A5101740562- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Urologic and reproductive health conditions
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Urological Disorders and Treatments
- Food composition and properties
- Circular RNAs in diseases
- Thyroid Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Neonatal Respiratory Health Research
- Sperm and Testicular Function
- RNA modifications and cancer
- Inflammasome and immune disorders
- Stress Responses and Cortisol
- S100 Proteins and Annexins
- Caveolin-1 and cellular processes
- Ubiquitin and proteasome pathways
- Neuroscience of respiration and sleep
- Reproductive System and Pregnancy
- Heme Oxygenase-1 and Carbon Monoxide
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Ovarian cancer diagnosis and treatment
- Tea Polyphenols and Effects
Affiliated Hospital of Jiangsu University
2014-2025
Jiangsu University
2014-2025
Chinese University of Hong Kong
2021-2025
Northeast Agricultural University
2024
South China Normal University
2024
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
Zhengzhou University
2024
Peking University Shenzhen Hospital
2019-2024
University of Hong Kong - Shenzhen Hospital
2019-2024
Exosomes mediate cell-cell crosstalk in cancer progression by transferring their molecular cargos, including long noncoding RNAs (lncRNAs).Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a well-known lncRNA associated with angiogenesis and metastasis.However, the presence of MALAT1 exosomes roles clinical values exosomal epithelial ovarian (EOC) remain unknown.The present study focused on between EOC cells endothelial mediated aimed to explore reveal relevance prognostic...
Abstract Background As one of the main functional forms mesenchymal stem cells (MSCs), MSC-derived extracellular vesicles (MSC-EVs) have shown an alternative therapeutic option in experimental models allergic asthma. Oxygen concentration plays important role self-renewal, proliferation, and EV release MSCs a recent study found that anti-asthma effect was enhanced by culture hypoxic conditions. However, potential EVs (Hypo-EVs) asthma is still unknown. Methods BALB/c female mice were...
Asthma is a prevalent respiratory disease, and its management remains largely unsatisfactory. Mesenchymal stem cells (MSCs) have been demonstrated to be efficacious in reducing airway inflammation experimental allergic diseases, representing potential alternative treatment for asthma. Migrasomes are recently identified extracellular vesicles (EVs) generated migrating facilitate intercellular communication. The objective of this study was investigate the therapeutic effects migrasomes...
Ischemic stroke is significantly affected by the dysfunction of miRNA network. Recent research has described that disordered expression miR-130a associated with ischemic stroke. Here, we aimed to investigate possible mechanism miR-130a-mediated neuroprotection follows ischemia-reperfusion (I/R) injury.This study was comprised two models: oxygen-glucose deprivation/Reperfusion (OGDR) and middle cerebral artery occlusion (MCAO). RT-PCR immunoblotting were used examine gene levels, MTT assay...
Abstract Background The aberrant expression of E3 ubiquitin ligase Pellino-1 (PELI1) contributes to several human cancer development and progression. However, its patterns functional importance in papillary thyroid (PTC) remains unknown. Methods PELI1 profiles PTC tissues were obtained analyzed through the starBase v3.0 analysis. Real-time PCR, Immunohistochemical assays (IHC) Western blot used investigate mRNA protein levels PTC. effects on cell progression evaluated CCK-8, colony...
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are extremely promising nanoscale cell-free therapeutic agents. We previously identified that intravenous administration (IV) of human umbilical cord MSC-EVs (hUCMSC-EVs), especially hypoxic hUCMSC-EVs (Hypo-EVs), could suppress allergic airway inflammation and remodeling. Here, we further investigated the effects Hypo-EVs by atomizing inhalation (INH), which is a non-invasive efficient drug delivery method for lung diseases....
Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disease. In recent years, increasing evidence has proven that the incidence of HT associated with excessive iodine intake body. present study, we measured status pyroptosis in tissues from patients and effects on follicular cells (TFCs), an attempt to illuminate excess development Our results showed increased occurred increase activity TFCs was primed by vitro. This process mediated reactive oxygen species (ROS) activation NF-κB...
Abstract Background Spermatogenesis is regulated by a complex network of intercellular communication processes. Extracellular vesicles (EVs) are one the important mediators in communication. Previous reports have demonstrated involvement EVs from epididymis and prostate sperm maturation function. However, presence testis their potential spermatogenesis has not been explored. Here, we established dissociation protocol that allows isolation characterization testicular EVs. Results We show...
Hashimoto's thyroiditis (HT) represents the most common organ-specific autoimmune disease. Inflammatory factors and Reactive Oxygen Species (ROS) play detrimental roles during pathogenesis of HT. In this study, we found that thyroid follicular cells (TFCs) from HT patients expressed an elevated level interleukin-23 (IL-23), which contributed to autophagy suppression ROS accumulation. Additionally, IL-23-induced accumulation in human TFCs was attributed AKT/mTOR/NF-κB signalling pathway...
Nebulization of hypoxic human umbilical cord mesenchymal stem cell-derived extracellular vesicles (Hypo-EVs) can suppress airway inflammation and remodeling in a chronic asthmatic mouse; however, the exact mechanism remains unclear. Recently, epithelial barrier defects have been regarded as crucial therapeutic targets asthma. The aim this study was to investigate whether how Hypo-EVs protect against disruption under conditions.
Abstract As the eighth most common malignant tumour worldwide, oesophageal cancer (OC) is often diagnosed during metastasis of its advanced stage. Interleukin (IL)-23 an immunomodulatory cytokine that has recently been identified as a cancer-associated factor. However, role IL-23 in evolution OC remains unclear. In present study, we found was significantly expressed tumours patients suffering and demonstrated contributed to epithelial-mesenchymal transition (EMT) through Wnt/β-catenin...
Lung cancer represents a major cause of cancer-related death worldwide. Although various tactics and anti-tumor drugs have been used to improve curative effects, five-year survival rate lung patients remains poor. In this study, we investigated the action underlying mechanisms our recently optimized Chinese herbal formula Yangyinjiedu (YYJD) against cancer. YYJD significantly inhibits proliferation cell lines (95-D, A549, H460 H1975) by inducing cycle arrest senescence in dose-dependent...
In order to clarify the effect of different fertilizers on foxtail millet quality under low nitrogen conditions, we used JGNo.21 and LZGNo.2 as experimental materials set up five treatments, including non-fertilization, nitrogen, phosphorus, compound, organic fertilizers, study regulation fertilizer types agronomic traits, nutrient fractions, pasting characteristics conditions. Compared with control, all improved traits a certain extent. Nitrogen compound treatments reduced starch content...
Human γδ T cells display the principal characteristics of professional antigen-presenting (APCs), in addition to playing a vital role immunity through cytokine secretion and their cytotoxic activity. However, it is not clear whether perform APC-like functions under pathological conditions. In this study, we showed that, contrast peripheral-derived directly isolated from PBMCs gastric cancer patients, tumor-activated only killed tumor efficiently but also strongly induced primary CD4 + CD8 αβ...
Hashimoto's thyroiditis (HT) is considered a T helper-type 1 (Th1) cytokine-dominant autoimmune thyroid disease. Caveolin-1 (Cav-1), part of the thyroxisome multiprotein complex, localized at apical pole thyrocytes and indispensable for synthesis hormones modulation oxidative stress in order to avoid cell damage apoptosis. Reduced autophagy induces follicular cells (TFC) apoptosis by activating reactive oxygen species (ROS) HT patients. Nevertheless, whether Cav-1 has roles regulation...
In the tumor microenvironment, inflammatory cells and molecules influence almost every process; among them, interleukin-23 (IL-23) is a pro-inflammatory molecule that exhibits pro- or anti-tumor properties, but both activities remain poorly understood. this study, we investigated effect of extracellular IL-23 in receptor-positive (IL-23R+) esophageal squamous cell carcinoma (ESCC) explored mechanisms underlying effect. We analyzed ESCC tissues by immunohistochemical immunofluorescence...
The nuclear division cycle 80 (NDC80) complex assures proper chromosome segregation during the cell progression. SPC25 is a crucial component of NDC80, and its role in hepatocellular carcinoma (HCC) has been explored recently. This study characterized differential expression HCC patients different races HBV infection status.Expression patterns were evaluated TCGA Chinese patients. Kaplan-Meier analysis was applied to examine predictive value SPC25. In vitro vivo functional assays conducted...