A5076766553- Reproductive Biology and Fertility
- Sirtuins and Resveratrol in Medicine
- Epigenetics and DNA Methylation
- Plant nutrient uptake and metabolism
- Oral Health Pathology and Treatment
- Pluripotent Stem Cells Research
- Renal and related cancers
- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Microtubule and mitosis dynamics
- Drug-Induced Hepatotoxicity and Protection
- Traditional Chinese Medicine Studies
- Lipid metabolism and biosynthesis
- Drug Transport and Resistance Mechanisms
- CAR-T cell therapy research
- Cell Adhesion Molecules Research
- Electrocatalysts for Energy Conversion
- Genetic and Kidney Cyst Diseases
- Cancer-related molecular mechanisms research
- Genetics, Aging, and Longevity in Model Organisms
- Ovarian function and disorders
- Prenatal Screening and Diagnostics
- Fuel Cells and Related Materials
- Telomeres, Telomerase, and Senescence
- Mycobacterium research and diagnosis
Hunan Agricultural University
2025
Anhui Medical University
2022-2024
Third Affiliated Hospital of Guangzhou Medical University
2020-2023
Guangzhou Medical University
2020-2023
Guangdong University of Education
2023
China Agricultural University
2022
Biocontrol (Brazil)
2022
Sun Yat-sen University
2022
First Affiliated Hospital of Anhui Medical University
2022
Nanjing Medical University
2011-2020
Abstract Advanced maternal age has been reported to impair oocyte quality; however, the underlying mechanisms remain be explored. In present study, we identified lowered NAD + content and decreased expression of NMNAT2 protein in oocytes from old mice. Specific depletion mouse disturbs meiotic apparatus assembly metabolic activity. Of note, nicotinic acid supplementation during vitro culture or forced aged was capable reducing reactive oxygen species (ROS) production incidence...
Abstract SIRT 4 modulates energy homeostasis in multiple cell types and tissues. However, its role meiotic oocytes remains unknown. Here, we report that mouse overexpressing are unable to completely progress through meiosis, showing the inadequate mitochondrial redistribution, lowered ATP content, elevated reactive oxygen species ( ROS ) level, with severely disrupted spindle/chromosome organization. Moreover, find phosphorylation of Ser293‐ PDHE 1α mediates effects overexpression on...
Plants frequently encounter relatively low and fluctuating potassium (K+) concentrations in soil, with roots serving as primary responders to this stress. Histone modifications, such de-/acetylation, can function epigenetic markers of stress-inducible genes. However, the signaling network between histone modifications low-K+ (LK) response pathways remains unclear. This study investigated regulatory role Deacetylase Complex 1 (HDC1) root growth Arabidopsis thaliana under K+ deficiency Using a...
It has been well recognized that oocyte quality declines in aging animals.However, to date, the underlying mechanism remains be explored.In present study, we report oocytes and embryos from aged mice (42-45 weeks old) display reduced expression of SIRT6 protein, accompanying with telomere shortening DNA lesions.Moreover, demonstrate specific depletion induces dysfunctional telomeres apoptosis resultant early embryos, leading developmental delay cytoplasmic fragmentation.Importantly, further...
Abstract As a highly conserved and ubiquitously expressed serine/threonine kinase, p21-activated kinase 2 (PAK2) participates in diverse biologic events. However, its roles mouse oocyte meiotic maturation remain unclear. The present study revealed that oocytes depleted of Pak2 were unable to completely progress through meiosis majority arrested at metaphase I. depletion thus prompted MI arrest induced chromosome alignment defects oocytes, part due reduction polo-like (PLK1). We demonstrated...
Objective Oral lichen planus (OLP) is a prevalent cell‐mediated autoimmune disease of unknown etiology. Disruption in the Th1/Th2 equilibrium has been suspected to contribute pathogenesis OLP. In this study, we aimed at exploring, OLP, interactions between cytokines and Golli‐MBP, regulator autogenic T cells. Subjects Methods Thirty‐six OLP patients aged 18–79 nineteen control subjects 20–69 were enrolled dental clinics Nanjing Medical University. was diagnosed clinically verified by...
Drug‑induced liver injury has become a serious public health problem. Although the mechanism of acetaminophen (APAP)‑induced been studied for decades it not fully elucidated. In‑depth study into mechanisms underlying APAP‑induced may provide useful information more effective prevention and treatment. In present study, role C‑X‑C motif chemokine ligand‑9 (CXCL9) in was investigated thus providing novel direction treatment drug hepatitis. A total 20 fasting male patients ingested APAP tablets...
Abstract Background The quality of the early embryo is vital to embryonic development and implantation. As a highly conserved serine/threonine kinase, p21-activated kinase 2 (Pak2) participates in diverse biologic processes, especially cytoskeleton remodeling cell apoptosis. In mice, Pak2 knock out endothelial depletion showed lethality. However, role preimplantation embryos remains unelucidated. Methods present work, was reduced using specific small interfering RNA mouse embryos, validating...
Hemophilia A (HA), is a X-linked recessive congenital bleeding disorder, caused by deficiency of the coagulation factor VIII (FVIII) which encoded 8 (F8). HA affects 1 every 5,000 males worldwide. The intron 22 inversion (Inv22) mutation F8 causes about 45% severe cases. Here, we generated induced pluripotent stem cells (iPSCs) from patient with Inv22 electroporation urine-derived (UCs) episomal plasmids under feeder-free, virus-free, serum-free condition and without oncogene c-MYC. This...
Plants frequently encounter relatively low and fluctuating potassium (K+) concentrations in soil, with roots serving as the primary responders to this stress. Histone modifications, such de-/acetylation, can function epigenetic marks on stress-inducible genes. However, signaling network between histone modifications K+ (LK) response pathways remains unclear. This study delves into regulatory role of Deacetylase Complex 1 (HDC1) root growth Arabidopsis thaliana under deficiency Using a hdc1-2...
Sterigmatocystin (STE) is a mycotoxin widely found in contaminated food and foodstuffs, excessive long-term exposure to STE associated with several health issues, including infertility. However, there little information available regarding the effects of toxin on female reproductive system, particularly concerning oocyte maturation. In present study, we investigated toxic mouse We also used Western blot, immunofluorescence, image quantification analyses assess impact maturation progression,...
<title>Abstract</title> As a highly conserved and ubiquitously expressed serine/threonine kinase, p21-activated kinase 2 (Pak2) participates in diverse biologic events. However, its roles mouse oocyte meiotic maturation remain unclear. The present study revealed that oocytes depleted of Pak2 were unable to completely progress through meiosis majority arrested at metaphase I. depletion thus prompted MI arrest induced apparatus assembly defects oocytes, part due reduction polo-like (Plk1). We...
Abstract Background: The quality of the early embryo is vital to embryonic development and implantation. As a highly conserved serine/threonine kinase, p21-activated kinase 2 (Pak2) participates in diverse biologic processes, especially cytoskeleton remodeling cell apoptosis. However, role Pak2 preimplantation embryos remains unelucidated. Methods: In present work, was depleted using specific small interfering RNA mouse embryos, validating unique roles spindle assembly DNA repair during mice...