A5005820972- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Bioactive Natural Diterpenoids Research
- Fungal Biology and Applications
- Plant biochemistry and biosynthesis
- Traditional and Medicinal Uses of Annonaceae
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Pharmacogenetics and Drug Metabolism
- Intermetallics and Advanced Alloy Properties
- Phytochemistry and Bioactive Compounds
- Bioactive natural compounds
- Advanced materials and composites
- Metallurgical Processes and Thermodynamics
- Advanced ceramic materials synthesis
- Alkaloids: synthesis and pharmacology
- MXene and MAX Phase Materials
- Pharmacological Effects of Medicinal Plants
- Computational Drug Discovery Methods
- Plant-based Medicinal Research
- Phytochemical Studies and Bioactivities
- Drug Transport and Resistance Mechanisms
- Sesquiterpenes and Asteraceae Studies
- Steroid Chemistry and Biochemistry
China University of Mining and Technology
2022-2025
Dalian Medical University
2015-2024
Second Affiliated Hospital of Dalian Medical University
2016-2024
Zhejiang Normal University
2024
First Affiliated Hospital of Dalian Medical University
2017-2024
Northeastern University
2017-2022
Dalian University
2008-2021
Dalian Ocean University
2018-2021
Ministry of Agriculture and Rural Affairs
2021
Inner Mongolia University
2020-2021
Andrographolide (Andro), a diterpenoid lactone, has been used for treatment of various cancers with less adverse effects. However, the underlying mechanisms regarding its anti-tumor mechanism still remain unclear.Cell viability and proliferation were measured by CCK8 CFSE dilution assay. The localization p50/p65 or cytochrome c was determined using confocal immunofluorescence. Streptavidin-agarose pulldown ChIP assays to detect binding multiple transactivators COX-2 promoter. promoter...
Gamabufotalin (CS-6), a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic stability and less adverse effect. However, the underlying mechanism CS-6 involved in anti-tumor activity remains poorly understood.The biological functions gamabufotalin (CS-6) were investigated by migration, colony formation apoptosis assays NSCLC cells. The nuclear localization interaction between transcriptional co-activator p300 NF-κB p50/p65 their binding COX-2...
Twelve new and 10 known protostane triterpenoids were isolated from the rhizome of Alisma orientale. Their structures elucidated based on physical data analyses, including UV, HRESIMS, NMR experiments (1H, 13C NMR, 1H–1H COSY, HSQC, HMBC, NOESY), induced electronic circular dichroism. New compounds 1–12 classified as protostanes (1–10), 29-norprotostane (11), 24-norprotostane (12) by structure analyses. Furthermore, inhibitory effects human carboxylesterases (hCE-1, hCE-2) 1–22 evaluated....
β-Glucuronidase (GLU) is an important biomarker for primary cancers and intestinal metabolism of drugs or endogenous substances; however, effective optical probe near-infrared (NIR) monitoring in vivo still lacking. Herein, we design enzyme-activated off-on NIR fluorescent probe, HC-glu, based on a hemicyanine keleton, which conjugated with d-glucuronic acid residue via glycosidic bond, the quantification trapping GLU activity vitro vivo. The newly developed exhibited prominent features...
Inhibition of ferroptosis in intestinal epithelial cells ameliorates clinical symptoms and improves endoscopic presentations inflammatory bowel disease (IBD). Licorice is used worldwide food medicine fields. Liquiritin, a flavonoid component licorice, an effective substance as anti-inflammatory, antioxidant that has been shown to improve chemically induced colitis. Herein we evaluated the therapeutic effects liquiritin on colitis determined whether could affect by modulating cells. A model...
Objective Dysbiosis of the intestinal fungal community has been observed in inflammatory bowel disease (IBD); however, its potential role IBD development and prevention remains unclear. Here, we explored biological effects molecular mechanisms fungi isolated from human faeces on colitis mice. Design Intestinal strains with differential abundance were cultivated their various mouse models experimental evaluated. In addition, bioactive metabolites secreted by target fungus accurately...
Abstract Background Glioblastoma multiforme (GBM) is one of the most refractory and palindromic central nervous system (CNS) neoplasms, current treatments have poor effects in GBM patients. Hence, identification novel therapeutic targets development effective treatment strategies are essential. Alantolactone (ATL) has a wide range pharmacological activities, its anti-tumor effect receiving increasing attention. However, molecular mechanism underlying anti-GBM activity ATL remains poorly...
Twelve new highly oxygenated lanostane triterpenoids and nine known ganoderic acids were isolated from the fruiting body of Ganoderma lucidum. The compounds nortriterpenoids with 27 carbons (1–5 8), nor-triterpenoids 25 (6 7), (9–12) based on multiple spectroscopic data analysis, including HRESIMS, 1D-NMR, 2D-NMR, CD. Compounds 1–5 identified as rare nor-lanostanoids that contain a 17β-pentatomic lactone ring. Compound 13, possessing ring, had been previously. P-glycoprotein (P-gp)...
Carboxylesterase 2 (CES 2) is a key enzyme in the activation of prodrug irinotecan (CPT-11) treatment against colorectal cancer and also has some relationship with side effect CPT-11 clinical applications.
Vanin-1 is an amidohydrolase that catalyses the conversion of pantetheine into amino-thiol cysteamine and pantothenic acid (coenzyme A precursor), which plays a vital role in multiple physiological pathological processes. In this study, enzyme-activated near-infrared (NIR) fluorescent probe (DDAV) has been constructed for sensitively detecting activity complicated biosamples on basis its catalytic characteristics. DDAV exhibited high selectivity sensitivity toward was successfully applied to...
Abstract To enhance the oxidation resistance of HfB 2 ‐SiC‐ZrSi coating, low‐loss film‐forming treatment (LFT) was employed to generate high‐quality oxygen barrier glass layers, and modification effect varying formation temperature on investigated at 1700°C. The results demonstrated that, with LFT 1500°C, relatively modest activity complete dispersion metal oxide nanocrystals generated a compact continuous composite layer, which caused decreased excessive might result in oxidized porous...