A5042076387- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Spinal Cord Injury Research
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Injury Epidemiology and Prevention
- Trauma and Emergency Care Studies
- Wound Healing and Treatments
- Emergency and Acute Care Studies
- Tendon Structure and Treatment
- Peripheral Nerve Disorders
- Traffic and Road Safety
- Bone fractures and treatments
- Shoulder Injury and Treatment
- Hip and Femur Fractures
- Neuroscience and Neural Engineering
- Spinal Fractures and Fixation Techniques
- Reconstructive Surgery and Microvascular Techniques
- Pelvic and Acetabular Injuries
- Orthopaedic implants and arthroplasty
- Bone and Joint Diseases
- Medicinal Plant Pharmacodynamics Research
- Neuropeptides and Animal Physiology
- Magnesium Alloys: Properties and Applications
- Signaling Pathways in Disease
Peking University
2015-2024
Peking University People's Hospital
2015-2024
Guangdong Pharmaceutical University
2024
State Administration of Foreign Experts Affairs
2019-2021
Qingdao University
2020
Affiliated Hospital of Qingdao University
2020
Southwest Medical University
2020
King University
2019
Peking Union Medical College Hospital
2013
Chinese Academy of Medical Sciences & Peking Union Medical College
2013
Abstract The most severe sequelae after rehabilitation from SARS are femoral head necrosis and pulmonary fibrosis. We performed a 15-year follow-up on the lung bone conditions of patients. evaluated recovery damage in an observational cohort study patients using CT scans, hip joint MRI examinations, function tests questionnaires. Eighty medical staff contracted 2003. Two died SARS, 78 were enrolled this August 2003 to March 2018. Seventy-one completed follow-up. percentage lesions scans...
Autologous nerve transplantation, which is the gold standard for clinical treatment of peripheral injury, still has many limitations.In this study, aligned chitosan fiber hydrogel (ACG) grafted with a bioactive peptide mixture consisting RGI (Ac-RGIDKRHWNSQGG) and KLT (Ac-KLTWQELYQLKYKGIGG), designated as ACG-RGI/KLT, was used conduit filler to repair sciatic defects in rats.Methods: Chitosan nanofiber prepared by combination electrospinning mechanical stretching methods, then KLT, are...
Ternary magnesium alloys with low combined addition of elements gadolinium and zinc were developed in the present work, their microstructures, mechanical properties, vitro degradation behaviors, cytotoxicity being systematically studied. Furthermore, Mg-1.8Zn-0.2Gd alloy, best performance, was implanted into Sprague Dawley rats to examine its vivo performance for up 6 months. It found that Mg-1.8Zn-0.2Gd, composed a single α-Mg phase, owned excellent strength toughness comparable CE marked...
Motor endplates (MEPs) are the important interfaces between peripheral nerves and muscle fibers. Investigation of spatial distribution MEPs could help us better understand neuromuscular functional activities improve diagnosis therapy related diseases. Methods: Fluorescent α-bungarotoxin was injected to label motor in whole-mount skeletal muscles, tissue optical clearing combined with light-sheet microscopy used investigate in-muscle nerve branches different muscles wild-type transgenic...
Electrical stimulation (ES) has been proven to be an effective means of enhancing the speed and accuracy nerve regeneration. However, these results were recorded when procedure was performed almost immediately after injury. In clinical settings, most patients cannot treated immediately. Some with serious trauma or contaminated wounds need wait for repair surgery. Delays in have shown associated poorer than immediate It is not clear whether electrical still any effect on regeneration enough...
Although autologous nerve transplantation is the gold standard for treating peripheral defects, it has many clinical limitations. As an alternative, various tissue-engineered grafts have been developed to substitute nerves. In this study, a novel graft composed of chitin scaffolds and small was used repair sciatic defects in rats. The greatly facilitated regeneration myelin sheath, reduced atrophy target muscle, effectively restored neurological function. When epineurium autogenous removed,...
Radix Hedysari is an herbal preparation frequently used in traditional Chinese medicine. It can promote regeneration after peripheral nerve injury, but its effect on the amplification ratio (the of distal to proximal fibers) during has not yet been examined. In this study, we explored extract nerve. Male Sprague-Dawley rats were separated into three groups at random: normal group (without surgery), model (given sleeve bridging surgery, without adjuvant treatment) and treatment surgery then...
Effects of Epimedium extract and its constituent icariin on peripheral nerve repair were investigated in a crush injury rat model. Animals divided into four groups: sham, control, extract, groups. At postoperative weeks 1, 2, 4, 8, regeneration functional recovery evaluated by sciatic index (SFI), electrophysiology, pinch test, muscle wet weight. Results showed that at 2 4 after surgery rats the group displayed better function than control groups, with group. The test was greater as compared...
Peripheral nerve injury is a common clinical problem because the dysfunction of distal limb seriously affects patients' quality life, and it results in huge social economic burden.[1] Repair peripheral very complex pathological process. Due to slow regeneration, Wallerian degeneration stump, tissue adhesion, atrophy muscles motor end plates other constraints, functional rehabilitation damaged always restricted. The ultimate goal repairing injuries restore function target organs their...
Our previous study showed that systemic administration of the traditional Chinese medicine Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore therapeutic effects local icariin, a major component extract, on A poly(lactic-co-glycolic acid) biological conduit sleeve was used bridge 5 mm right sciatic defect in rats, and physiological saline, growth factor, icariin suspension, or factor-releasing microsphere suspension injected into defect. Twelve weeks later,...
Abstract Aims Peripheral nerve defects are often difficult to recover from, and there is no optimal repair method. Therefore, it important explore new methods of repairing peripheral defects. This study explored the efficacy grafts constructed from chitin biological conduits combined with small autogenous nerves (SANs) platelet‐rich plasma (PRP) for 10‐mm sciatic in rats. Methods To prepare defects, SANs were first harvested PRP was extracted. The consisted SAN PRP, used rat These...
We examined the restorative effect of modified biodegradable chitin conduits in combination with bone marrow mesenchymal stem cell transplantation after right spinal cord hemisection injury. Immunohistochemical staining revealed that biological conduit sleeve bridging reduced glial scar formation and muscular atrophy hemisection. Bone cells survived proliferated vivo, differentiated into double-positive for S100 (Schwann marker) fibrillary acidic protein (glial at 8 weeks. Retrograde tracing...
This study aimed to evaluate the effects of standard rescue procedure (SRP) in improving severe trauma treatments China.This was conducted 12 hospitals located geographically and industrially different cities China. A on established as a general rule for staff training patient treatment. regional network (system) efficiently integrating prehospital rescue, emergency room treatments, hospital specialist built under information sharing treatments. Treatment outcomes were compared between...