A5056680045- Oral Health Pathology and Treatment
- Oral health in cancer treatment
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Salivary Gland Disorders and Functions
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Cervical Cancer and HPV Research
- Hematopoietic Stem Cell Transplantation
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and gingival health research
- Cancer Immunotherapy and Biomarkers
- HIV/AIDS oral health manifestations
- Antimicrobial Peptides and Activities
- Protease and Inhibitor Mechanisms
- Oral microbiology and periodontitis research
- Wound Healing and Treatments
- Tumors and Oncological Cases
- Autoimmune Bullous Skin Diseases
- Immunodeficiency and Autoimmune Disorders
- Bone and Joint Diseases
- Systemic Sclerosis and Related Diseases
- Infective Endocarditis Diagnosis and Management
- Vitamin D Research Studies
Harvard University
2019-2024
Brigham and Women's Hospital
2017-2024
Dana-Farber Cancer Institute
2018-2024
Dana-Farber Brigham Cancer Center
2018-2023
American Dental Education Association
2022
John Wiley & Sons (United States)
2022
University of Illinois Chicago
2008-2017
American Academy of Implant Dentistry
2015
American Academy of Arts and Sciences
2015
University of Illinois Urbana-Champaign
2008-2010
Human papillomavirus (HPV), most commonly HPV16, causes a growing subset of head and neck squamous cell carcinomas (HNSCCs), including the overwhelming majority oropharynx in many developed countries. Circulating biomarkers for HPV-positive HNSCC may allow earlier diagnosis, with potential to decrease morbidity mortality. This case-control study evaluated whether circulating tumor HPV DNA (ctHPVDNA) is detectable prediagnostic plasma from individuals later diagnosed HNSCC. Cases were...
Proliferative verrucous leukoplakia (PVL) is an aggressive oral precancerous disease characterized by a high risk of transformation to invasive squamous cell carcinoma (OSCC), and no therapies have been shown affect its natural history. A recent study the PVL immune landscape revealed cytotoxic T-cell-rich microenvironment, providing strong rationale investigate checkpoint therapy.
The aim of this study was to characterize clinical and histopathological features, management outcomes patients with oral immune-related adverse events (irAEs) secondary programmed cell death-1 (PD-1) inhibitors.This a case series cancer receiving PD-1 inhibitor therapy who were referred medicine for the development irAEs. Demographic, clinical, data collected from electronic medical records.There 13 (7 males) median age 68 years (range: 39-82) treated nivolumab (n = 7) or pembrolizumab 6)....
We evaluated the role of Toll-like receptor 4 (TLR4) in corneal epithelial wound healing.The expression TLR4 during vivo healing was examined by immunostaining mice. The and activation studied primary or telomerase-immortalized human cells (HCEC). Scratch assay performed to evaluate vitro closure using live time-lapse microscopy. Transwell migration Ki67 were done proliferation, respectively. Lipopolysaccharide (LPS) used activate TLR4, whereas CLI-095 for its inhibition. inflammatory...
The calcium-binding proteins S100A8 and S100A9 their heterocomplex calprotectin are abundant cytosolic constituents in human neutrophils, constitutively expressed by mucosal epithelium association with inflammation epidermal keratinocytes. pleiotropic proteins, which partake the regulation of leukocyte migration. This study was designed to investigate effect on neutrophil migration explore mechanisms that regulate this effect. Based previous results S100A8, we hypothesized repels neutrophils...
Accurate clinical identification of 'higher-risk' oral premalignant lesions or areas within is important. Assessment methods that predict their presence have great utility.A cross-sectional, observational study enrolled a consecutive sample consenting patients diagnosed with leukoplakia, erythroleukoplakia, erythroplakia. Medical history, visual examination, ViziLite(®) toluidine blue staining (TBlue(®) ), and finally biopsy were completed in single clinic visit. Seventy-seven 100 examined...
Abstract Objectives We aimed to assess the effectiveness of use topical imiquimod for management oral leukoplakia (OL). Methods This was a retrospective study. Medical chart reviews were conducted identify patients with biopsy‐proven OL treated 5% imiquimod. Data included characteristics, histopathological diagnosis, treatment outcome, and adverse events (AEs). Treatment response assessed by measuring percentage reduction in size lesions. Results 33 (51.5% females; median age: 65 years) 38...
While the mechanisms underlying marked sexual dimorphism in inflammatory diseases are not well understood, sexually dimorphic sympathoadrenal axis profoundly affects response. We tested whether adrenergic receptor‐mediated activation of human neutrophil function is dimorphic, since neutrophils provide first line defense There was a β 2 ‐adrenergic receptor binding, using specific ligand, [ 3 H]‐dihydroalprenolol, with almost three times more binding sites on from females (20,878±2470)...
S100A8 and S100A9 their heterocomplex calprotectin (S100A8/A9) are abundant cytosolic constituents in human neutrophils previously shown to possess antifungal activity. This study was designed investigate mechanisms involved the modulation of properties S100A8/A9. S100A8, site-directed mutants both proteins were tested for effect against Candida albicans microplate dilution assays. Whereas alone did not inhibit fungal growth, by itself had a moderate effect. Combining strongest Supporting...
Neutrophils are short-lived granulocytic cells of the innate immune system specialized in production reactive oxygen species. S100A8 and S100A9 their heterocomplex calprotectin play a role neutrophil recruitment represent 40% cytosolic protein weight. The present study was designed to test effect on rate oxidative metabolism. It is hypothesized that two S100 proteins inhibit associated oxidation. Granulocytes freshly isolated from healthy volunteers were tested for ability oxidize...
Preoperative dental screening before cardiac valve surgery is widely accepted but its required scope remains unclear. This study evaluates two preoperative (PDS) approaches, a focused approach (FocA) and comprehensive (CompA), to compare postsurgical 90-day mortality.Retrospective cohort analysis was performed on all patients who underwent at Brigham Women's Hospital with FocA Massachusetts General CompA of PDS from January 2009 December 2016. Patients intravenous drug abuse systemic...
The inflammatory response to tissue injury is a multi-faceted process. During this process, neutrophils migrate in the extravascular spaces, directed site of by chemical gradients generated chemotactic molecules. S100A8, protein associated with wide variety conditions, heavily over-expressed association inflammation. We hypothesized that human S100A8 possesses neutrophil-repelling properties result an anti-inflammatory effect vivo. activity on was tested Transwell chemotaxis assays. Analysis...