Hongfei Sang
A5033454280- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Procedures and Complications
- Diagnosis and Treatment of Venous Diseases
- Retinal and Optic Conditions
- Antiplatelet Therapy and Cardiovascular Diseases
- Liver Disease and Transplantation
- Intracranial Aneurysms: Treatment and Complications
- Central Venous Catheters and Hemodialysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Vascular anomalies and interventions
- Apelin-related biomedical research
- Organ Transplantation Techniques and Outcomes
- Coronary Interventions and Diagnostics
- Intracerebral and Subarachnoid Hemorrhage Research
- Diabetic Foot Ulcer Assessment and Management
- Liver Disease Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Vascular Malformations Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
Hangzhou First People's Hospital
2019-2025
Westlake University
2024-2025
Army Medical University
2020-2024
Xinqiao Hospital
2020-2024
Zhejiang University
2019-2024
Second Affiliated Hospital of Soochow University
2012-2024
Capital Medical University
2007-2024
Beijing Anzhen Hospital
2024
Soochow University
2012-2024
Xiamen University
2024
<h3>Importance</h3> For patients with large vessel occlusion strokes, it is unknown whether endovascular treatment alone compared intravenous thrombolysis plus (standard treatment) can achieve similar functional outcomes. <h3>Objective</h3> To investigate thrombectomy noninferior to alteplase followed by for achieving independence at 90 days among stroke. <h3>Design, Setting, and Participants</h3> Multicenter, randomized, noninferiority trial conducted 33 stroke centers in China. Patients (n...
Tirofiban is a highly selective nonpeptide antagonist of glycoprotein IIb/IIIa receptor, which reversibly inhibits platelet aggregation. It remains uncertain whether intravenous tirofiban effective to improve functional outcomes for patients with large vessel occlusion ischemic stroke undergoing endovascular thrombectomy.To assess the efficacy and adverse events before thrombectomy acute secondary occlusion.This investigator-initiated, randomized, double-blind, placebo-controlled trial was...
To investigate the efficacy and safety of IV infusion tirofiban before endovascular thrombectomy for patients with large vessel occlusion due to intracranial atherosclerotic disease. The secondary objective was identify potential mediators clinical effect tirofiban.
This study aimed to analyze the impact of baseline posterior circulation Acute Stroke Prognosis Early Computed Tomography Score (pc-ASPECTS) on efficacy and safety endovascular therapy (EVT) for patients with acute basilar artery occlusion. The BASILAR was a nationwide prospective registry consecutive symptomatic radiologically confirmed occlusion within 24 hours symptom onset. We estimated effect standard medical alone (SMT group) versus SMT plus EVT (EVT documented pc-ASPECTS noncontrast...
Remote ischemic conditioning (RIC) is a low-cost, accessible, and noninvasive neuroprotective treatment strategy, but its efficacy safety in acute stroke are controversial. With the publication of several randomized controlled trials (RCTs) recent results RESIST trial, it may be possible to identify patient population that (or not) benefit from RIC. This systematic review meta-analysis aims evaluate effectiveness RIC patients with receiving different treatments by pooling data all studies date.
<h3>Importance</h3> Endovascular therapy (EVT) has been reported to be safe and effective in improving clinical outcomes among patients with acute basilar artery occlusion (ABAO). The benefits associated EVT remain uncertain for ABAO severe symptoms (ie, National Institutes of Health Stroke Scale [NIHSS] score ≥ 21). <h3>Objectives</h3> To assess the identify factors symptoms. <h3>Design, Setting, Participants</h3> This prospective, nationwide cohort study was conducted using data from...
Background Two recent trials demonstrated a benefit for endovascular therapy (EVT) in the treatment of basilar artery occlusion (BAO). In light expected increase use EVT BAO, we sought to understand technique preferences neurointerventionalists performing BAO. Methods We conducted an international online survey physician opinions on BAO between January and March 2022. The was distributed through stroke neurointerventional organizations. Survey questions examined selection patients procedure...
The effect of imaging selection paradigms on endovascular thrombectomy outcomes in patients with acute ischemic stroke large vessel occlusion remains uncertain. study aimed to assess the basic (noncontrast computed tomography or without tomographic angiography) versus advanced (magnetic resonance perfusion) clinical following early and extended windows using a pooled analysis patient-level data from 2 pivotal randomized trials done China.This post hoc used 1182 included multicenter,...
BACKGROUND: The present study aimed to evaluate the efficacy and safety of intravenous tirofiban versus alteplase before endovascular treatment (EVT) in acute ischemic stroke patients with intracranial large vessel occlusion. METHODS: This was a post hoc analysis using data from 2 multicenter, randomized trials: DEVT trial (Direct Endovascular Treatment for Large Vessel Occlusion Stroke) May 2018 2020 RESCUE BT (Intravenous Tirofiban Before Thrombectomy Acute Ischemic October 2021. Patients...
Introduction： The role of endovascular thrombectomy (EVT) for acute extra-large ischemic stroke patients with large vessel occlusion (LVO) is uncertain. We aimed to explore the clinical and safety outcomes medical management (MM) plus EVT (EVT group) versus MM alone (MM among LVO within 24 hours last known well. Methods： XL STROKE (endovascular stroke) an investigator-initiated, nationwide, prospective registry blinded end point assessment performed at approximately 60 sites in China, will...
In recent years, the incidence of Atherosclerosis (AS) has been increasing and gradually become a major disease threatening human health. this study, we analyzed effect dapagliflozin on AS preliminarily explore mechanism action. First, apolipoprotein E (ApoE) knockout C57Bl/6J mice were used to establish an model in vitro. An intervention group treated with normal saline, both administered by gavage, set up. The effects macrophage polarization, blood lipids, inflammation, oxidative stress,...
Objective: Subarachnoid hemorrhage results in significant long-lasting neurologic sequelae. Here, we investigated whether human albumin improves long-term outcomes experimental subarachnoid and neurovascular remodeling is involved the protection of albumin. Design: Laboratory investigation. Setting: Hospital research laboratory. Subjects: Male Sprague-Dawley rats. Interventions: Rats underwent by endovascular perforation. Albumin either 0.63 or 1.25 g/kg was injected IV immediately after...
Two early basilar artery occlusion (BAO) randomized controlled trials did not establish the superiority of endovascular thrombectomy (EVT) over medical management. While many providers continue to recommend EVT for acute BAO, perceptions equipoise in randomizing patients with BAO versus management may differ between clinician specialties.We conducted an international survey (January 18, 2022 March 31, 2022) regarding strategies prior announcement two indicating EVT, and compared responses...
Background Catheter-directed thrombolysis (CDT) for deep venous thrombosis (DVT) of the lower extremity has good effect, but whether iliac vein stent placement after thrombolytic therapy is still controversial. The goal this study was to evaluate efficacy in following CDT DVT. Methods This a single-center, prospective, randomized controlled clinical trial. After receiving CDT, major branch distal completely patent 155 patients with DVT, and 74 these residual stenosis >50% were randomly...
Abstract Bradykinin receptors play important roles in cerebral ischaemia–reperfusion (I/R) injury of non‐diabetics. Their functions diabetics, however, have not been studied. In this study, we hypothesized that bradykinin 1 receptor (B1R) and 2 (B2R) would be upregulated participate the regulation diabetic ischaemic stroke. To investigate this, first evaluated B1R B2R expression at different time points after I/R non‐diabetic rats (Sprague–Dawley) by using real‐time quantitative reverse...
Importance The association of endovascular therapy (EVT) with outcomes is unclear for patients very low Alberta Stroke Program Early Computed Tomography Score (ASPECTS) within 24 hours stroke onset. Objective To explore the EVT functional and safety among ASPECTS 0 to 2 scored noncontrast computed tomography. Design, Setting, Participants This cohort study used data from an ongoing, prospective, observational, nationwide registry including all treated at 38 centers in China occlusion...
Background Six randomized trials have not detected a difference between intravenous alteplase plus endovascular thrombectomy and alone in stroke. Tenecteplase, recombinant human tenecteplase tissue‐type plasminogen activator, is genetically modified variant of alteplase. It unclear whether the outcomes are different if replaced with tenecteplase. This trial aims to determine within 4.5 hours time last known well confers benefit patients acute ischemic stroke large‐vessel occlusion who...
Background: Tirofiban, a glycoprotein IIb/IIIa receptor inhibitor, has been shown to reduce the risk of thrombotic complications during percutaneous coronary intervention. However, it remains unknown whether tirofiban improves outcomes in large vessel occlusion stroke patients undergoing endovascular treatment. Objective: This trial aims assess additional intravenous therapy can improve clinical who undergo treatment within 24 h symptom onset. Methods and design: The Endovascular Treatment...