A5103119643- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Animal Genetics and Reproduction
- Immunodeficiency and Autoimmune Disorders
- Multiple Myeloma Research and Treatments
- Virus-based gene therapy research
- Mitochondrial Function and Pathology
- Trace Elements in Health
- CAR-T cell therapy research
- Blood Coagulation and Thrombosis Mechanisms
- Advanced Glycation End Products research
- Protein Degradation and Inhibitors
- Cardiac, Anesthesia and Surgical Outcomes
- Cytokine Signaling Pathways and Interactions
- Cardiac Ischemia and Reperfusion
- Diphtheria, Corynebacterium, and Tetanus
- PI3K/AKT/mTOR signaling in cancer
- Mycobacterium research and diagnosis
- Cardiac and Coronary Surgery Techniques
- RNA Interference and Gene Delivery
- IL-33, ST2, and ILC Pathways
Beijing Obstetrics and Gynecology Hospital
2025
Capital Medical University
2022-2025
Hebei North University
2015-2025
Beijing Chest Hospital
2024
Shandong Provincial Hospital
2023-2024
Shandong First Medical University
2023-2024
Harbin Medical University
2023
Zhejiang University
2023
Beijing Friendship Hospital
2022
Jiangsu University
2003-2022
Follicular helper T (Tfh) cells are recognized as a distinct CD4 + T-cell subset, which provides for B-cell activation and production of specific antibody responses, play critical role in the development autoimmune disease. So far, only one study investigated circulating Tfh increased subset SLE patients. Since relatively little is known about rheumatoid arthritis (RA) patients, this study, Tfh-cell frequency, related cytokine IL-21, transcription factor Bcl-6 were 53 patients with RA 31...
Follicular helper T (Tfh) cells exert an important role in the autoimmune diseases.Our study aimed to explore of Tfh patients with thyroid disease (AITD).Tfh cell is a new subset regulating antibody production B cell. Previous studies implicated CD4+CXCR5+ICOShigh or CD4+CXCR5+PD-1high as markers circulating cells. Sixty-five AITD and 30 healthy controls were enrolled current study. The percentages assessed by flow cytometry. correlation between levels autoantibodies hormones was also...
Multiple myeloma is a malignant plasma-cell disease, which highly dependent on the hypoxic bone marrow microenvironment. However, underlying mechanisms of hypoxia contributing to genesis are not fully understood. Here, we show that long non-coding RNA DARS-AS1 in directly upregulated by inducible factor (HIF)-1. Importantly, required for survival and tumorigenesis cells both vitro vivo. exerts its function binding RNA-binding motif protein 39 (RBM39), impedes interaction between RBM39 E3...
Summary Leptin modulates T cell function and plays an important role in autoimmune diseases. Our study aimed to explore the of leptin helper type 17 (Th17) cells Hashimoto’s thyroiditis patients. Twenty-seven patients with (HT) 20 healthy controls were enrolled into current study. A modest increase plasma HT CD4+ cell-derived from was stronger than that controls. In patients, there are no statistically significant correlations between concentrations percentage Th17 or level retinoic...
Rheumatoid arthritis(RA) is a common autoimmune disease associated with Th17 cells, but what about the effect of high-mobility group box chromosomal protein 1 (HMGB1) and relationship between Th17-associated factors HMGB1 in RA remains unknown. In present study, we investigated mRNA levels HMGB1, RORγt, IL-17 peripheral blood mononuclear cells (PBMCs) from patients rheumatoid arthritis by quantitative real-time PCR (RT-qPCR), concentrations IL-17, IL-23 plasma were detected ELISA. And then,...
Abstract Despite the development of promising cancer therapeutic drugs, multiple myeloma (MM) remains an incurable disease. Bufalin is a bufanolide steroid compound traditional Chinese medicine Chan Su that was previously shown to exert growth suppression effects on cell lines. Previous studies conducted by our group demonstrated bufalin activated AKT/mTOR pathway in cells, which considered essential disease progression and related drug resistance MM. In view significant role AKT MM,...
It was reported that IL-17 had been detected in the inflammatory infiltrates of patients with DM (dermatomyositis). In this study, we investigated frequency Th17 cells and expression microRNA-206 (miR-206) patients. Firstly, observed transcription factors were increased significantly PBMCs Secondly, found there a positive correlation between percentages serum level CK And concentrations IL-6, IL-1 β , TGF- IL-23, important cytokines differentiation, predicted Krüppel-like factor 4 (KLF4) is...
High-mobility group box 1 (HMGB1) is a non-histone nuclear protein that released extracellulary and has been implicated in autoimmune disease. Toll-like receptor 2 (TLR2) signalling thought to be essential for the inflammatory response immune disorders. In recent studies, enhanced HMGB1 TLR2 expressions have found rheumatoid arthritis (RA), respectively. The aim of this study explore whether stimulation can up-regulate expression on CD14(+) monocytes from patients with RA clarify subsequent...
To investigate the effects of goal-directed fluid therapy (GDFT) on volume load and hemodynamics in patients undergoing coronary artery bypass grafting (CABG). This retrospective study analyzed data from 131 with heart disease who underwent CABG between April 2020 2023. Seventy-five received GDFT were categorized as observation group, while 56 routine liquid served control group. Fluid intake outflow, load, regional cerebral oxygen saturation (rSO2), central venous blood (ScvO2), hemodynamic...
Abstract To date, few studies have specifically explored the placental transcriptome of an animal model fetal growth restriction (FGR) with nitric oxide (NO) deficiency. The aim this study was to use NG-nitro-L-arginine methyl ester (L-NAME) establish a mouse FGR NO deficiency, and explore histological changes transcriptomic complexity placenta. We established via L-NAME administration (n = 6 per group). assessed biometric phenotypes fetuses placentas, analyzed cellular morphology confirm...
Abstract Enterovirus 71 (EV71) affects the health of young children globally causing severe neurologic diseases. The relationship between EV71 infection and T helper type 17 (Th17) has not been described, although this new Th subset or interleukin‐17 (IL‐17) reported to be associated with other viral infections. purpose current study was describe immune profile involving Th17 cells, neutrophils, related factors speculate on possible immunopathogenesis Flow cytometry an automatic blood cell...
Human γδ T cells display the principal characteristics of professional antigen-presenting (APCs), in addition to playing a vital role immunity through cytokine secretion and their cytotoxic activity. However, it is not clear whether perform APC-like functions under pathological conditions. In this study, we showed that, contrast peripheral-derived directly isolated from PBMCs gastric cancer patients, tumor-activated only killed tumor efficiently but also strongly induced primary CD4 + CD8 αβ...
Proteasome inhibitor bortezomib has proven efficacy against multiple myeloma. However, activates the phosphatidylinositol 3-kinase/AKT (PI3K/AKT) pathway (which is essential to development of myeloma), often resulting in drug resistance and disease recurrence. The addition BKM120 significantly enhanced apoptotic effects both bortezomib-sensitive bortezomib-resistant cells. Treatment with alone increased phosphorylation AKT (P-AKT), whereas markedly downregulated P-AKT clinical relevance...
The outer membrane protein RagB is one of the major virulence factors periodontal pathogen Porphyromonas gingivalis (P. gingivalis). In order to induce protective immune response against P. infection, an mGITRL gene-linked ragB DNA vaccine (pIRES-ragB-mGITRL ) was constructed. Six-week-old female BALB/c mice were immunized with pIRES-ragB-mGITRL through intramuscular injection and then challenged by subcutaneous in abdomen gingivalis. RagB-specific antibody-forming cells evaluated...
Background The mammary gland is a conserved site of lipoprotein lipase expression across species and attachment to the luminal surface vascular endothelial cells has been implicated in direction circulating triglycerides into milk synthesis during lactation. Principal Findings Here we report generation transgenic mice harboring human gene driven by gland-specific promoter. Lipoprotein levels was raised 0.16 mg/ml, corresponding an activity 8772.95 mU/ml. High led significant reduction...
Background β-Glucans have been shown to function as a potent immunomodulator stimulate innate and adaptive immune responses, which contributes their anti-tumor property. However, mechanisms of action are still elusive. Glucocorticoid-induced TNF receptor ligand (GITRL), member the superfamily, binds its receptor, GITR, on both effector regulatory T cells, generates positive co-stimulatory signal implicated in wide range cell functions, is important for development responses....
Corynebacterium pyruviciproducens is a newly discovered species with no known pathogenic components such as diphtheria toxin and tuberculostearic acid, it has similar biological properties to Propionibacterium acnes, but its role of immunoregulation drawing people's attention. In this work, based on the macrophages in removal bacteria primary scavenger particulate antigen-presenting cell, stimulation by C. was analyzed through detecting levels cytokine secretion expression membrane...
Follicle-stimulating hormone (FSH) is a pituitary glycoprotein that, together with luteinizing hormone, plays crucial role in ovarian folliculogenesis and female fertility. We previously found that FSH beta major gene controlling high prolificacy of Chinese Erhualian pigs. To directly study the biological effects on reproductive function porcine (pFSH) for polyovulatory species, we generated novel gain-of-function mouse model using bacterial artificial chromosome (BAC) system to jointly...