A5046755791- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- Maternal and fetal healthcare
- Nanoplatforms for cancer theranostics
- Birth, Development, and Health
- CNS Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Maternal and Perinatal Health Interventions
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Renal and related cancers
- Ectopic Pregnancy Diagnosis and Management
- Nail Diseases and Treatments
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Glioma Diagnosis and Treatment
- Metal Extraction and Bioleaching
- Extraction and Separation Processes
- Cancer Genomics and Diagnostics
- Renal Diseases and Glomerulopathies
- Neonatal Respiratory Health Research
Beijing Obstetrics and Gynecology Hospital
2012-2025
Capital Medical University
2015-2025
Nanjing Medical University
2014-2025
Jiangsu Province Hospital
2016-2025
Sun Yat-sen University
2019-2025
Shanghai Ninth People's Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Sichuan University
2025
Central South University
2025
Beijing Children’s Hospital
2016-2024
Due to limited treatment options, pre-eclampsia (PE) is associated with fetal perinatal and maternal morbidity mortality. During the causes of PE, failure uterine spiral artery remodeling which might be related functioning abnormally trophoblast cells, result in occurrence progression PE. Recently, abnormal expression long non-coding RNAs (lncRNAs), as imperative regulators involved human diseases (included PE), has been indicated by increasing evidence. In this research, we found that TUG1,...
The success of tumor immunotherapy highlights the potential harnessing immune system to fight cancer. Activating both native T cells and exhausted is a critical step for generating effective antitumor immunity, which determined based on efficient presentation antigens co-stimulatory signals by antigen-presenting cells, as well immunosuppressive reversal. However, strategies achieving an antigen process improving microenvironment remain unresolved. Here, aggregation-induced-emission (AIE)...
Chronic kidney disease (CKD) ultimately causes renal fibrosis and end-stage disease, thus seriously threatens human health. However, current medications for CKD are inefficient, which is often due to poor targeting capability tubule. In this study, we discover that biomimetic high-density lipoprotein (bHDL) lipid nanoparticles possess excellent ability injured tubular epithelial cells by injury molecule-1(KIM-1) mediated internalization. Thus, co-load anti-inflammatory drug triptolide (TP)...
Background The great interest in cell-free mRNA, microRNA (miRNA) as molecular biomarkers for clinical applications, and 'signaling' molecules intercellular communication highlights the need to reveal their physical nature. Here this issue was explored human seminal mRNA (cfs-mRNA) miRNA (cfs-miRNA). Methodology/Principal Findings Selected male reproductive organ-specific mRNAs, miRNAs, piRNAs were quantified by quantitative real-time PCR all experiments. While stability of cfs-miRNA...
Resveratrol has been shown to be a therapeutic agent for cardiovascular disorders by maintaining lower redox level in vivo through its anti-oxidant properties. can prevent cells from p53- and reactive oxygen species-dependent apoptosis induced interleukin-1b. We identified an inhibitory effect of resveratrol against oxidative stress using the TUNEL assay NG-Nitro-l-arginine methyl ester-induced preeclampsia rats. To investigate possible association between caused vitro, assays superoxide...
Preeclampsia is a common, pregnancy-specific disease and major contributor to maternal foetal morbidity mortality. Some placental abnormalities, including deficient implantation, abnormal trophoblast cell function, improper vascular development, are believed lead preeclampsia. The long noncoding RNA SPRY4-IT1 more highly expressed in preeclamptic human placentas than normal placentas. We assessed the role of epithelial-mesenchymal transition (EMT)-associated invasion migration HTR-8/SVneo...
Abstract Despite progress in diagnostics and treatment for preeclampsia, it remains the foremost cause of maternal foetal perinatal morbidity mortality worldwide. Over recent years, various lines evidence have emphasized long non‐coding RNA s (lnc s) which function as an innovative regulator biological behaviour, exemplified by proliferation, apoptosis metastasis. However, role lnc has not been well described preeclampsia. Here, we identified a , PVT 1 whose expression was down‐regulated qRT...
The long noncoding RNA HOXA11-AS displays abnormal expression in numerous human diseases. However, its function and biological mechanisms remain unclear preeclampsia (PE). In this study, we report that is significantly downregulated preeclamptic placental tissues could contribute to the occurrence development of PE. Silencing suppress trophoblast cell growth migration, whereas overexpression facilitated HTR-8/SVneo, JEG3, JAR lines. RNA-seq analysis also indicated silencing preferentially...
Preeclampsia (PE) is a syndrome manifested by high blood pressure that could develop in the latter half of pregnancy; however, underlying mechanisms are not understood. Recent evidence points to function noncoding RNAs (ncRNAs) as novel regulators invasion, migration, proliferation, and apoptosis trophoblasts involved development placental vasculature. Here, we investigated role long intergenic ncRNA 00473 (linc00473) PE associated molecular mechanisms. The expression linc00473 was...
Abstract Immune checkpoint blockade (ICB) therapy has achieved remarkable therapeutic effects in cancer, but it is not effective glioblastoma (GBM). The main reason that difficult for drugs to penetrate blood‐brain‐barrier (BBB) GBM and lacks enough pre‐existing cytotoxic CD8 + T cells microenvironment. Here, two AIE photothermal agents (Fs Fo) are synthesized with NIR‐II fluorescence emission increase molecular twisting of by simply changing one O atom into S atom, improving Fs conversion...
We established a quick and reliable method for recovering cell-free seminal DNA (cfsDNA), by using the binding-washing-elution procedure on purification column.Low variations (below 15%) among triplicate values of cfsDNA quantity verified reproducibility our recovery method.Similar yield size distribution between plasma acquired filtration centrifugation confirmed presence cfsDNA.To investigate general characterization cfsDNA, quantitation from normozoospermic azoospermic semen were analyzed...
Ionic rare earth ore (IREO) has a high abundance of medium and heavy elements (REEs), making it vital strategic resource for China. In this work, two typical microorganisms, Aspergillus niger Acidithiobacillus ferrooxidans, were used to study the interaction mechanism during bioleaching IREO under acidic conditions. The results revealed some differences in leaching effects A. ferrooxidans on ionic minerals. mainly forms complexes with ions by secreting metabolites such as organic acids,...
Abstract To date, few studies have specifically explored the placental transcriptome of an animal model fetal growth restriction (FGR) with nitric oxide (NO) deficiency. The aim this study was to use NG-nitro-L-arginine methyl ester (L-NAME) establish a mouse FGR NO deficiency, and explore histological changes transcriptomic complexity placenta. We established via L-NAME administration (n = 6 per group). assessed biometric phenotypes fetuses placentas, analyzed cellular morphology confirm...
We recently detected cell-free seminal RNA (cfsRNA) and set out to study its concentration, integrity, stability in healthy individuals, mechanisms for protection from ribonucleases.We quantified cfsRNA by reverse-transcription quantitative real-time PCR (RT-qPCR) targeting of the 5' region ACTB (actin, beta) transcript. integrity was analyzed microcapillary electrophoresis amplification full-length DDX4 [DEAD (Asp-Glu-Ala-Asp) box polypeptide 4] transcripts, including measurement relative...
Immune checkpoint blockade (ICB) has shown promising potential for treating triple-negative breast cancer (TNBC), but its efficacy is limited, mainly due to the "cold," suppressive immune tumor microenvironment (TME). Therefore, improving TME crucial enhancing therapeutic effects against TNBC. Here, we presented a multifunctional nanotherapeutic platform (ALEvs@LNPs) designed combine cytokine-sensitized mild photothermal therapy, ICB, and interleukin-2 (IL2) mRNA therapy reprogram TME,...
In recent years, mechanical activation technology has been extensively applied as a pretreatment process to increase the leaching efficiency in hydrometallurgical mineral processing. However, studies on its application lepidolite bioleaching are limited. Therefore, effects of lithium extraction by an acidophilic iron/sulfur-oxidizing microbial community under different nutrient conditions were evaluated this study. The solution behavior, phase morphology, and compositional evolution,...
Abstract Background LncRNAs are engaged in signaling pathways human physiological and pathological states. However, mediate the onset of labor still remains unknown. Methods RNA sequencing lower segment myometrium (in vs. not labor) was analyzed. N6-Methyladenosine (m6A) complexes were detected by RIP meRIP myometrial cells. Plasmid siRNA transfection performed, contraction ability assessed. pulldown, silver staining, protein mass spectrometry used to identify binding proteins. FISH...
Preeclampsia (PE) is a hypertensive disorder that occurs during pregnancy. Low-dose aspirin used to reduce the occurrence of early-onset PE; however, mechanisms are not clear. The aim this study was reveal underlying mechanism in reducing sFlt-1-mediated apoptosis trophoblast cells PE. Serum sFlt-1 and sEng profiles placental oxidative stress levels were significantly decreased PE patients treated with compared untreated without it, whereas serum PLGF SOD increased aspirin. Aspirin...
Preeclampsia (PE) is a unique complication of pregnancy, the pathogenesis which has been generally accepted to be associated with dysfunctions extravillous trophoblast (EVT) including proliferation, apoptosis, and migration invasion. Decorin (DCN) proved decidua-derived TGF-binding proteoglycan, negatively regulates migration, invasiveness human cells. In this study, we identified higher expression level decorin in severe PE placentas by both real-time reverse transcription-polymerase chain...
Abstract Preeclampsia ( PE ), a pregnancy‐specific disorder, is associated with impaired uterine spiral artery remodelling, which related to the dysfunction of trophoblast cells. Lately, mounting evidence has indicated that aberrant expression long non‐coding RNA s (lnc s) various human diseases. The lnc MVIH transcript been shown decrease severity several However, biological function , down‐regulated in placental tissues not yet clarified. Here, we report may act as vital factor...