A5101796470- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Botanical Studies and Applications
- Photodynamic Therapy Research Studies
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Inflammasome and immune disorders
- Antioxidants, Aging, Portulaca oleracea
- Nanocluster Synthesis and Applications
- Hydrogen's biological and therapeutic effects
- Diabetes and associated disorders
- Covalent Organic Framework Applications
- Extracellular vesicles in disease
- Fungal Biology and Applications
- RNA Interference and Gene Delivery
- Biochemical effects in animals
- Nanomaterials for catalytic reactions
- Medicinal Plant Pharmacodynamics Research
- Supercapacitor Materials and Fabrication
- Concrete and Cement Materials Research
- Rock Mechanics and Modeling
- Antimicrobial Peptides and Activities
Second Affiliated Hospital of Zhejiang University
2021-2025
Zhejiang Lab
2023-2025
Blood Center of Zhejiang Province
2015-2025
Dalian Medical University
2015-2025
First Affiliated Hospital of Dalian Medical University
2015-2025
Zhejiang University
2015-2025
Zhejiang Cancer Hospital
2023-2024
Harbin Medical University
2024
University of Science and Technology Beijing
2024
Chinese Center For Disease Control and Prevention
2024
Many chemotherapeutics used for cancer treatments encounter issues during delivery to tumors in vivo and may have high levels of systemic toxicity due their nonspecific distribution. Various materials been explored fabricate nanoparticles as drug carriers improve efficiency. However, most these suffer from multiple drawbacks, such limited biocompatibility inability engineer spatially addressable surfaces that can be utilized multifunctional activity. Here, we demonstrate DNA origami...
Alzheimer's disease (AD) remains an incurable and lacks efficient diagnostic methods. Most AD treatments have focused on amyloid-β (Aβ) targeted therapy; however, it is time to consider the alternative theranostics due accumulated findings of weak correlation between Aβ deposition cognition, as well failures Phase III clinical trial therapy. Recent studies shown that tau pathway closely associated with development symptoms, which might be a potential therapeutic target. We herein construct...
Upconversion nanoparticle (UCNP)-mediated photodynamic therapy has shown great effectiveness in increasing the tissue-penetration depth of light to combat deep-seated tumors. However, inevitable phototoxicity normal tissues resulting from lack tumor selectivity remains as a major challenge. Here, development tumor-pH-sensitive nanoagents (PPNs) comprised self-assembled photosensitizers grafted pH-responsive polymeric ligands and UCNPs is reported. Under neutral pH conditions, aggregated PPNs...
Excess accumulation of mitochondrial reactive oxygen species (mtROS) is a key target for inhibiting pyroptosis-induced inflammation and tissue damage. However, targeted delivery drugs to mitochondria efficient clearance mtROS remain challenging. In current study, it discovered that polyphenols such as tannic acid (TA) can mediate the targeting polyphenol/antioxidases complexes mitochondria. This affinity does not depend on membrane potential but stems from strong binding TA outer proteins....
Response rates to conventional chemotherapeutics remain unsatisfactory for hepatocellular carcinoma (HCC) due the high of chemoresistance and recurrence. Tumor-initiating cancer stem-like cells (CSLCs) are refractory chemotherapy, their enrichment leads subsequent development To overcome stemness in HCC, we synthesized a Pt nanocluster assembly (Pt-NA) composed assembled nanoclusters incorporating pH-sensitive polymer HCC-targeting peptide. Pt-NA is latent peripheral blood, readily targets...
A self‐assembled DNA origami (DO)‐gold nanorod (GNR) complex, which is a dual‐functional nanotheranostics constructed by decorating GNRs onto the surface of origami, demonstrated. After 24 h incubation two structured DO‐GNR complexes with human MCF7 breast cancer cells, significant enhancement cell uptake achieved compared to bare two‐photon luminescence imaging. Particularly, triangle shaped complex exhibits optimal cellular accumulation. Compared GNRs, improved photothermolysis against...
Abstract Invoking the occurrence of pyroptosis is an emerging strategy for treatment cancer. However, practical applications cancer therapy are currently hindered due to lack tumor‐specific and efficient pyroptotic agents in vivo. Herein, a virus‐spike tumor‐activatable agent (VTPA) cancer‐specific reported. The VTPA composed organosilica coated iron oxide nanoparticle core spiky manganese dioxide protrusions, which can readily accumulate tumor after systemic administration, facilitate...
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy that lacks effective targeted therapies. Inducing immunogenic cell death (ICD) in tumor cells represents promising strategy to enhance therapeutic efficacy by promoting antitumor immunity. Paclitaxel (PTX), commonly used chemotherapy drug for TNBC, can induce ICD; however, the resulting immunogenicity limited. Thus, there an urgent need explore strategies improve effectiveness of ICD TNBC incorporating immunoregulatory...
A dual-membrane coating technique was developed to camouflage polypyrrole nanoparticles with red blood cells and platelet membranes for enhanced delivery photothermal tumor therapy.
Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are prevalent critical illnesses with a high mortality rate among patients in intensive care units. Neutrophil extracellular traps (NETs) implicated the pathogenesis of ALI/ARDS and represent promising therapeutic target. However, clinical application deoxyribonuclease I (DNase I), only drug currently available to clear NETs, is limited due lack precise efficient delivery strategies. Therefore, targeted DNase...
Chimeric antigen receptor T cell denoted as CAR-T therapy has realized incredible therapeutic advancements for B malignancy treatment. However, its validity yet to be successfully achieved in solid tumors. Different from hematological cancers, tumors are characterized by dysregulated blood vessels, dense extracellular matrix, and filled with immunosuppressive signals, which together result cells' insufficient infiltration rapid dysfunction. The recognition of tumor cells heterogeneity...
Many chemotherapeutics used for cancer treatments encounter issues during delivery to tumors in vivo and have high levels of systemic toxicity. One the most prominent progresses improving drug efficiency is through exploring various types nanoparticles (NPs) as carriers. Recent studies demonstrated that titanium dioxide (TiO2) nanocarriers potential therapy even multidrug resistant cancers vitro. Moreover, it was proved anticancer activity doxorubicin (DOX) enhanced by loading onto TiO2...
Background: Nitric oxide (NO) is a low-toxicity and high-efficiency anticancer treatment that can augment the cytotoxicity of doxorubicin (DOX) towards breast cancer cells, thereby exhibiting favorable effect on chemotherapy sensitization. Objective: The study aimed to establish hydrogel sensitizes by inducing local inflammatory stimulation change tumor microenvironment promote NO production. purpose was examine anti-tumor in vivo vitro. Methods: functional properties composite hydrogels...
Abstract Pyroptosis, a form of programmed cell death mediated by the gasdermin family, has emerged as promising strategy for inducing anti‐tumor immunity. However, efficiently pyroptosis in tumor cells remains significant challenge due to limited activation key mediators like caspases tissues. Herein, self‐priming pyroptosis‐inducing agent (MnNZ@OMV) is developed integrating outer membrane vesicles (OMVs) with manganese dioxide nanozymes (MnNZ) trigger cells. OMVs, derived from Escherichia...
Abstract Triple‐negative breast cancer (TNBC) is highly aggressive and insensitive to conventional targeted therapies, resulting in poor therapeutic outcomes. Recent studies have shown that abnormal iron metabolism observed TNBC, suggesting an opportunity for TNBC treatment via the iron‐dependent Fenton reaction. Nevertheless, efficiency of current reagents largely restricted by lack specificity low intracellular H 2 O level cells. Herein, core–shell–satellite nanomaces (Au @ MSN@IONP) are...