A5091680687- RNA modifications and cancer
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Curcumin's Biomedical Applications
- Lung Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Gastrointestinal Tumor Research and Treatment
- Extracellular vesicles in disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Monoclonal and Polyclonal Antibodies Research
- Traditional Chinese Medicine Analysis
- Signaling Pathways in Disease
- Chronic Lymphocytic Leukemia Research
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Pharmacological Effects of Medicinal Plants
Yancheng First People's Hospital
2015-2025
Nantong University
2016-2025
Xuzhou Medical College
2024-2025
Twelfth Guangzhou City People's Hospital
2024
Beijing Chao-Yang Hospital
2024
Capital Medical University
2024
Affiliated Hospital of Nantong University
2016-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2022
Peking Union Medical College Hospital
2022
Zhoushan Hospital
2018
Tumor-associated macrophages (TAM) are critical elements of intercellular communication in tumor microenvironment (TME), and exosomes key mediators between cells the TME. According to previous reports, miRNAs exert a pivotal role ovarian cancer (OC) development. The purpose this work was explore function TAM-derived exosomal miR-589-3p OC development elucidate underlying molecular mechanisms. First, peripheral blood mononuclear (PBMC) were treated with IL-4 IL-13 polarize them into M2-type...
Cryptotanshinone (CTS), a bioactive constituent extracted from Chinese traditional herb Danshen (Salvia miltiorrhiza), demonstrates multiple protective effects against cardiovascular diseases. The present study was designed to explore the of CTS in vitro by cultured adult rat cardiac fibroblasts stimulated with angiotensin II (Ang II) and vivo rats acute myocardial infarction. Our data showed that fibroblasts, attenuated Ang II-induced upregulation fibronectin, connective tissue growth...
Objective Periarticular and subchondral bone erosion in rheumatoid arthritis caused by osteoclast differentiation activation is a critical index for diagnosis, therapy monitoring of the disease. Sorting nexin (SNX) 10, member SNX family which functions regulation endosomal sorting, has been implicated to play an important clinical role malignant osteopetrosis. Here we studied roles precise mechanisms SNX10 destruction collagen-induced (CIA) mice. Methods The was evaluated CIA mice model...
FOSB protein is encoded by the gene in humans, which shares structural similarities with prototype of Fos family. plays a role AP-1 complex composed heterodimers Jun and members. Our experiment aimed to evaluate effect gastric cancer (GC) patients then probe its significance prognosis. We detected expression GC adjacent non-cancerous tissues western blot analysis real-time quantitative PCR (qRT-PCR). Moreover, we analyzed who underwent resection procedures using immunohistochemistry. The...
Cancer metastasis is the major reason for cancer related deaths, and mechanism of still unclear. RPLP1, a member group proteins known as ribosomal proteins, associated with tumorigenesis primary cell immortalization involved in cellular transformation. However, expression potential function RPLP1 TNBC remain unclear.The tissues lines were detected Real-Time PCR western blotting. 81 cases tissue samples adjacent non-tumor tested by immunochemistry to determine correlation between...
Six new sesquiterpenoids, aristoyunnolins A–F (1–6), an artifact of isolation [7-O-ethyl madolin W (7)], and 12 known analogues were isolated from stems Aristolochia yunnanensis. The structures determined by combined chemical spectral methods, the absolute configurations compounds 2, 3, 5–7, 9, 14, 17 modified Mosher's method CD analysis. Compounds 1–19 screened using a bioassay system designed to evaluate effect on mitogen-activated protein kinases (MAPKs) signaling pathways. Among three...
As the prevalence of obesity increases, so does occurrence obesity-related complications, such as cardiovascular and cerebrovascular diseases, diabetes, some cancers. Increased adipose tissue is main cause harm in obesity. To better understand its related we analyzed mRNA expression profiles tissues from 126 patients with 275 non-obese controls. Using an integrated bioinformatics method, explored functions 113 differentially expressed genes (DEGs) between them. Gene ontology (GO) kyoto...
Given the emerging role of microRNAs (miRs) in cancer progression, present study investigated and underlying mechanism miR‑103 colorectal (CRC). Reverse transcription‑quantitative polymerase chain reaction was conducted to quantify expression levels clinical specimens cell lines. The CRC examined using MTT, colony formation transwell assays. In addition, a luciferase reporter assay used confirm an associated between 3' untranslated region zonula occuldens‑1 (ZO‑1) miR‑103. results...
The melanoma-associated antigen (MAGE) genes are commonly expressed in tumors, but the function of many these remains unknown. Here, we investigated expression one family member, MAGE-A11, breast cancer tissues and corresponding adjacent normal tissues. MAGE-A11 was assessed from 100 women by immunohistochemistry. significantly more highly tumors (56% samples) compared to (0%; P<0.05). Additionally, its relation various clinicopathological features, including patient age, tumor stage volume,...
Two new sesquiterpenoids, namely elema-1,3,7(11),8-tetraen-8,12-lactam (1) and 7β,8α-dihydroxy-1α,4αH-guai-9,11-dien-5β,8β-endoxide (2), together with five known analogs were isolated from the EtOAc extract of rhizomes Curcuma wenyujin. Their structures relative configurations determined on basis spectroscopic methods including 2D-NMR techniques. All compounds tested for inhibition lipopolysaccharide (LPS)-induced nitric oxide (NO) production. Compound 1 showed significant inhibitory...
Abstract: The aim of this study was to investigate the calcyphosine (CAPS) expression in human colorectal cancer (CRC) and explore its clinical prognostic significances. CAPS measured by Western blot, real-time polymerase chain reaction analysis, immunohistochemistry. relationships between levels clinicopathological factors were investigated. Kaplan–Meier method log-rank test used overall survival patients. Moreover, effects on biological roles CRC cells also evaluated MTT assay, colony...
Radiofrequency ablation (RFA) is an effective treatment option for hepatocellular carcinoma (HCC). This study aimed to analyze the prognostic factors of HCC patients treated with RFA and develop nomograms outcome prediction.A total 3142 were recruited, their data collected from Surveillance, Epidemiology, End Results database. Univariate multifactor Cox analyses performed identify independent factors. These integrated into a nomogram predict 3- 5-year cancer-specific survival (CSS) overall...
Background: Lymph node (LN) metastasis is considered one of the most important risk factors affecting prognosis distal cholangiocarcinoma (DCC). This study aimed to demonstrate superiority log odds positive lymph nodes (LODDS) compared with other LN stages, and establish a novel prognostic nomogram predict cancer-specific survival (CSS) DCC. Methods: From Surveillance, Epidemiology End Results (SEER) database, data 676 patients after DCC radical operation were screened, randomly divided into...