Polypyrrole nanoparticles conjugating gadolinium chelates were successfully fabricated for dual‐modal magnetic resonance imaging (MRI) and photoacoustic guided photothermal therapy of cancer, from a mixture pyrrole pyrrole‐1‐propanoic acid through facile one‐step aqueous dispersion polymerization, followed by covalent attachment chelate, using polyethylene glycol as linker. The obtained PEGylated poly­pyrrole (Gd‐PEG‐PPy NPs), sized around 70 nm, exhibited high T 1 relaxivity coefficient...

The high intensity focused ultrasound (HIFU) and thermosensitive cerasomes (HTSCs) were successfully assembled by employing cerasome-forming lipid (CFL) in combination with the component lipids of conventional low temperature sensitive liposomes (LTSLs) including 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG-2000) 1-stearoyl-2-hydroxy-sn-glycero-3-phosphocholine (MSPC). HTSCs showed...

This paper reported the fabrication of a multifunctional nanoplatform by modifying hollow Prussian blue nanoparticles with hyaluronic acid grafting polyethylene glycol, followed loading 10-hydroxycamptothecin for tumor-targeted thermochemotherapy.It was found that surface modification endowed great colloidal stability, long blood circulation time and capability targeting Hela cells over-expressing CD44 receptor.The obtained nanoagent exhibited efficient photothermal effect light triggered...

Multidrug resistance (MDR) poses a great challenge to cancer therapy. It is difficult inhibit the growth of MDR due its chemoresistance. Furthermore, cancers are more likely metastasize, causing high mortality among patients. In this study, nanomedicine RGD-NPVs@MNPs/DOX was developed by encapsulating melanin nanoparticles (MNPs) and doxorubicin (DOX) inside RGD peptide (c(RGDyC))-modified nanoscale platelet vesicles (RGD-NPVs) efficiently metastasis drug-resistant tumors via cells tumor...

Prussian blue nanoparticles were explored for the first time as an excellent contrast agent enhancing photoacoustic tomography in vitro and vivo due to their superior absorption efficiency of near-infrared laser pulses at a wavelength 765 nm.

A multifunctional nanotheranostic agent was developed by conjugating both hyaluronic acid and bovine serum albumin coated CuInS 2 -ZnS quantum dots onto the surface of magnetic Prussian blue nanoparticles.The obtained nanoagent could serve as an efficient contrast to simultaneously enhance near infrared (NIR) fluorescence resonance (MR) imaging greatly.The coexistence core CD44 ligand found largely improve specific uptake overexpressed HeLa cells upon applying external field.Both NIR MR in...

The integration of diagnostic and therapeutic functionalities into one nanoplatform shows great promise in cancer therapy.In this research, manganese (II) chelate functionalized copper sulfide nanoparticles were successfully prepared using a facile hydrothermal method.The obtained ultrasmall exhibit excellent photothermal effect photoaoustic activity.Besides, the high loading content Mn(II) chelates makes attractive T 1 contrast agent magnetic resonance imaging (MRI).In vivo photoacoustic...

A theranostic agent was successfully fabricated by the formation of Au nanoshell around poly(lactic acid) nanoparticles entrapping doxorubicin, followed linking a Mn-porphyrin derivative on shell surface through polyethylene glycol. The resulted exhibited excellent colloidal stability and long blood circulation time due to introducing grafting onto nanoparticle endowed greatly improved relaxivity (r1 value 22.18 mM(-1)s(-1) Mn(3+)), favorable for accurate cancer diagnosing locating tumor...

A novel multifunctional theranostic agent has been successfully fabricated by loading iron oxide nanoparticles into poly(lactic acid) (PLA) microcapsules followed surface functionalization with graphene oxide. Both in vitro and vivo experiments proved that the resulting could serve as contrast agents to simultaneously enhance ultrasound, magnetic resonance photoacoustic imaging. The composite show good biocompatibility rapid response fields. Due strong absorption of near-infrared light,...

This Article reported the fabrication of a robust theranostic cerasome encapsulating indocyanine green (ICG) by incorporating 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)2000]-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid monoamide (DSPE-PEG2000-DOTA), followed chelating radioisotope 177Lu. Its applications in optical and nuclear imaging tumor uptake biodistribution, as well photothermal killing cancer cells, were investigated. It was found that...

Abstract This paper reports the facile design and synthesis of a series lipidic organoalkoxysilanes with different numbers triethoxysilane headgroups hydrophobic alkyl chains linked by glycerol pentaerythritol for construction cerasomes regulated surface siloxane density controlled release behavior. It was found that number affected properties encapsulation efficiency, drug loading capacity, For both water‐soluble doxorubicin (DOX) water‐insoluble paclitaxel (PTX), rate from decreased as...

A bimodal contrast nanoagent was developed by chelating gadolinium ions to 2-[bis[2-[carboxymethyl-[2-oxo-2-(2-sulfanylethyl-amino)ethyl]amino]ethyl]amino]acetic acid (DTDTPA)-modified CuInS2/ZnS quantum dots (QDs). The longitudinal relaxivity (r1) of the resulted QDs@DTDTPA-Gd nanoparticles (NPs) calculated be 9.91 mM–1 s–1, which 2.5 times as high that clinically approved Gd-DTPA (3.9 s–1). In addition, in vivo imaging experiments showed NPs could enhance both near-infrared fluorescence...

Stabilized disc-like hybrid bicelles provide pH-sensitive release, preferable cellular uptake, tumor accumulation and therapeutic effect <italic>in vitro</italic> vivo</italic>.

Abstract: Tumor angiogenesis plays a key role in tumor growth and metastasis; thus, targeting tumor-associated is an important goal cancer therapy. However, the efficient delivery of drugs to tumors remains issue antiangiogenesis GX1, peptide identified by phage-display technology, novel vasculature endothelium-specific ligand possesses great potential as targeted vector antiangiogenic agent diagnosis treatment human cancers. Endostar, recombinant endostatin, has been shown inhibit...

Nanoparticle-based chemophotothermal therapy (CPT) is a promising treatment for multidrug resistant tumors. In this study, drug nanococktail of DIR825@histone was developed by employing doxorubicin (DOX), NIR dye IR825 and human histones interventional nucleus-targeted CPT tumors with an laser. After localized intervention, penetrated tumor tissues transcytosis, efficiently entered cells targeted the cell nuclei. also exhibited good photothermal performance thermal-triggered release....

Chemotherapy is widely used in combination with high-intensity focused ultrasound (HIFU) ablation for cancer therapy; however, the spatial and temporal integration of chemotherapy HIFU remains a challenge. Here, temperature-sensitive plateletsomes (TSPs) composed platelet (PLT) membrane, 1-stearoyl-2-hydroxy-sn-glycero-3-phosphocholine 1,2-dipalmitoyl-sn-glycero-3-phosphocholine were developed to adequately integrate tumor vivo. Methods: The thermosensitive permeability TSPs was evaluated...

By allowing more photons to reach deeper tissue, the optical clearing agent (OCA) has gained increasing attention in various imaging modalities. However, commonly used OCAs have high fluidity, limiting their applications vivo studies with oblique, uneven, or moving surfaces. In this work, we reported an OCA viscosity. We measured properties of viscous OCA, and tested its successful performances a living animal's skin two modalities: photoacoustic microscopy coherence tomography. Our results...

Molecular imaging used in cancer diagnosis and therapeutic response monitoring is important for glioblastoma (GBM) research. Antiangiogenic therapy currently one of the emerging approaches GBM treatment. In this study, a multifunctional nanoparticle was fabricated that can facilitate fluorescence tumor deliver agent to region vivo therefore possesses broad application This particle polylactic acid (PLA) nanoparticles encapsulating Endostar, which further conjugated with GX1 peptide...

Abstract Background Prussian blue (PB) nanoparticles (NPs) have been intensively investigated for medical applications, but an in-depth toxicological investigation of PB NPs has not implemented. In the present study, a comprehensive fate and risks after intravenous administration was carried out by using mouse model integrated methodology pharmacokinetics, toxicology, proteomics, metabolomics. Results General studies demonstrated that at 5 or 10 mg/kg could induce obvious toxicity in mice,...