A5100650448- Air Quality and Health Impacts
- Asthma and respiratory diseases
- Dementia and Cognitive Impairment Research
- Noise Effects and Management
- Health, Environment, Cognitive Aging
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Effects and risks of endocrine disrupting chemicals
- Climate Change and Health Impacts
- RNA Research and Splicing
- Dermatology and Skin Diseases
- Genetics and Neurodevelopmental Disorders
- Inhalation and Respiratory Drug Delivery
- Autism Spectrum Disorder Research
- RNA modifications and cancer
- Heavy Metal Exposure and Toxicity
- Medical and Biological Ozone Research
- Cholinesterase and Neurodegenerative Diseases
- Extracellular vesicles in disease
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Eosinophilic Esophagitis
- Autophagy in Disease and Therapy
- Allergic Rhinitis and Sensitization
- Indoor Air Quality and Microbial Exposure
Wuhan University of Science and Technology
2018-2025
Fujian University of Traditional Chinese Medicine
2025
Qilu Hospital of Shandong University
2022-2024
Minzu University of China
2022-2023
Alzheimer’s Disease Neuroimaging Initiative
2023
Union Bank of Switzerland
2023
New York University
2017-2020
Central China Normal University
2013-2019
Zhejiang University
2017-2018
Institute of High Energy Physics
2018
Alzheimer's disease (AD) remains an incurable and lacks efficient diagnostic methods. Most AD treatments have focused on amyloid-β (Aβ) targeted therapy; however, it is time to consider the alternative theranostics due accumulated findings of weak correlation between Aβ deposition cognition, as well failures Phase III clinical trial therapy. Recent studies shown that tau pathway closely associated with development symptoms, which might be a potential therapeutic target. We herein construct...
Type 2 diabetes mellitus (T2DM) is an age-related disease characterized by impaired pancreatic β cell function and insulin resistance. Recent studies have shown that the accumulation of senescent cells under metabolic stress conditions leads to progression T2DM, while senolysis can improve prognosis. However, specific mechanism senescence still unclear. In this study, we found increased load in both older mice obese induced high-fat diet (HFD) (DIO mice) was accompanied activation Cyclic...
Abstract INTRODUCTION The prevalence and risk factors for subjective cognitive decline (SCD) its correlation with objective cognition (OCD) among community‐dwelling older adults is inconsistent. METHODS Older underwent neuropsychological clinical evaluations to reach a consensus on diagnoses. RESULTS This study included 7486 without mild impairment dementia (mean age: 71.35 years [standard deviation = 5.40]). sex‐, age‐, residence‐adjusted SCD was 58.33% overall (95% confidence interval:...
Abstract: Single-walled carbon nanotubes (SWCNTs) have shown increasing promise in the field of biomedicine, especially applications related to nervous system. However, there are limited studies available on neurotoxicity SWCNTs used vivo. In this study, neurobehavioral changes caused by mice and oxidative stress were investigated. The results ethological analysis (Morris water maze open-field test), brain histopathological examination, assessments (reactive oxygen species [ROS],...
Abstract The aggravating effects of zero-dimensional, particle-shaped nanomaterials on allergic asthma have been previously investigated, but similar possible one-dimensional shaped not reported. More importantly, there are no available means to counteract the adverse nanomaterial allow for their safe use. In this study, an ovalbumin (OVA)-sensitized rat model was established investigate whether single walled carbon nanotubes (SWCNTs) aggravate asthma. results showed that SWCNTs in rats...
Asthma is a complex pulmonary inflammatory disease characterized by the hyper-responsiveness, remodeling and inflammation of airways. Formaldehyde common indoor air pollutant that can cause asthma in people experiencing long-term exposure. The irritant effect adjuvant are two possible pathways formaldehyde promoted asthma.To explore neural mechanisms formaldehyde, 48 Balb/c mice six experimental groups were exposed to (a) vehicle control; (b) ovalbumin; (c) (3.0 mg/m(3)); (d)...
Abstract Asthma is a complex pulmonary inflammatory disease that can be promoted by air pollutants such as PM2.5 and formaldehyde (FA). However, existent experimental evidence principally focuses on the negative influence of single pollutant, neglecting possible synergistic effect in biological responses to mixture these pollutants, more common situation our daily life. In this study, allergic Balb/c mice were exposed FA, their toxicological effects mechanisms explored. It demonstrated...
Alzheimer's disease (AD) is a serious, common, global disease, yet its etiology and pathogenesis are incompletely understood. Although an association between AD exposure to air pollutants has been discussed, the effects of on functioning brain remain unclear. The indoor environment where formaldehyde (FA) can occur. Whether FA contributes development needs be investigated. To determine objective, C57BL/6 mice were exposed daily (0, 0.155, 1.55 15.5 mg/kg/day) for 1 week. After acute...
Chronic lymphocytic thyroiditis (CLT) is a common autoimmune disorder. The possible pathogenic role and mechanism of dibutyl phthalate (DBP) in CLT still controversial. Experiments were conducted after 35-days oral exposure to the three concentrations DBP or saline, immunizations with thyroglobulin (TG). Healthy female Wistar rats randomly divided into ten groups (n = 8 each): (A) saline control, (B) 0.5 mg/kg/d DBP, (C) 5 (D) 50 (E) TG-immunized group, (F) TG- combined (G) (H) (I) plus 100...
To observe the effects of electroacupuncture (EA) on anxiety-like behavior, learning and memory ability expressions myelin-related proteins in hippocampus senescence accelerated mice prone 8 (SAMP8), so as to explore mechanism EA improving Alzheimer's disease (AD) from perspective myelin sheath injury regeneration. Twenty-four male SAMP8 were randomly equally divided into model group group. Twelve SAMR1 same age used control The rats received acupuncture at "Baihui" (GV20), "Dazhui" (GV14)...
Alzheimer's disease-associated transcriptomic landscapes have been defined in brain tissue. However, changes blood RNA and their clinical relevance remain poorly understood. In this study, we developed an profile based on 1468 samples from both human mouse studies, which include bulk sequencing (RNA-seq), microRNA-seq, single-cell RNA-seq data. We a comprehensive analysis pipeline that conducted over 11 million comparisons correlations to identify more than 20,000 features. With these...
Ozone (O3) and nanoplastics (NPs) are pervasive environmental pollutants that frequently co-occur in our heavily industrialized era. While it has been documented exposure to O3 or NPs individually neurotoxic effects, studies investigating their combined impact the hazardous mechanisms resulting from co-exposure limited. In this study, we established a mouse model polystyrene nanoparticles (PS-NPs) O3, focusing on prefrontal cortex (PFC), brain region crucial for cognition emotion. We...
In the metabolic pathways associated with major biogenic amines, such as dopamine, noradrenaline, and serotonin, there exists a group of compounds known trace amines. These amines share structural similarities Since discovery amine-associated receptors (TAARs) that are activated by numerous studies have suggested these receptors, particularly TAAR1 subfamily, play role in modulating stress response involved stress-related psychiatric disorders, including depression, bipolar disorder,...
A multi-functional anti-pathogen coating with "release-killing", "contact-killing" and "anti-adhesion" properties was prepared from biocompatible polymer encapsulated chlorine dioxide (ClO2) which protected the active ingredient outside environment. slow sustained-release of ClO2 micelles over fifteen days detected for long-term release-killing. Micelles only release on demand in minimum inhibitory concentrations. We nanoparticles were covalently clustered micelle surfaces to improve...
Arsenic is a naturally occurring and highly potent metalloid known to elicit serious public health concerns. Today, approximately 200 million people around the globe are exposed arsenic-contaminated drinking water at levels greater than World Health Organization's recommended limit of 10 parts per billion. As class I human carcinogen, arsenic exposure various cancers, including lung, skin, liver, kidney. Current evidence suggests that capable inducing both genotoxic cytotoxic injury, as well...