topic Modeling
- Mycorrhizal Fungi and Plant Interactions
- RNA modifications and cancer
- Biochemical and Structural Characterization
- Helicobacter pylori-related gastroenterology studies
- Magnetic Properties of Alloys
- Immune responses and vaccinations
- Seed Germination and Physiology
Peking University
2018-2025
Peking University Cancer Hospital
2018-2025
Southwest Medical University
2025
Wuhan University
2022-2025
Renmin Hospital of Wuhan University
2022-2025
Heilongjiang University of Chinese Medicine
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Xuzhou University of Technology
2023-2024
Tianjin Nankai Hospital
2024
Tianjin Medical University
2024
Targeting PLK1 has recently been proven as a viable therapeutic strategy against oesophageal squamous cell carcinom (ESCC). Therefore, this study aimed to explore whether the inhibitor BI2536 is able sensitize ESCC cells cisplatin (DDP) and determine underlying mechanisms.Viability, clonogenicity, cycle distribution apoptosis were assessed in treated with or DDP alone combination. Checkpoint activation was examined by immunoblotting immunohistochemistry. Xenograft model used assess efficacy...
Background: Dental caries is the most prevalent bacterial biofilm-induced disease.Current clinical prevention and treatment agents often suffer from adverse effects on oral microbiota diversity normal tissues, predominately arising poor biofilm-targeting property of agents.Methods: To address this concern, we herein report dual-sensitive antibacterial peptide nanoparticles pHly-1 NPs upon acid lipid-binding for dental caries.Amino substitutions were performed to design pHly-1.The potential,...
The pathogenesis of ulcerative colitis (UC) is unclear, while genetic factors have been confirmed to play an important role in its development.P2RY13 a G protein-coupled receptor (GPCRs), which are involved the inflammation and immune disorders.According GEO database analysis, we first observed that expression P2Y13 was increased UC patients.Therefore, sought determine development colitis.Our data showed P2RY13 highly expressed inflamed intestinal tissues patients.In mice, pharmacological...
Abstract Reprogrammed cellular metabolism is essential for maintaining cancer stem cells (CSCs) state. Here, we report that mitochondrial D-lactate catabolism a necessary initiating oncogenic event during tumorigenesis of esophageal squamous cell carcinoma (ESCC). We discover cyclin-dependent kinase 7 (CDK7) phosphorylates nuclear Yes-associated protein 1 (YAP) at S127 and S397 sites enhances its transcription function, which promotes dehydrogenase (LDHD) expression. Moreover, LDHD enriched...
Abstract The Western diet, characterized by its high content of long-chain fatty acids (LCFAs), is widely recognized as a significant triggering factor for inflammatory bowel disease (IBD). While the link between high-fat diet and colitis has been observed, specific effects mechanisms remain incompletely understood. Our study provides evidence that rich in LCFAs can disrupt integrity intestinal barrier exacerbate experimental mice. Mechanistically, upregulate signal transducer activator...
To investigate the current situation of mental psychology and quality life (QoL) in patients with inflammatory bowel disease (IBD) China, analyze influencing factors.
Background/Aim The aim of this study is to determine the relationship between stromal types, PD-L1 status and clinicopathological characteristics in patients with different molecular subtypes breast cancer. Materials methods Protein expression levels were determined by immunohistochemistry assay. Stromal type was classified based on maturity tumor stroma. Results Different cancer had distinct types. Tumors from mature stroma lower pathological N stage AJCC stage, more frequent high p53...
Real-time quantitative polymerase chain reaction (RT-qPCR) is a sensitive technique for gene expression studies. However, choosing the appropriate reference essential to obtain reliable results RT-qPCR assays. In present work, of eight candidate genes, EF1-α (elongation factor 1-α), GAPDH (glyceraldehyde 3-phosphate dehydrogenase), UBC (ubiquitin-conjugating enzyme), UBQ (polyubiquitin), ACT (actin), β-TUB (β-tubulin), APT1 (adenine phosphoribosyltransferase 1), and 18S rRNA (18S ribosomal...
Breast cancer susceptibility gene 1 (BRCA1) has been implicated in modulating metabolism via transcriptional regulation. However, direct metabolic targets of BRCA and the underlying regulatory mechanisms are still unknown. Here, we identified several genes, including which encodes glutamate‐oxaloacetate transaminase 2 ( GOT 2), a key enzyme for aspartate biosynthesis, repressed by 1. We report that forms co‐repressor complex with ZBRK coordinately represses expression recognition element...
Reactive oxygen species (ROS) localized at the precise subcellular compartments are essential for regulating activity of signaling proteins. Furthermore, ROS master regulators tumor malignant progression that respond to a diverse set environmental stress, especially hypoxia. NADPH oxidases (NOXs) appear be activated within discrete facilitate local production. However, function NOXs in hypoxic is still unclear. In this study, we demonstrated NOX5 was greatly upregulated clinical esophageal...
Vulvovaginal candidiasis is a common fungal infection afflicting women which primarily caused by the yeast
Abstract Epidermal growth factor receptor (EGFR) is one of the most common amplified and overexpressed oncogenes in esophageal squamous cell carcinoma (ESCC), while clinical efficacy EGFR-targeted therapy ESCC dismal. Here, we evaluated dual blockage using monoclonal antibody against EGFR (Nimotuzumab) an Wee1 inhibitor (AZD1775) ESCC. We found that mRNA protein expression were positively correlated Nimotuzumab-AZD1775 co-treatment inhibited tumor PDX models with different drug...
Gut microbiota dysbiosis has been reported as a risk factor in the development of type 2 diabetes mellitus (T2DM). Polysaccharides from
Abstract Ubiquitin-specific protease 25 (USP25), a member of the deubiquitination family, plays an important role in protein ubiquitination, degradation, inflammation, and immune regulation. However, mechanism USP25 ulcerative colitis (UC) remain unclear. To study UC, bioinformatics analysis research are conducted on clinical patients with Usp25 knockout ( −/− ) mice, intestinal epithelial cell-specific signal transducer activator transcription 3 Stat3) (Villin-Cre Stat3 fl/fl human colonic...