A5101762070- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Nanoparticle-Based Drug Delivery
- Cancer Genomics and Diagnostics
- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Genetic factors in colorectal cancer
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Signaling Pathways in Disease
- RNA Interference and Gene Delivery
- Breast Cancer Treatment Studies
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- ATP Synthase and ATPases Research
- Biochemical and Molecular Research
Zhejiang University
2006-2025
South China University of Technology
2023-2024
Jiujiang Maternal and Child Care Centres
2024
Zhejiang University of Technology
2024
Hainan Medical University
2015-2023
Huaian First People’s Hospital
2020-2022
Nanjing Medical University
2022
Huazhong University of Science and Technology
2022
First Hospital of China Medical University
2022
Peking Union Medical College Hospital
2022
The specific sizes that determine optimal nanoparticle tumor accumulation, penetration, and treatment remain inconclusive because many studies compared nanoparticles with multiple physicochemical variables (e.g., chemical structures, shapes, other physical properties) in addition to the size. In this study, we synthesized amphiphilic block copolymers of 7-ethyl-10-hydroxylcamptothecin (SN38) prodrug fabricated micelles ranging from 20 300 nm a single copolymer. as-prepared had exactly same...
Hexokinase-2(HK-2) plays dual roles in glucose metabolism and mediation of cell apoptosis, making it an attractive target for cancer therapy. Chrysin is a natural flavone found plant extracts which are widely used as herb medicine China. In the present study, we investigated antitumor activity chrysin against hepatocellular carcinoma (HCC) role HK-2 played to exert its function.The expression HCC line tumor tissue was examined by western blotting immunohistochemistry staining. The activities...
Methotrexate (MTX) is a first-line drug in treating psoriasis because of its strong anti-proliferation and anti-inflammatory effects. However, systemic administration MTX will lead to many side effects, such as gastrointestinal irritation, liver kidney toxicity, etc. Herein, we developed liposome-loaded microneedles (MNs) system improve transdermal efficiency, which was used overcome the problems low efficiency poor therapeutic effect traditional delivery methods. Hyaluronic acid (HA)...
Expression of the transmembrane-4-L-six-family-1 (TM4SF1) is high in human pancreatic cancer cells, but underlying mechanism remains unclear. In this study, we aimed to identify and characterize microRNAs that regulate TM4SF1 expression PC cells. Western blot analysis quantitative polymerase chain reaction were used detect hsa-miR-141 levels four cell lines. SW1990 BxPc-3 cells transfected with inhibitor miR-141, negative control, miR-141 mimic control; invasion, migration, proliferation,...
Many different treatments may affect the serum lipid profiles of breast cancer patients. This study analyzed levels at periods during treatment to observe changes in and after chemotherapy compare effects regimens on profiles. A total 805 patients were included this study. We measured who received surgery without prior operation 3, 6 12 months operation. In addition, underwent chemotherapy, last cycle chemotherapy. Lipid profile measurements cholesterol (TC), triglycerides (TG), low-density...
Circular RNAs (circRNAs) have gained attention for their involvement in carcinogenesis, but its functional effects breast cancer (BC) remains largely unclear. In this study, we aimed to explore the expressing pattern, clinical significance and potential function of a newly identified circRNA, hsa_circ_001569, BC. RT-PCR was performed detect expression hsa_circ_001569 both BC tissues cell lines. The associations between clinicopathological features prognosis patients were statistically...
CXCR4, stromal cell-derived factor-1α(SDF 1α) receptor, stimulates growth and metastasis of hepatocellular carcinoma (HCC). Alpha-fetoprotein(AFP) governs the expression some metastasis-related genes. Here we report that AFP CXCR4 levels correlated in HCC tissues. AFP-expressing vectors induced CXCR4. In agreement, depletion by siRNA decreased co-localized interacted with PTEN, thus inducing activating AKT(Ser473) phosphorylation. turn, phospho-mTOR(Ser2448) entered nucleus bound gene...
Juvenile polyposis syndrome (JPS) is a rare precancerous condition associated with high susceptibility to colorectal cancer. The genetic basis of JPS has been reported lie in germline mutations BMPR1A or SMAD4, resulting diverse clinical manifestations and an elusive underlying mechanism. We firstly utilized 139-gene next-generation sequencing (NGS) panel detect the variants further employed various prediction tools assess pathogenicity functional alternations. Consequently, we identified...
Despite consideration of benzyl isothiocyanate(BITC) is applied to prevention and therapeutic cancer, the role BITC in inducing apoptosis, inhibiting migration invasion hepatocellular carcinoma(HCC) cells still unclear. In this study, we aim explore effects on growth, HCC vitro. When human cell lines, Bel 7402 HLE, were treated with an optimal concentration for 48 hours, results indicated that inhibits growth promotes apoptosis cells; has a significant inhibitory effect cells. stimulated...
Alpha‐fetoprotein (AFP) is an early serum growth factor in the foetal liver development and hepatic carcinogenesis; However, precise biological role of cytoplasmic AFP remains elusive. Although we recently demonstrated that might interact with caspase‐3 inhibit signal transduction apoptosis human hepatocellular carcinoma (HCC) cells, details this interaction are not clear. To reveal molecular relationship between caspase‐3, performed docking, co‐immunoprecipitation (Co‐IP), laser confocal...
Abstract Hepatocellular carcinoma (HCC) cell resistance to the effects of paclitaxel has not been adequately addressed. In this study, we found that significantly inhibited viability HLE, Bel 7402 and L-02 cells in a dose- time-dependent manner. HLE resisted cytotoxicity when transfected with pcDNA3.1- afp vectors. However, sensitivity was increased alpha fetoprotein (AFP)-siRNA. associated expression “stemness” markers CD44 CD133. Paclitaxel growth promoted apoptosis by inducing...
Gastric cancer (GC) is one of the main causes high death rate in world. But molecular mechanisms GC carcinogenesis remain little known. This study aimed to identify novel promising biomarkers and reveal its potential by integrating bioinformatics analysis. We screened overlapped differentially expressed genes (DEGs) TCGA several GEO datasets. Among these DEGs, we used protein-protein interactions network analysis recognize hub genes. Moreover, functional enrichment including GO KEGG pathway...
Background: Transmembrane-4-L-six-family-1 (TM4SF1) functions to regulate cell growth and mobility TM4SF1 expression was upregulated in pancreatic cancer. This study further investigated the role of regulating cancer epithelial-mesenchymal transition (EMT) angiogenesis underlying molecular events.Methods: Tissue specimens were collected from 90 patients for immunohistochemical qRT-PCR analysis miR-141 levels, respectively. Pancreatic lines used vitro assays, while nude mice vivo...
Abstract Nowadays, research on CSCs is still in an initial stage, and there are few studies reporting the successful isolation identification of CSCs. In present study, we attempted to isolate through cultivating cell line MKN45 defined serum‐free medium study expression stem markers or related proteins (Oct3/4, Sox2, Nanog CD44) Moreover, immunofluorescence staining was performed validate spheroid body‐forming cells. Further experiments were used evaluate SPOP tumorsphere addition,...
Gastric cancer (GC) is a globally prevalent cancer, ranking fifth for incidence and fourth mortality worldwide. The N6-methyladenosine (m6A) related long noncoding RNAs (lncRNAs) were widely investigated in recent studies. Nevertheless, the underlying prognostic implication tumor immune mechanism of m6A-related lncRNA GC remain unknown.We systematically assessed m6A modification expression 407 clinical samples based on 23 regulators comprehensively associated these genes with lncRNAs. Then,...
Histone methyltransferase DOT1L is implicated in various biological processes including cell proliferation, differentiation and embryogenesis. Gene ablation of Dot1l results embryonic lethality cardiovascular defects decreased vasculature. However, how might contribute to the development vasculature not clear. Here, we report that required for angiogenesis. We demonstrated silencing human umbilical vein endothelial cells (HUVECs) leads viability, migration, tube formation, capillary sprout...
Background: Although it is widely accepted that invasive micropapillary carcinoma (IMPC) presents more aggressive behavior and has a higher behavior, the prognosis of IMPC compared with ductal (IDC) remains controversial.We conducted this study to explore gene expression profiles establish competing nomogram predicts survival outcomes across these two groups patients.Methods: Data from Surveillance, Epidemiology, End Results (SEER) database were reviewed.Propensity score matching (PSM) was...