A5059000515- Immune cells in cancer
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Atmospheric chemistry and aerosols
- Inflammation biomarkers and pathways
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Phagocytosis and Immune Regulation
- Apelin-related biomedical research
- Salivary Gland Disorders and Functions
- Air Quality and Health Impacts
- Mesenchymal stem cell research
- Cytokine Signaling Pathways and Interactions
- Chemokine receptors and signaling
- Immunodeficiency and Autoimmune Disorders
- IL-33, ST2, and ILC Pathways
- Atmospheric aerosols and clouds
- Pregnancy and preeclampsia studies
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Axon Guidance and Neuronal Signaling
- Epigenetics and DNA Methylation
Institute of Earth Environment
2022-2025
Chinese Academy of Sciences
2015-2025
Jiangsu University
2016-2025
Affiliated Hospital of Guizhou Medical University
2025
Guizhou University
2025
Affiliated Hospital of Jiangsu University
2013-2023
Suzhou Institute of Biomedical Engineering and Technology
2021
Ji Hua Laboratory
2021
Zhangjiagang First People's Hospital
2018
Xi'an Jiaotong University
2017-2018
Follicular helper T (Tfh) cells are recognized as a distinct CD4 + T-cell subset, which provides for B-cell activation and production of specific antibody responses, play critical role in the development autoimmune disease. So far, only one study investigated circulating Tfh increased subset SLE patients. Since relatively little is known about rheumatoid arthritis (RA) patients, this study, Tfh-cell frequency, related cytokine IL-21, transcription factor Bcl-6 were 53 patients with RA 31...
Abstract Cancer stem cells play a critical role in colorectal cancer (CRC) progression. Myeloid‐derived suppressor (MDSCs) promote tumor progression through multiple mechanisms CRC. The roles of MDSCs CRC cell stemness are unclear. MDSC‐derived exosomes proposed to act as intercellular messengers. Herein, it is reported that granulocytic (G‐MDSCs) and mice exosomes. It found S100A9, highly expressed G‐MDSC‐derived exosomes, its blockade suppresses the susceptibility AOM/DSS‐induced...
Follicular helper T (Tfh) cells exert an important role in the autoimmune diseases.Our study aimed to explore of Tfh patients with thyroid disease (AITD).Tfh cell is a new subset regulating antibody production B cell. Previous studies implicated CD4+CXCR5+ICOShigh or CD4+CXCR5+PD-1high as markers circulating cells. Sixty-five AITD and 30 healthy controls were enrolled current study. The percentages assessed by flow cytometry. correlation between levels autoantibodies hormones was also...
Although Th17 cells have been increasingly recognised as an important effector in various autoimmune diseases, their function the pathogenesis of Sjögren's syndrome (SS) remains largely uncharacterised. This study aims to determine role development experimental SS (ESS).The ESS was induced wildtype and IL-17A knockout (IL-17 KO) C57BL/6 mice immunised with salivary glands (SG) proteins. Phenotypic analysis immune draining cervical lymph nodes (CLN) SG performed by flow cytometry...
Cell expansion is crucial for plant growth. It well known that the phytohormone ethylene functions in development as a key modulator of cell expansion. However, role regulation this process remains unclear. In study, 2,189 ethylene-responsive transcripts were identified rose (Rosa hybrida) petals using transcriptome sequencing and microarray analysis. Among these transcripts, an NAC (for no apical meristem [NAM], Arabidopsis transcription activation factor [ATAF], cup-shaped cotyledon...
Myeloid-derived suppressor cells (MDSCs) participate in tumor-elicited immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby influencing the effectiveness of cancer immunotherapies. Treatments that alter differentiation and function MDSCs can partially restore immune responses. The long noncoding RNA plasmacytoma variant translocation 1 (lncRNA Pvt1) is a potential oncogene variety types. However, whether lncRNA Pvt1 involved regulation has not been...
Myeloid‐derived suppressor cells ( MDSC s) accumulate in tumor‐bearing hosts and play a major role tumor‐induced immunosuppression, which hampers effective immuno‐therapeutic approaches. β‐Glucans have been reported to function as potent immuno‐modulators stimulate innate adaptive immune responses, contributes their antitumor property. Here, we investigated the effect of particulate β‐glucans on s found that β‐glucan treatment could promote differentiation M ‐ (monocytic into more mature CD...
Background Obesity has become a global challenge for public health. It been reported that obesity is associated with chronic inflammation. However, the mechanism inflammation contributes to remains elusive. Methodology/Principal Findings In our study, we found novel CD11c+ dendritic cell subset existed in murine adipose tissues which was immature phenotype. Moreover, as compared lean controls, number of DCs and CD4+IL-17+T cells were higher tissue high fat diet (HFD) mice. Adipose derived...
Myeloid-derived suppressor cells (MDSC) have been described in inflammatory bowel disease (IBD), but their role the remains controversial. We sought to define effect of granulocytic MDSC-derived exosomes (G-MDSC exo) dextran sulphate sodium (DSS)-induced murine colitis. G-MDSC exo-treated mice showed greater resistance colitis, as reflected by lower activity index, decreased cell infiltration damage. There was a decrease proportion Th1 and an increase regulatory T (Tregs) mesenteric lymph...
HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding that has been shown to be key regulator of myeloid cell development by targeting HOXA1. Myeloid-derived suppressor cells (MDSCs) are heterogeneous population immature possess immunosuppressive function. However, the impact HOTAIRM1 on MDSCs remains unknown. In this study, we demonstrated was expressed in and over-expression could down-regulate expression suppressive molecules MDSCs. addition, levels were...
Abstract Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands lacrimal glands. Our previous studies showed that myeloid-derived suppressor cells (MDSCs) exhibited impaired immunosuppressive function during progression patients with SS mice experimental (ESS), but it remains unclear whether restoring the of MDSCs can effectively ameliorate development ESS. In this study, we found murine olfactory...
Olfactory ecto-mesenchymal stem cells (OE-MSCs) are a novel population of resident in the olfactory lamina propria with strong immunosuppressive function. Exosomes released by MSCs considered to carry various mRNAs, microRNAs and proteins from function as an extension MSCs. However, it remains unclear whether exosomes derived OE-MSCs (OE-MSCs-Exos) possess any immunoregulatory functions. In this study, we found that OE-MSCs-Exos possessed suppressive CD4+T cell proliferation, accompanied...
Abstract Myeloid-derived suppressor cells (MDSCs) play a critical role in tumor-associated immunosuppression, thus affecting effective immunotherapies for cancers. However, the molecular mechanisms involved regulating differentiation and function of MDSCs remain largely unclear. In this study, we found that inhibition microRNA (miR)-9 promoted with significantly reduced immunosuppressive whereas overexpression miR-9 markedly enhanced MDSCs. Notably, knockdown impaired activity inhibited...
Abstract The long noncoding (lnc) RNA- Ifng-AS1 plays an essential role in the transcription of gene encoding IFN-γ by Th1 cells and its human ortholog, IFNG-AS1 , is expressed cells. However, contributing to cells’ response Hashimoto’s thyroiditis (HT) patients has not been reported. Twenty-eight HT 20 healthy controls were enrolled study. proportion circulating level T-bet, IFNG mRNA increased patients, expression was upregulated positively correlated with or T-bet expression, serum...
Abstract. Black carbon (BC) aerosol has important effects on the climate and hydrology of Tibetan Plateau (TP). An intensive measurement campaign was conducted at Lulang (∼ 3300 m a.s.l. – above sea level), southeastern TP, from September to October 2015, investigate sources physicochemical characteristics refractory BC (rBC) aerosol. The average rBC mass concentration 0.31 ± 0.55 µg m−3, which is higher than most prior results for TP. A clear diurnal cycle in showed high values morning low...
Hashimoto’s thyroiditis (HT) is an organ-specific immune disease characterized by the presence of lymphocytic infiltration and serum autoantibodies. Previous studies have confirmed critical role Th17 cells in pathopoiesis HT patients. Additionally, regulatory T (Treg) display a dysregulatory function autoimmune disease. The purpose this study to investigate alteration Treg patients explore contributing factors. We found there was increased ratio Th17/Treg positive correlation with...
Myeloid-derived suppressor cells (MDSCs) have strong immunosuppressive functions and contribute to the formation of tumor microenvironment. Long non-coding (Lnc) RNAs are highly important factors associated with tumors may be used as markers for diagnosis, which is valuable targeted therapy. LncRNA MALAT1 expressed in various tissues plays a critical role cell proliferation, including tumorigenesis metastasis. However, MDSCs unclear. In this study, we observed an increased proportion...