A5100732037- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Ferroptosis and cancer prognosis
- Advanced Image Fusion Techniques
- Cancer, Hypoxia, and Metabolism
- Flavonoids in Medical Research
- Toxin Mechanisms and Immunotoxins
- Immune cells in cancer
- Pharmacological Effects of Natural Compounds
- Infrared Target Detection Methodologies
- Genomics, phytochemicals, and oxidative stress
- Cancer, Lipids, and Metabolism
- Pregnancy and preeclampsia studies
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Advanced Glycation End Products research
- Alkaloids: synthesis and pharmacology
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Phytochemistry and Biological Activities
- Sphingolipid Metabolism and Signaling
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Nanoplatforms for cancer theranostics
- Berberine and alkaloids research
Nanjing University of Chinese Medicine
2013-2025
Shenyang Aerospace University
2021-2024
Central South University
2024
Dalian Medical University
2017-2023
The Synergetic Innovation Center for Advanced Materials
2022-2023
Tianjin Huanhu Hospital
2023
Integrated Chinese Medicine (China)
2022
Anhui Agricultural University
2022
Shenyang Pharmaceutical University
2022
Space Engineering University
2022
Significance Stress cannot be avoided in the present competitive world, and chronic stress is associated with detrimental effects on physical health, including progression of inflammatory bowel disease (IBD). However, mechanisms behind it are less clearly understood. This study showed that disturbed gut microbiota, thereby triggering immune system response facilitating dextran sulfate sodium-induced colitis. Results also stress-deficient expression mucin-2 lysozyme, which may contribute to...
In situ oxygen generation is the most common strategy to boost reactive species (ROS) for enhancing efficacy of phototherapy in cancer, including photodynamic therapy (PDT) and photothermal (PTT). However, hyperoxidation or hyperthermia often triggers stress-defense pathways promotes tumor cell survival, thus severely limiting therapeutic efficacy. To overcome hypoxia thermal resistance existing phototherapy, we constructed a self-synergistic nanoplatform tumors by incorporating brusatol,...
Andrographolide (Andro), a diterpenoid lactone, has been used for treatment of various cancers with less adverse effects. However, the underlying mechanisms regarding its anti-tumor mechanism still remain unclear.Cell viability and proliferation were measured by CCK8 CFSE dilution assay. The localization p50/p65 or cytochrome c was determined using confocal immunofluorescence. Streptavidin-agarose pulldown ChIP assays to detect binding multiple transactivators COX-2 promoter. promoter...
Background The loss of tumor antigens and depletion CD8 T cells caused by the PD-1/PD-L1 pathway are important factors for immune escape. In recent years, there has been increasing research on traditional Chinese medicine in treatment. Cycloastragenol (CAG), an effective active molecule Astragalus membranaceus , found to have antiviral, anti-aging, anti-inflammatory, other functions. However, its antitumor effect mechanism not clear. Methods CAG was investigated MC38 CT26 mouse transplanted...
Abstract Colorectal cancer (CRC) usually creates an immunosuppressive microenvironment, thereby hindering immunotherapy response. Effective treatment options remain elusive. Using scRNA‐seq analysis in a tumor‐bearing murine model, it is found that lobeline, alkaloid from the herbal medicine lobelia, promotes polarization of tumor‐associated macrophages (TAMs) toward M1‐like TAMs while inhibiting their M2‐like TAMs. Additionally, lobeline upregulates mRNA expression secreted...
Diabetes Mellitus (DM) is widely acknowledged to increase the risk of cardiovascular death, which warrants use aggressive primary prevention strategies. The aim present study was investigate pretreatment effects tanshinone IIA (TSN), a traditional Chinese medicine, on myocardial infarct size, apoptosis, inflammation and cardiac functional recovery in diabetic rats subjected ischaemia/reperfusion (I/R).Streptozocin (STZ) induced (n = 80) were randomized receive TSN, TSN plus wortmannin [a...
Abstract The purpose of the present study was to evaluate anti‐cancer property Lobetyolin on colorectal cancer and explore its potential mechanism. incubated with HCT‐116 cells in absence or presence ASCT2 inhibitor Benser p53 Pifithrin‐α. levels glutamine, glutamic acid, α‐ketoglutarate, ATP GSH were determined measure glutamine metabolism. Annexin V‐FITC/PI staining TUNEL assay applied estimate apoptotic condition. examined by RT‐qPCR, Western blot immunofluorescence staining. expressions...
Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. Although SHP2 is hopeful target for therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing was performed to explore the role in all cell types microenvironment (TME) from murine MC38 xenografts. Intratumoral cells were found be functionally heterogeneous responded significantly SHP099, allosteric...
Abstract Background Non‐apoptotic cell death is presently emerging as a potential direction to overcome the apoptosis resistance of cancer cells. In current study, natural plant agent α‐hederin (α‐hed) induces caspase‐independent paraptotic modes death. Purpose The present study aimed investigate role α‐hed paraptosis and associated mechanism it. Methods proliferation was detected by CCK‐8. cytoplasm organelles were observed under electron microscope. Calcium (Ca 2+ ) level flow cytometry....
Abstract Background Glioblastoma multiforme (GBM) is one of the most refractory and palindromic central nervous system (CNS) neoplasms, current treatments have poor effects in GBM patients. Hence, identification novel therapeutic targets development effective treatment strategies are essential. Alantolactone (ATL) has a wide range pharmacological activities, its anti-tumor effect receiving increasing attention. However, molecular mechanism underlying anti-GBM activity ATL remains poorly...
Exosomes are extracellular vesicles secreted by most cells to deliver functional cargoes recipient cells. MicroRNAs (miRNAs) constitute a significant part of exosomal contents. The ease diffusion exosomes renders them speedy and highly efficient vehicles molecules. Cancer secrete more than normal Reports have showed that miRNAs cancer facilitate progression. Yet the complexity dictates many remain be discovered.In this study, we analyzed miRNA expression profiles tissue plasma exosome...
Bone marrow mesenchymal stem cells (BMSCs) tissue engineering has been an emerging field of research in recent years. Given the increasing global interest, we utilized a bibliometric analysis and visualization studies on BMSCs published from 2004 to 2023 explore progress identify future directions. Data was collected Web Science Core Collection (WoSCC), in-depth conducted using various tools, including CiteSpace, VOSviewer, R-Bibliometrix. Our study revealed historical development evolution...
<title>Abstract</title> In response to the challenge of insufficient target detection accuracy for UAVs in adverse environments(such as low light, dense fog, and extreme weather), this paper proposes a lightweight multi-modalfusion network, MMT-NET, UAV such conditions. The network significantlyimproves performance complex environments by fusing complementary characteristicsof infrared visible light images, combined with design. MMT-NET is based on RT-DETR framework uses MobileNetV4 backbone...
Curcumin, a natural polyphenolic compound, has commonly been used as food additive or in many traditional medicine remedies for over 2,000 years Asian countries. Melatonin is hormone secreted from pineal glands of mammals and possesses diverse physiological functions. Both curcumin melatonin have the effective potential to inhibit proliferation various types cancers, but there no report on their combination bladder cancer treatment, underlying mechanism remains poorly understood. In present...
Abstract Background Some natural compounds inhibit cancer cell growth in various lines with fewer side effects than traditional chemotherapy. Here, we explore the pharmacological and mechanisms of worenine (isolated from Coptis chinensis ) against colorectal cancer. Methods The on proliferation, colony formation cycle distribution were measured. Glycolysis was investigated by examining glucose uptake consumption, lactate production, activities expressions glycolysis enzymes (PFK-L, HK2...
Colorectal cancer (CRC) remains the third most common tumor worldwide. Ulcerative colitis (UC) could cause chronic inflammation and ulcers in colon rectum. UC is a risk factor for high incidence of CRC, UC-associated CRC (UC-CRC) still increasing. Chinese medicine prescription, Xian-Lian-Jie-Du decoction (XLJDD), has been proven its efficacy some UC-CRC patients. However, mechanism XLJDD treating unknown. This study aimed to investigate UC-CRC.We constructed an AOM/DSS mouse model that...
Scutellaria barbata D. Don (S. barbata) is one of the most frequently used anticancer herb medicine in China. Mechanistic understanding biological activities S. hindered by limited knowledge regarding its components and metabolic profile. In this study, ultra-high-performance liquid chromatography coupled with high resolution mass spectrometry (quadrupole time-of-flight spectrometry) was to identify chemical constituents their profiles rats. By applying cleavage rules comparison reference...