A5101614282- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- RNA modifications and cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Esophageal and GI Pathology
- Inflammatory Bowel Disease
- Metabolism, Diabetes, and Cancer
- Acute Myeloid Leukemia Research
- Biochemical and Molecular Research
- Clinical Nutrition and Gastroenterology
- Inflammasome and immune disorders
- Caveolin-1 and cellular processes
- Protein Kinase Regulation and GTPase Signaling
- Animal health and immunology
- Bacterial Genetics and Biotechnology
- Veterinary Equine Medical Research
- Amino Acid Enzymes and Metabolism
- Gout, Hyperuricemia, Uric Acid
- Hemoglobin structure and function
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
Second Affiliated Hospital of Harbin Medical University
2022
Tianjin University of Science and Technology
2022
Harbin Medical University
2022
Xi'an Chest Hospital
2020-2021
Jiangsu University
2019
Affiliated Hospital of Jiangsu University
2019
Soochow University
2016-2018
First Affiliated Hospital of Soochow University
2016-2018
Henan Provincial People's Hospital
2017
Nanjing Medical University
2014
To examine the efficiency of exclusive enteral nutrition (EEN) in relieving inflammatory bowel stricture patients with Crohn's disease (CD).Patients CD usually develop strictures due to transmural edema intestinal wall, which can potentially be managed conservative medical treatment. Previous studies showed that EEN therapy could induce clinical remission through its anti-inflammation effect.We achieved a prospective observational study. were preliminarily differentiated from fibrous one,...
Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disease. In recent years, increasing evidence has proven that the incidence of HT associated with excessive iodine intake body. present study, we measured status pyroptosis in tissues from patients and effects on follicular cells (TFCs), an attempt to illuminate excess development Our results showed increased occurred increase activity TFCs was primed by vitro. This process mediated reactive oxygen species (ROS) activation NF-κB...
miR-34, whose mimic was used on phase I clinical trial, has been extensively reported since its dysfunction in various cancers including non-small-cell lung cancer (NSCLC). However, the roles of miR-34 family members progression squamous carcinoma (SCC) patients who have occupational-exposure experience are unclear yet. Here, we comprehensively investigated expression levels SCC and compared them vitro vivo. The results showed that average miR-34a miR-34b/c were decreased patients. analysis...
The incidence of thyroid cancer has increased significantly in the last decade, and most frequent type this is papillary carcinoma. MicroRNAs have been demonstrated to be abnormally expressed tumors associated with development tumors. Our aim was analyze role molecular mechanisms tumor suppressor let-7b Expression high-mobility group A2 carcinoma tissues cell lines assessed using quantitative reverse transcription polymerase chain reaction western blot analysis. To explore or BCPAP TPC-1...
Background: Emerging evidence has revealed that miRNAs can function as oncogenes or tumor suppressor genes in leukemia. The ectopic expression of miR-130a been reported chronic leukemia, but our understanding the biological implications remains incomplete. Methods: We quantified a cohort de novo acute myeloid leukemia (AML) by bead-based miRNA and real-time quantitative PCR (Rq-PCR). luciferase reporter gene assay was analyzed after plasmid constructs which contain 5'-UTR Renilla were...
To estimate the efficacy of specific egg yolk immunoglobulin (IgY) for treatment lipopolysaccharide (LPS)-induced endotoxemia using a mouse model.Specific IgY was obtained from hens immunized with formaldehyde-killed Escherichia coli O111 and showed high binding activity to LPS when subjected an ELISA. Endotoxemia induced in mice by intraperitoneal injection at dose 20 mg kg(-1) measuring survival rate 10 cytokine measurement. The treated 200 or 5 dexamethasone 70% while none normal...
Papillary thyroid carcinoma (PTC), a common cancer (TC) subtype, rapidly increases in occurrence. MicroRNAs (miRNAs), which are non-coding small RNAs, have been demonstrated to play role pathogenic mechanisms. Although miR-143 is involved suppressing certain malignant tumor progression, its biological unknown PTC. The present study found that levels were strongly lower PTC patient samples and cell lines, implying may Down-regulation of resulted the increased expression HMGA2. Furthermore,...
TMPO-AS1, an antisense lncRNA located at human chromosome 12p23.1, has been identified as oncogene involved in cell proliferation various cancers, including LUAD. In this study, we aimed to explore the novel molecular mechanism of TMPO-AS1 underlying LUAD growth.The transcription levels miR-326, and SOX12 tissues lines were detected by quantitative real-time PCR (qRT-PCR). The ability was evaluatect 3d counting kit-8 (CCK-8) assay. Cell cycle apoptosis analysis assessed flow cytometry....
Background: Hashimoto’s thyroiditis (HT) is characterized by lymphocytic infiltration of the thyroid parenchyma, which ultimately leads to tissue destruction and loss function. Caveolin-1 (Cav-1) an essential structural constituent lipid rafts in plasma membrane cells reported be significantly reduced thyrocytes from HT patients. However, mechanism Cav-1 involvement pathogenesis still largely unclear. Methods: expression tissues patients euthyroid nodular goiter was detected...
Engineering transporter for improved efflux efficiency provides a powerful strategy to alleviate product-associated cytotoxicity and promote microbial production of desired compounds. However, the scarcity efficient transporters limits its application in construction cell factories. Here, we sought improve transport performance EamB transporter, L-cysteine exporter from Escherichia coli. A total four variants (A31V, I83M, G156A, N157M) were firstly obtained by random mutagenesis screening,...