A5070712828- Nerve injury and regeneration
- Electrospun Nanofibers in Biomedical Applications
- Spinal Cord Injury Research
- Nerve Injury and Rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Trace Elements in Health
- Extracellular vesicles in disease
- Cell death mechanisms and regulation
- Periodontal Regeneration and Treatments
- Ferroptosis and cancer prognosis
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
Peking University
2017-2021
Peking University People's Hospital
2017-2021
Chinese PLA General Hospital
2018
Shihezi University
2016
Targeting PLK1 has recently been proven as a viable therapeutic strategy against oesophageal squamous cell carcinom (ESCC). Therefore, this study aimed to explore whether the inhibitor BI2536 is able sensitize ESCC cells cisplatin (DDP) and determine underlying mechanisms.Viability, clonogenicity, cycle distribution apoptosis were assessed in treated with or DDP alone combination. Checkpoint activation was examined by immunoblotting immunohistochemistry. Xenograft model used assess efficacy...
At present, repair methods for peripheral nerve injury often fail to get satisfactory result. Although various strategies have been adopted investigate the microenvironment after injury, underlying molecular mechanisms of neurite outgrowth remain unclear. In this study, we evaluate effects exosomes from gingival mesenchymal stem cells (GMSCs) combined with biodegradable chitin conduits on regeneration. GMSCs were isolated human tissue and characterized by surface antigen analysis in vitro...
Various artificial materials have been fabricated as alternatives to autologous nerve grafts in peripheral regeneration, and these afford positive recovery effects without the disadvantages of gold standard. In this study, we prepared a three-dimensional functionalized self-assembling peptide nanofiber hydrogel containing two neurotrophic peptides (CTDIKGKCTGACDGKQC RGIDKRHWNSQ derived from growth factor brain-derived factor, respectively) that reflected structure properties neural...
Articular cartilage defects are difficult to treat, but drug-loaded tissue engineering scaffolds provide a possible treatment option for these types of injuries.
Peripheral nerve injury has troubled clinical doctors for many years. To obtain better function recovery of peripheral repair at the base hollow guidance conduit (NGC), NGCs with fillers were developed in application tissue-engineered graft. In this study, expanded 3D nanofibre sponge scaffolds orientation and porosity first fabricated by electrospinning gas-foaming technique. Polylactic acid (PLA)/silk fibroin prepared as filler to construct sponges containing NGC (SNGC). SNGC could promote...
Cartilage defect is common in clinical but notoriously difficult to treat for low regenerative and migratory capacity of chondrocytes. Biodegradable tissue engineering nano-scaffold with a lot advantages has been the direction material repair cartilage recent years. The objective our study establish biodegradable drug-loading synthetic polymer (PLA) biopolymer (Gelatine) composite 3D support treatment defect. We designed microfluidic chip-based drug-screening device select optimum...
The extracellular matrix, which includes collagens, laminin, or fibronectin, plays an important role in peripheral nerve regeneration. Recently, a Schwann cell-derived matrix with classical biomaterial was used to mimic the neural niche. However, extensive clinical use of cells remains limited because origin, loss autologous nerve, and extended vitro culture times. In present study, human umbilical cord-derived mesenchymal stem (hUCMSCs), are easily accessible more proliferative than cells,...
Peripheral nerve injury is a common clinical problem because the dysfunction of distal limb seriously affects patients' quality life, and it results in huge social economic burden.[1] Repair peripheral very complex pathological process. Due to slow regeneration, Wallerian degeneration stump, tissue adhesion, atrophy muscles motor end plates other constraints, functional rehabilitation damaged always restricted. The ultimate goal repairing injuries restore function target organs their...
Peripheral nerve injury is a significant clinical problem with substantial impact on quality of life, for which no optimal treatment has been found. This study aimed to analyze the effect and mechanism Wnt5a-loaded fibrin hydrogel 10-mm rat sciatic defect.The was synthesized by mixing Wnt5a solution thrombin fibrinogen solutions. The loading capacity release profile Schwann cells were evaluated in vitro. We also assessed vivo repair status via histological analysis regenerative gastrocnemius...