A5101717366- Obsessive-Compulsive Spectrum Disorders
- Biodiesel Production and Applications
- Nanoplatforms for cancer theranostics
- Catalytic Processes in Materials Science
- Tryptophan and brain disorders
- Acute Ischemic Stroke Management
- Dermatology and Skin Diseases
- Biological and pharmacological studies of plants
- Axon Guidance and Neuronal Signaling
- Railway Engineering and Dynamics
- Electrical Contact Performance and Analysis
- Cancer, Hypoxia, and Metabolism
- Catalysis for Biomass Conversion
- Advanced Combustion Engine Technologies
- Ovarian function and disorders
- Methemoglobinemia and Tumor Lysis Syndrome
- Heme Oxygenase-1 and Carbon Monoxide
- Electric and Hybrid Vehicle Technologies
- Genomics, phytochemicals, and oxidative stress
- Brake Systems and Friction Analysis
- Viral-associated cancers and disorders
- Hepatitis C virus research
- Reproductive Health and Contraception
- Acne and Rosacea Treatments and Effects
- Ferroptosis and cancer prognosis
Wuhan University of Technology
2013-2024
Nanjing University of Chinese Medicine
2017-2022
Jinan University
2022
Integrated Chinese Medicine (China)
2022
Bethune International Peace Hospital
2020
Sichuan University
2015-2020
West China Second University Hospital of Sichuan University
2015
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory arthropathy associated with articular damage and attendant comorbidities. Even although RA treatment has advanced remarkably over the last decade, significant proportion of patients still do not achieve sustained remission. The cause yet known despite many potential mechanisms proposed. It been confirmed that dysregulated immune system persistent inflammation. Therefore, management inflammation always target therapy. Sinomenine...
In situ oxygen generation is the most common strategy to boost reactive species (ROS) for enhancing efficacy of phototherapy in cancer, including photodynamic therapy (PDT) and photothermal (PTT). However, hyperoxidation or hyperthermia often triggers stress-defense pathways promotes tumor cell survival, thus severely limiting therapeutic efficacy. To overcome hypoxia thermal resistance existing phototherapy, we constructed a self-synergistic nanoplatform tumors by incorporating brusatol,...
Adult hippocampal neurogenesis (AHN) is acknowledged to play a critical role in depression. Emerging evidence suggests that the Wnt/β-catenin pathway can modulate neurogenesis. Crocin, natural carotenoid, possesses antidepressant property. Yet, how it affects and exerts response remains unknown. To explore of AHN action crocin. Depressive-related behaviors, including sucrose preference test (SPT), tail suspension (TST), forced swimming (FST), sexual behaviors were performed following crocin...
Triptolide (TP), an active constituent of Tripterygium wilfordii, possesses numerous pharmacological activities. However, its effects on cytochrome P450 enzymes (CYP450s) in rats remain unexplored. In this study, the triptolide six main CYP450 isoforms (1A2, 2C9, 2C19, 2D6, 2E1, and 3A) were investigated both vivo vitro. We monitored body weight, survival proportions, liver index, changes pathology, biochemical index upon TP administration, vivo. Using a cocktail probe isoform-specific...
Abstract Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Recent epidemiological studies suggest that echinacoside (ECH), a phenylethanoid glycoside found in Cistanche deserticola , has protective effect against development PD. However, detailed mechanisms how ECH suppresses neuronal death have not been fully elucidated. In this study, we confirmed protects nigrostriatal neurons 6‐hydroxydopamine (6‐OHDA)‐induced endoplasmic reticulum stress (ERS) vivo and vitro...
Baicalin isolated from Scutellaria baicalensis possesses antidepressant abilities through its relation to hippocampal neurogenesis. Current research has found that baicalin can promote the proliferation of granule cells, however, detailed mechanism on survival and maturation cells yet be sufficiently explored. The purpose this study was evaluate whether could facilitate explore potential mechanism. chronic corticosterone (CORT)-induced mouse model depression used assess antidepressant-like...
The aim is to study the effects of gastrodin (GA) on striatal inflammation and oxidative stress in rats with Tourette syndrome (TS). rat model TS was induced by 3,3'-iminodipropionitrile. Behavioral tests were carried out stereotype experiment. concentrations amino acid transmitters glutamic (Glu) γ-aminobutyric (GABA) striatum determined high-performance liquid chromatography. Superoxide dismutase (SOD) malondialdehyde (MDA) serum detected commercial kits. Cytokines enzyme-linked...
Abstract Objective Tourette syndrome (TS) is a chronic neuropsychiatric disorder. Its clinical manifestations are involuntary and recurrent muscle twitch, resulting in motor twitch occurrence twitch. Traditional Chinese medicine has obvious advantages treating TS. The aim of this study was to investigate the effects mechanism gastrodin on 1‐(2,5‐dimethoxy‐4‐iodophenyl)‐2‐aminopropane (DOI)‐induced TS rats. Methods model induced by DOI. Behaviors rats were detected. striatum, serum...
A direct injection compression ignition engine fueled by diesel blended with 10% or 30% mass proportion of 2-methylfuran was experimentally studied. The in-cylinder combustion pressure, regulated emissions and particulate matter at different pilot timings masses were investigated under the exhaust gas re-circulation mode. It found blending methylfuran increased peak pressure retarded phase timings. addition heat release rate gradually along advancement timing. NOx, HC, CO timing when fixed...
Abstract Background Reactivation of hepatitis B virus is a common complication that occurs in patients with (HBV) infection who have received cytotoxic chemotherapy or immunosuppressive therapy. This clinical phenomenon not only overt HBV but also resolved infection. Previous research has confirmed epirubicin and dexamethasone can stimulate replication expression directly rather than indirectly through immunosuppression. Mitomycin 5-fluorouracil are currently used as drugs for cancer...
Objective. Tourette syndrome (TS) is a chronic neuropsychiatric disorder characterized by abnormal movements, phonations, and tics, but an accurate TS diagnosis remains challenging indeed depends on its description of clinical symptoms. Our study was conducted to discover verify some metabolite biomarkers based nontargeted targeted metabolomics. Methods. We untargeted ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) for preliminary...
In this study, the influences of injection timing and exhaust gas re-circulation on combustion emissions characteristics biodiesel/2-methylfuran blends are investigated a modified water-cooled 4-cylinder four-stroke direct compression ignition engine. The experimental conditions are, respectively, to adjust ratio at 0.38 MPa break mean effective pressure with engine speed 1800 rpm constantly. With in advance, peak cylinder rose while maximum heat re-lease rate first decreased next slightly...
Guanxin V (GX), a traditional Chinese medicine formula, is safe and effective in the treatment of coronary artery disease. However, its protective effect on myocardial ischaemia reperfusion injury (MIRI) unclear.To investigate cardioprotective GX MIRI explore potential mechanism.Sprague-Dawley male rats were divided into Sham, + groups. (6 g/kg) was administered to via intragastric administration for seven days before (IR) surgery. The infarct size, histopathology, serum enzyme activities,...
Introduction . To date, identifying emergent large vessel occlusion (ELVO) patients in the prehospital stage is important but still challenging. In this present study, we aimed to design a modified acute stroke severity (mPASS) scale identify ELVO and compared PASS which has been published. Methods. We retrospectively evaluated consecutive cohort of ischemic (AIS) our unit who visited emergercy department. These underwent CT angiography (CTA), MR (MRA), or digital subtraction (DSA) at...
With full development of 350km/h high-speed rail network in China, further research the key technology 380km/h or higher super-speed system has become crucial. Applying simulation pantograph-catenary interaction based on infinite element method, this paper simulated dynamic performance for high-tension overhead contact at over 350km/h. The findings showed that wave propagation speed can still serve as a brief computing method running within range 350-400km/h. When reaches 80% higher,...
Currently, biodiesel has been received much attention from many researchers around the world due to its clean and renewable characteristics. In present study, combustion emissions characteristics have studied on a modified four-cylinder, 4-stroke, water-cooled, direct injection compression internal engine equipped with common rail fuel system fueled methanol-biodiesel blends as well pure biodiesel. The experiment was operated at constant speed of 1800 rpm timing 2.5-22.5 ? crank angle before...
Abstract Background Tourette syndrome (TS) is a chronic neuropsychiatric disorder, characterized by abnormal movements and phonations, tics, but accurate TS diagnosis remains challenging indeed depends on its description of clinical symptoms. Our study was to identify some metabolites biomarkers based non-targeted targeted metabolomics. Methods We conducted untargeted ultra-high-performance liquid chromatography -quadrupole time-off light mass spectrometry (UHPLC-Q-TOF/MS) for preliminary...