A5102750175- Acute Ischemic Stroke Management
- Cancer-related molecular mechanisms research
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Infant Nutrition and Health
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Breastfeeding Practices and Influences
- Neonatal Respiratory Health Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Genomics and Diagnostics
- Effects and risks of endocrine disrupting chemicals
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Peripheral Artery Disease Management
- Neurological Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Circular RNAs in diseases
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Gestational Diabetes Research and Management
- Infant Development and Preterm Care
- Genetic Associations and Epidemiology
- Calcium signaling and nucleotide metabolism
Huazhong University of Science and Technology
2022-2025
Huashan Hospital
2025
Fudan University
2025
Zhejiang University
2015-2025
Tongji Hospital
2025
State Key Laboratory of Chemical Engineering
2025
Hangzhou First People's Hospital
2015-2024
Westlake University
2024
Nanjing University of Chinese Medicine
2020-2023
Hebei North University
2023
Abstract Background Necrotizing enterocolitis (NEC) is a leading gastrointestinal condition in preterm infants, characterized by significant morbidity and mortality. Early recognition of risk factors crucial for its prevention prediction. This study focuses on identifying that contribute to the development NEC neonates. Methods A case-control looked back at 144 newborns hospitalized Wuhan hospital between January 2010 March 2023 was carried out. Over same period, another children without...
Adjuvants are essential components of vaccines that have been particularly effective at promoting protective humoral immunity to infectious diseases and preventing mortality morbidity. There many different types adjuvants with modes action. A better understanding their potential adjuvanticity could provide guidance for the development novel cancer immunotherapy. In this article, we review importance in vaccine development, mechanisms action adjuvant-induced autoimmunity discuss some...
The diagnosis for pseudoprogression (PsP) and true tumor progression (TTP) of GBM is a challenging task in clinical practices. purpose this study to identify potential genetic biomarkers associated with PsP TTP based on the records, longitudinal imaging features, genomics data. We are first introduce radiogenomics approach candidate genes GBM. Specifically, novel sparse regression model was developed construct relationship between gene expression features. features were extracted from tumors...
Background: Contrast media extravasation can mimic hemorrhage after endovascular thrombectomy (EVT). Dual energy CT (DECT) has the potential to distinguish from iodine contrast. Methods: We retrospectively examined clinical and radiological data 106 consecutive acute ischemic stroke patients who received EVT underwent DECT immediately 24 h EVT. Iodine overlay map, virtual non-contrast, mixed images are reconstructed. Results: With use of DECT, proportion all diagnosed with hemorrhagic...
Background and Purpose— We aim to investigate whether lower admission serum calcium levels are associated with hemorrhagic transformation (HT) after intravenous thrombolysis (IVT). Methods— A total of 362 patients treated IVT was divided into 4 quartiles based on (Q1[<2.16], Q2[2.16, 2.23], Q3[2.24, 2.31], Q4[>2.31] mmol/L). HT classified as infarction parenchymal hemorrhage. Logistic regression applied assess the association between incidence HT. Results— Compared Q4, more common in...
Human milk (HM) has been associated with a lower risk of necrotizing enterocolitis (NEC). However, the association precise HM proportion outcome NEC remains unclear. A total 77 cases and 154 matched controls were included in this study. The samples divided into three groups based on enteral intake before onset: ≥70% (HHM), <70% (LHM), 0% (NHM). study cohort did not show significant between different proportions risk. adjusted odds ratio (OR) for highest versus lowest was 0.599. In...
Most previous studies have used single-phase computed tomographic angiography to detect the spot sign, a marker for hematoma expansion (HE) in spontaneous intracerebral hemorrhage. We investigated whether defining sign based on timing perfusion tomography (CTP) would improve its specificity predicting HE.We prospectively enrolled supratentorial hemorrhage patients who underwent CTP within 6 hours of onset. Logistic regression was performed assess risk factors HE and poor outcome. Predictive...
Background: Intracranial atherosclerotic stenosis (ICAS) is a common cause of first and recurrent ischemic stroke worldwide. Circular RNAs (circRNA)s have been recently suggested as candidate biomarkers in diagnosing prognosis stroke. A few circRNAs even serve therapeutic targets that improves neurological function after However, the roles ICAS caused (ICAS-stroke) not fully understood. Therefore, this study, we attempted to find some clues by investigating different expression profiles...
Aims: Although RNA-sequencing has been widely used to identify the differentially expressed genes (DEGs) as biomarkers guide therapeutic treatment, it is necessary investigate concordance of DEGs identified by microarray and for clinical prognosis. Material & methods: By using The Cancer Genome Atlas data sets, we thoroughly investigated from their molecular functions. Results: both technologies averaged ˜98.6% overlap. cancer-related gene sets were significantly enriched with consistent...
To investigate the potential of composite inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), in predicting outcomes patients with posterior circulation large vessel occlusion who underwent mechanical thrombectomy (MT).
The absence of the susceptibility vessel sign (negative SVS) on gradient-recalled echo or susceptibility-weighted imaging (SWI) in thrombolytic therapy has not been well studied. Since positive and negative SVS may have different components, we aimed to investigate difference risk factors for clinical outcome between patients with SVS.We retrospectively examined data from 85 consecutive acute ischemic stroke middle cerebral artery occlusion who underwent SWI before intravenous thrombolysis...
Biliary innervation is considered important in regulating the function of bile ducts, whereas role hepatobiliary system patients with biliary atresia (BA) remains unknown. This current study aims to investigate remnants and analyze relationship between prognosis BA after surgery.
We aim to investigate whether the phenomenon of "sudden drop" in blood pressure (BP) within first 2 hours is associated with vessel recanalization. retrospectively examined clinical and imaging data from a consecutive series patients stroke large occlusion treated intravenous thrombolysis (IVT). BP was monitored every 15 minutes during hours, then 30 for 6 hour 16 hours. observed systolic (≥20 mm Hg) 82 (50.9%) recanalization 87 (54.0%) 24 after treatment. This independently (odds ratio...