A5043911435- Systemic Sclerosis and Related Diseases
- Dementia and Cognitive Impairment Research
- Plasmonic and Surface Plasmon Research
- Photonic and Optical Devices
- Epigenetics and DNA Methylation
- Meat and Animal Product Quality
- Network Security and Intrusion Detection
- Fish Ecology and Management Studies
- Liver Disease Diagnosis and Treatment
- Mast cells and histamine
- Optical Coatings and Gratings
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- Nutritional Studies and Diet
- Noise Effects and Management
- Heavy Metal Exposure and Toxicity
- Internet Traffic Analysis and Secure E-voting
- Fish Biology and Ecology Studies
- Trace Elements in Health
- Health, Environment, Cognitive Aging
- Gene expression and cancer classification
- Drug-Induced Hepatotoxicity and Protection
- Innovative Educational Techniques
- Electrospun Nanofibers in Biomedical Applications
- HIV/AIDS drug development and treatment
Ministry of Agriculture and Rural Affairs
2021-2025
Wuhan University of Science and Technology
2020-2025
Chengdu University of Traditional Chinese Medicine
2025
Chiba University
2024-2025
Chinese Academy of Fishery Sciences
2022-2025
China Southern Power Grid (China)
2019-2024
Chinese Academy of Agricultural Sciences
2021-2024
Institute of Food Science and Technology
2021-2024
The First Affiliated Hospital, Sun Yat-sen University
2018-2024
Zhongshan Hospital
2018-2024
The availability of cancer genomic data makes it possible to analyze genes related cancer. Cancer is usually the result a set and signal single gene could be covered by background noise. Here, we present web server named Gene Set Analysis (GSCALite) in cancers with following functional modules. (i) Differential expression tumor versus normal, survival analysis; (ii) Genomic variations their (iii) associated pathway activity; (iv) miRNA regulatory network for genes; (v) Drug sensitivity (vi)...
Abstract Cancer initiation and progression are likely caused by the dysregulation of biological pathways. Gene set analysis (GSA) could improve signal-to-noise ratio identify potential insights on gene level. However, platforms exploring cancer multi-omics data using GSA methods lacking. In this study, we upgraded our GSCALite to GSCA (gene analysis, http://bioinfo.life.hust.edu.cn/GSCA) for at genomic, pharmacogenomic immunogenomic levels. improved GSCA, integrated expression, mutation,...
Abstract Immune checkpoint genes (ICGs) play critical roles in circumventing self-reactivity and represent a novel target to develop treatments for cancers. However, comprehensive analysis the expression profile of ICGs at pan-cancer level their correlation with patient response immune blockade (ICB) based therapy is still lacking. In this study, we defined three patterns using survey RNA-seq data tumor cells from functional annotation mammalian genome (FANTOM5) project. The between patients...
A compact wavelength demultiplexing structure based on arrayed metal-insulator-metal (MIM) slot cavities is proposed and demonstrated numerically. The consists of a bus waveguide perpendicularly coupled with series cavities, each which captures SPPs at the resonance frequency from tunes transmission by changing its geometrical parameters. cavity theory model used to design operating wavelengths structure. Moreover, single band channel adjustable bandwidth can be obtained altering drop...
Cadmium (Cd) is an extremely toxic metal, capable of severely damaging several organs, including the brain. Studies have shown that Cd disrupts intracellular free calcium ([Ca2+]i) homeostasis, leading to apoptosis in a variety cells primary murine neurons. Calcium ubiquitous ion which acts as signaling mediator numerous cellular processes cell proliferation, differentiation, and survival/death. However, little known about role Cd-induced neuronal cells. Thus we investigated rat cerebral...
An ultra-compact surface plasmon polaritons (SPPs) narrow band-pass filter based on a slot cavity is proposed and numerically investigated. Attributed to the coupled resonances in cavity, demonstrates pass-band selection capability. Also, by varying positions of output waveguides, shows spectrally splitting function. Moreover, combination adjustments length/width coupling distance provides more flexibility design for locations widths pass-bands filter.
Abstract Advanced maternal age has been reported to impair oocyte quality; however, the underlying mechanisms remain be explored. In present study, we identified lowered NAD + content and decreased expression of NMNAT2 protein in oocytes from old mice. Specific depletion mouse disturbs meiotic apparatus assembly metabolic activity. Of note, nicotinic acid supplementation during vitro culture or forced aged was capable reducing reactive oxygen species (ROS) production incidence...
NAD+, nicotinamide adenine dinucleotide, is mostly described to associate with the aging process. We aimed investigate association between human whole blood NAD+ contents and in a relative large-scale community-based population further address gender impact on this association.We recruited 1,518 participants aged over 18 years old free of cardiovascular any type cancer from Jidong community 2019 2020. Whole level was measured by cycling assay LC-mass spectroscopy assay. The chronological age...
Abstract INTRODUCTION The prevalence and risk factors for subjective cognitive decline (SCD) its correlation with objective cognition (OCD) among community‐dwelling older adults is inconsistent. METHODS Older underwent neuropsychological clinical evaluations to reach a consensus on diagnoses. RESULTS This study included 7486 without mild impairment dementia (mean age: 71.35 years [standard deviation = 5.40]). sex‐, age‐, residence‐adjusted SCD was 58.33% overall (95% confidence interval:...
Abstract Traffic classification is widely used in network security and management. Early studies have mainly focused on mapping traffic to different unencrypted applications, but little research has been done of encrypted especially the underlying applications. To address above issues, this paper proposes a encryption model that combines attention mechanisms spatiotemporal features. The firstly uses long short-term memory (LSTM) method analyze continuous flows find temporal correlation...
The Yangtze River is the mother river of China. To promote aquatic ecosystem protection great river, Project Fisheries Resources and Environment Investigation (2017–2021) supported by Ministry Agriculture Rural Affairs, P. R. China carried out 24 institutes universities that located in basin surveys status (1) fish species composition spatial distribution, (2) current abundance, (3) endangered fishes, (4) finless porpoise, (5) eco-environments, (6) water-level fluctuation areas, (7) capture...
Low-voltage electrostatic fields (LVEF) are recognized as a new technology that can improve the quality of frozen meat. To determine extent to which LVEF assistance affects pork for long-term storage, was and stored at −18 −38 °C up 5 months. Water-holding capacity, muscle microstructure, protein properties were investigated after months storage with without assistance. In comparison traditional treatment inhibited water migration during thawing. As result, thawing losses reduced by 15.97%...
An active metal strip hybrid plasmonic waveguide (MSHPW) using gain materials as loss compensation is proposed with an extremely simple fabrication procedure. Gain are introduced either in the low-index layer or high-index of MSHPW. The effects dimensions and material coefficients on analyzed at communication wavelength. For one configuration presented here, a critical low 3.8cm(-1) sufficient for fully when material. MSHPW opens up opportunities practical devices applications such...
Abstract Although there has been great progress in cancer treatment, remains a serious health threat to humans because of the lack biomarkers for diagnosis, especially early-stage diagnosis. In this study, we comprehensively surveyed specifically expressed genes (SEGs) using SEGtool based on big data gene expression from The Cancer Genome Atlas (TCGA) and Genotype–Tissue Expression (GTEx) projects. 15 solid tumors, identified 233 cancer-specific SEGs (cSEGs), which were only one showed...
Non-alcoholic fatty liver disease (NAFLD) and cognitive impairment are common aging-related disorders. This study aims to explore the changes of function in middle-aged elderly population with NAFLD from a Jidong cohort.A total 1,651 participants (>40 years) without were recruited into current 2015 followed up until 2019. Abdominal ultrasonography was used for diagnosis NAFLD. Global assessed Mini-Mental State Examination (MMSE). Cognitive defined as score <18 illiterates, <21 primary school...