A5009848496- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Fungal Biology and Applications
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Chemical synthesis and alkaloids
- Traditional and Medicinal Uses of Annonaceae
- Cholinesterase and Neurodegenerative Diseases
- Phosphodiesterase function and regulation
- Sesquiterpenes and Asteraceae Studies
- Toxin Mechanisms and Immunotoxins
- Drug-Induced Hepatotoxicity and Protection
- Crystallography and molecular interactions
- Pharmacological Effects of Natural Compounds
- Plant Pathogens and Fungal Diseases
- Synthesis of Organic Compounds
- Bioactive Natural Diterpenoids Research
- Synthesis and Biological Activity
- Nephrotoxicity and Medicinal Plants
- Biological Activity of Diterpenoids and Biflavonoids
- Visual perception and processing mechanisms
- Herbal Medicine Research Studies
Hainan University
2023-2025
Henan University
2017-2022
Peking University
2016-2019
58.com (China)
2019
State Council of the People's Republic of China
2018
Beijing Jiaotong University
2018
Sun Yat-sen University
2011-2017
State Key Laboratory of Natural and Biomimetic Drugs
2017
Bioassay-guided fractionation of the ethanolic extract roots Toddalia asiatica led to isolation seven new prenylated coumarins (1–7) and 14 known analogues (8–21). The structures 1–7 were elucidated by spectroscopic analysis, their absolute configurations determined combined chemical methods chiral separation analysis. Compounds 1–5, named toddalin A, 3‴-O-demethyltoddalin toddalins B–D, represent an unusual group phenylpropenoic acid-coupled coumarins. 1–21 four modified analogues, 10a,...
Eleven fumiquinazoline-type alkaloids, namely, versiquinazolines A–K (1–11), along with cottoquinazolines B–D, were isolated from the gorgonian-derived fungus Aspergillus versicolor LZD-14-1. Their structures determined by extensive analyses of spectroscopic data (1D and 2D NMR, HRESIMS), in addition to experimental calculated ECD X-ray single-crystal diffraction analysis for assignments absolute configurations. Versiquinazolines A, B, F (1, 2, 6), bearing a methanediamine or an...
Seven new phenolic bisabolane sesquiterpenoids (1–7), along with 10 biogenetically related analogues (8–17), were obtained from the deep-sea-derived fungus Aspergillus versicolor YPH93. The structures elucidated based on extensive analyses of spectroscopic data. Compounds 1–3 are first examples bisabolanes that contain two hydroxy groups attached to pyran ring. sydowic acid derivatives (1–6 and 8–10) carefully studied, leading structure revisions six known analogues, including a revision...
Ten new ergone derivatives (
Chemical examination of an EtOAc extract a cultured Acremonium sp. fungus from deep-sea sediments resulted in the isolation 15 new eremophilane-type sesquiterpenoids, namely, acremeremophilanes A–O (1–15), together with seven known analogues. The structures compounds were determined through extensive spectroscopic analyses, association chemical conversions and ECD calculations for configurational assignments. PKS-derived 4-hexenoic acid unit 2–6 is rarely found nature. All evaluated...
Abstract Bioassay-guided fractionation of the ethanolic extract leaves Psidium guajava led to isolation 11 new meroterpenoids, psiguajadials A–K ( 1 – ), along with 17 known ones 12 28 ). Their structures and absolute configurations were elucidated by spectroscopic methods comparison experimental calculated ECD. Compounds 2 represent two unprecedented skeletons 3,5-diformyl-benzyl phloroglucinol-coupled sesquiterpenoid, while 3 is first example meroterpenoids coupling via an oxepane ring....
Two heterodimeric diterpenoids (1 and 2) comprising abietane lactone nor-rosane constituent units were isolated from Euphorbia ebracteolata roots. Compound 1 exhibited a moderate inhibitory effect on α-glucosidase (IC50 = 7.94 μM), with Ki value of 10.8 μM. In silico molecular docking has been performed to investigate the inhibition mechanism. 2 inhibited acetyl transfer activity Mycobacterium tuberculosis GlmU 41.85 which is novel treatment target.
Three novel asteltoxin-bearing dimers namely diasteltoxins A-C (1-3) along with asteltoxin were isolated from a mutated strain of sponge-derived fungus Emericella variecolor XSA-07-2. Their structures determined by extensive spectroscopic analyses including the computed electronic circular dichroism (ECD) data for configurational assignment. The biogenetic formation through [2 + 2] cycloaddition was postulated. Diasteltoxins 1-3 exerted inhibitory effects against tumor cell lines H1299 and...
Bioassay-guided fractionation of the ethanolic extract stems Aristolochia fordiana led to isolation six new dihydrobenzofuran neolignans (1–3 and 7–9), three 2-aryldihydrobenzofurans (4–6), a 8-O-4′ neolignan (10), 14 known analogues (11–24). The structures compounds 1–10 were established by spectroscopic methods, their absolute configurations determined analyses specific rotation electronic circular dichroism data. neuroprotective effects 1–24 against glutamate-induced cell death tested in...
Bioassay-guided fractionation of a sponge associated fungus<italic>Stachybotrys chartarum</italic>resulted in the isolation 15 trichothecene-based sesquiterpenes with inhibitory effects against tumor cell lines.
Versicotides D–F, new cyclopeptides were isolated from a gorgonian-derived fungus<italic>Aspergillus versicolor</italic>LZD-14-1 and showed lipid-lowering effects.
Ten new prostaglandin derivatives (PGs), sarcoehrendins A–J (1–10), together with five known analogues (11–15) were isolated from the soft coral Sarcophyton ehrenbergi. Compounds 4–8 represented first examples of PGs featuring an 18-ketone group. The structures including absolute configurations elucidated on basis spectroscopic analysis and chemical evidence. All isolates six synthetic (3a, 3b, 4a, 11a–11c) screened for inhibitory activity against phosphodiesterase-4 (PDE4), which is a drug...
A new indole diterpene, named penicindopene (1), together with seven known compounds (2 – 8), was isolated from the deep-sea fungus Penicillium sp. YPCMAC1. The structure of elucidated by extensive spectroscopic analyses (1 D and 2 NMR, HRESIMS data), in addition to ECD calculations for assignments its absolute configuration. Penicindopene represented first example diterpenes possessing a 3-hydroxyl-2-indolone moiety, it exhibited moderate cytotoxicities against A549 HeLa cell lines IC50...
Background: Chemotherapy resistance is a barrier to effective cancer prognoses.Cisplatin (CDDP) major challenge for esophageal (EC) therapy.A deeper understanding of the fundamental mechanisms cisplatin and improved targeting strategies are required in clinical settings.This study was performed identify characterize marker EC cells.Method: KYSE140 Eca-109 cells were subjected escalating concentrations cisplatin, resulting development cisplatin-resistant KYSE140/CDDP Eca-109/CDDP cell lines,...
Six new sesquiterpenoids, including one with a skeleton, and 24 known analogues were isolated from<italic>Aristolochia mollissima</italic>.
Chemical examination of the EtOAc extract deep sea-derived fungus Penicillium sp. YPGA11 resulted in isolation four new farnesylcyclohexenones, peniginsengins B⁻E (1⁻4), and a known analog peniginsengin A (5). The structures compounds 1⁻4 were determined on basis comprehensive analyses nuclear magnetic resonance (NMR) mass spectroscopy (MS) data, absolute configurations 1, 2, 4 by comparisons experimental electronic circular dichroism (ECD) with calculated ECD spectra. Compounds 1⁻5,...
Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of deep sea-derived fungus Aspergillus terreus YPGA10. The structures compounds 1-3 determined on basis comprehensive analyses nuclear magnetic resonance (NMR) and mass spectroscopy (MS) data, absolute configurations 1 2 by comparisons experimental electronic circular dichroism (ECD) calculated ECD spectra. Compound represents rare...